Biocompatibility and osteoconductivity of scaffold porous composite collagen–hydroxyapatite based coral for bone regeneration

Siswanto, Siswanto; Hikmawati, Dyah; Kulsum, Umi; Rudyardjo, Djony Izak; Apsari, Retna; Aminatun, Aminatun

doi:10.1515/chem-2020-0080

Cited by 32 publications

(19 citation statements)

References 12 publications

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“…The introduction of different amplifiers to calcium phosphate ceramic structures and improving building and processing methods are among the most important strategies for increasing the mechanical properties of apatite ceramics and maintaining their biocompatibility. Metal particles [11], biocompatible glasses [8,12], as well as neutral ceramic phases, such as alumina [13], zirconia [14], collagen [15,16], and titanic [17], are among the phases that are added to its structure to improve the mechanical properties of HAp. Additives such as bioglass (BG) are used as the second part of the cement composite to improve physical and mechanical properties, increase biological properties (such as the osteoinductive effect), and to reduce infectiousness [18].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Ebrahimi

Sipaut

2021

Nanomaterials

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Composite scaffolds of hydroxyapatite (HAp) nanoparticles and bioactive glass (BG) have been applied as appropriate materials for bone tissue engineering. In this study, hydroxyapatite/bioglass cement in different ratios was successfully fabricated. To prepare HAp and HAp/BG cement, synthesized HAp and HAp/BG powder were mixed in several ratios, using different concentrations of sodium hydrogen phosphate (SP) and water as the liquid phase. The liquid to powder ratio used was 0.4 mL/g. The results showed that setting time increased with BG content in the composite. The results also showed that with the addition of bioglass to the HAp structure, the density decreased and the porosity increased. It was also found that after immersion in simulated body fluid (SBF) solution, the compressive strength of the HAp and HAp/BG cements increased with BG concentration up to 30 wt.%. SEM results showed the formation of an apatite layer in all selected samples after immersion in SBF solution. At 30 wt.% BG, greater nucleation and growth of the apatite layer were observed, resulting in higher bioactivity than pure HAp and HAp/BG in other ratios.

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Section: Introductionmentioning

confidence: 99%

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Ebrahimi

Sipaut

2021

Nanomaterials

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“…The parameters of metallic materials have significant properties, which have been shown to have properties higher than ceramics, which gives it a priority to be used in the field of tissue engineering. The biocompatibility of the metallic is lower than ceramics, which leads to allergic reactions in the blood clots [39]. The metallic nanomaterials have unique properties such as anti-microbial activity, high ratio of surface area, and biological, mechanical and physical properties [40,41].…”

Section: The Composites Of Ha/col/natural Polymersmentioning

confidence: 99%

The Natural and Commercial Sources of Hydroxyapatite/Collagen Composites for Biomedical Applications: A Review Study

et al. 2022

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Bone is considered the core unit that forms the human body’s skeleton, consisting primarily of hydroxyapatite (HA) and collagen (Col). The composites of hydroxyapatite/collagen had been prepared through different fabricated techniques and were used in many bone defects as biomaterials for bone tissue engineering. The incorporation of HA and collagen is possible due to the biocompatibility of collagen and the high mechanical properties of the HA. HA/Col composites have been used in many medical and biological fields. Current study have been discussed the synthesis and characterization techniques of HA/Col composites; the study have been included to study the cytotoxicity and cell attachment of the composites, along with their applications, as well as barriers that still remain to their successful development for clinical application.

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“…Hydroxyapatite has high osteoconduction properties, 98 and it was a material that merged into bone without adverse reaction. Hydroxyapatite is the most stable calcium phosphate ceramic material regarding temperature, pH and composition of intravascular fluid.…”

Section: Introductionmentioning

confidence: 99%

“…112 (2) Biocompatibility of material is pivotal in the scaffold system as it will protect living tissues from harm and toxicity. 98 The materials used for scaffold development must be able to be incorporated well into the body without showing any harmful effects. (3) Proper mechanical strength of scaffold is a prerequisite to bear the cell ingrowth.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Halim¹,

Hussein²,

Kandar

2021

IJN

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Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.

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Biocompatibility and osteoconductivity of scaffold porous composite collagen–hydroxyapatite based coral for bone regeneration

Cited by 32 publications

References 12 publications

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

The Natural and Commercial Sources of Hydroxyapatite/Collagen Composites for Biomedical Applications: A Review Study

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

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