Biocompatibility In Vitro Tests of Mineral Trioxide Aggregate and Regular and White Portland Cements

Ribeiro, Daniel Araki; Duarte, Marco Antônio Húngaro; Matsumoto, Mariza Akemi; Marques, Mariângela Esther Alencar; Salvadori, Daisy Maria Fávero

doi:10.1097/01.don.0000153842.06657.e2

Cited by 111 publications

(79 citation statements)

References 36 publications

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“…Portland cement has been proven to be biocompatible through previous studies that showed cements are not genotoxins [17][18][19][20]. The main component in cement, namely tricalcium silicate (C3S), has been shown to induce cell proliferation and HAP deposition on its surface [21].…”

Section: Introductionmentioning

confidence: 99%

Portland cement enriched with hydroxyapatite for endodontic applications

Avram¹,

Gorea²,

Balint³

et al. 2017

Studia UBB Chemia

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Endodontic cement based on calcium silicate has been the focus of many studies. However, the quality of resulted endodontic cement needs improvement. This paper focuses on endodontic cement obtained from Portland cement enriched with two types of hydroxyapatite, simple and doped with 5% Zn. Hydroxyapatites were synthesized using a wet precipitation method and investigated by X-ray diffraction, FTIR, TEM and AFM. From a structural point of view, both hydroxyapatites were obtained in a single crystalline phase, containing particles in the nanometric range, as judged by XRD, TEM and AFM. FTIR analysis presents O-H and P-O bands specific to those in pure hydroxyapatite, confirming a hydroxyapatite lattice in both materials. Several experimental compositions of commercial Portland cement mixed with hydroxyapatite were prepared. The influence of stoichiometric and Zn doped hydroxyapatite on the resulted endodontic cement was observed in the setting time. The setting time for both cements decreased exponentially at both temperatures (22 ⁰C and 37 ⁰C). The normal consistency water remains constant for all experimented slurries.

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Section: Introductionmentioning

confidence: 99%

Portland cement enriched with hydroxyapatite for endodontic applications

Avram¹,

Gorea²,

Balint³

et al. 2017

Studia UBB Chemia

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“…Portland cement (PC) has emerged as an alternative to MTA because of its relative lower cost, similar chemical composition and biocompatibility with MTA, and several studies have compared both materials (12)(13)(14)(15)(16). As PC may potentially be used as an endodontic material (11,17), it does not have sufficient radiopacity to be visualized radiographically, and therefore a radiopacifying agent must be added to it (11).…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of Portland cement combined with different radiopacifying agents

et al. 2014

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The aim of this study was to evaluate the response of rat subcutaneous tissue to Portland cement combined with two different radiopacifying agents, iodoform (CHI 3 ) and zirconium oxide (ZrO 2 ). These materials were placed in polyethylene tubes and implanted into the dorsal connective tissue of Wistar rats for 7 and 15 days. The specimens were then stained with hematoxylin and eosin, and inflammatory reaction parameters were evaluated by light microscopy. The intensity of the inflammatory response to the sealants was analyzed by two blind calibrated observers throughout the experimental period. Histological analysis showed that all the materials caused a moderated inflammatory reaction at 7 days, which then diminished with time. At 15 days, the inflammatory reaction was almost absent, and fibroblasts and collagen fibers were observed indicating normal tissue healing. The degrees of the inflammatory reaction on different days throughout the experimental period were compared using the non-parametric Kruskal-Wallis test. Statistical analysis demonstrated no significant differences amongst the groups, and Portland cement associated with radiopacifying agents gave satisfactory results. Therefore, Portland cement used in combination with radiopacifying agents can be considered a biocompatible material. Although our results are very encouraging, further studies are needed in order to establish safe clinical indications for Portland cement combined with radiopacifying agents. (J Oral Sci 56, 29-34, 2014)

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“…A range of calcium silicate based materials are currently being investigated for their potential use in dental and bone-contact applications [11][12][13][14] . Previous research 15 has demonstrated the in vitro bioactivity of the calcium sulphate hemihydrate-tricalcium silicate composite bone cement.…”

Section: Introductionmentioning

confidence: 99%

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Torkittikul¹,

Chaipanich²

2009

ScienceAsia

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Biomaterials containing calcium silicate have been widely used in dental and bone repaired applications. This study investigated mechanical and in vitro biological properties of ordinary and white Portland cement both of which are composed mainly of calcium silicates. The time of setting was determined using a Vicat needle. Compressive strength was measured at the age of 1, 3, and 7 days. The 1 day set Portland cement pastes were soaked in a simulated body fluid to investigate the ability of the material to form a bond with living bone tissue. X-ray diffraction traces of samples following immersion in simulated body fluid demonstrated that both cement pastes form a hydroxyapatite layer within 7 days but white Portland cement shows a noticeably higher amount of apatite crystal than that of ordinary Portland cement. Scanning electron micrographs reveal a clear presence of hydroxyapatite on the surface of white, but not in ordinary Portland cement. In addition, white Portland cement can achieve a compressive strength of 30 MPa within 24 h after curing in distilled water at human temperature.

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Biocompatibility In Vitro Tests of Mineral Trioxide Aggregate and Regular and White Portland Cements

Cited by 111 publications

References 36 publications

Portland cement enriched with hydroxyapatite for endodontic applications

Portland cement enriched with hydroxyapatite for endodontic applications

Biocompatibility of Portland cement combined with different radiopacifying agents

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