“…When performing the tests necessary to assess the interactions from the biomaterial–tissue interface, the objective and subjective factors that may influence the response of the tissue, but also those of the biomaterial, are considered in order to correctly interpret the results, depending on the material factors and specifically those related to the surface [ 3 , 5 , 6 ]. The important parameters for the direct tissue–biomaterial contact [ 7 , 8 ] are the biocompatibility of the material chosen for the implant, the macrostructure (shape), the microstructure (surface roughness, geometry of the elevations, and depressions in the implant), the surgical implant procedure, the direct tissue–implant contact after insertion (implantation), and the time and manner of loading the implant, which may result in movements of the implant relative to the adjacent tissue and the implant support.…”