Biocompatibility of fluorinated polyimide

Abstract

Contact between blood and biomaterial triggers a complex series of events including protein adsorption, leukocyte adhesion and activation, and complement activation. In this article, a series of fluorinated polyimides cured at a different temperatures was prepared, and the biocompatibility of the membranes was evaluated using in vitro protein adsorption, neutrophil adhesion, and complement activation experiments under static conditions. We found that protein adsorption, neutrophil adhesion, and complement activation for the polyimides significantly depends on the curing temperature and decreases with an increase in the temperature and that the polyimide has a good biocompatibility compared with poly(styrene) and polydimethylsiloxane. We concluded that the rearrangement of molecules such as CF(3), sulfone, and ketone at the outermost surface occurs because of curing, which induces an increase in the hydrophobicity and that the cured polyimide suppresses protein adsorption, neutrophil adhesion, and complement activation because of its high hydrophobicity and low surface free energy.

Micro-field evoked potentials recorded from the porcine sub-dural cortical surface utilizing a microelectrode array

“…1. The results of this qualitative analysis, which demonstrated that the microelectrode and control surfaces were not toxic to the human and mammal cells (Black, 1999), along with the widely accepted use of polymides and gold in biomedical devices (Schneider and Steiglitz, 2004;Liu et al, 2003;Kanno et al, 2002;Klinge et al, 2001), suggest that the Kapton and gold microelectrode array is suitable for use with human patients.…”

Small-aperture corneal inlay for the correction of presbyopia: 3-year follow-up

“…12 A carbon pigment makes the inlay opaque. Sixteen hundred holes (25 mm diameter) arranged in a randomized pattern allow nutritional flow through the implant into the anterior stromal tissue to prevent corneal melting.…”

Interaction Study of 2,6‐Bis[4‐(4‐amino‐2‐trifluoromethyl phenoxy)benzoyl] Pyridine with Human Immunoglobulin by Optical Spectroscopy and Molecular Modeling

“…By Förster theory, 22 the efficiency of energy transfer (E) is related to the distance R (Å) between the donor and acceptor by 6 6…”

“…4,5 In recent publications, more studies have been focused on the study on biocompatibility of polyimide. 6,7 In this paper, we report the interaction between a kind of heteroaromatic diamine monomer (2,6-bis[4-(4-amino-2-trifluoromethyl phenoxy)benzoyl] pyridine (BAFP, the chemical structure shown in Figure 1 8 ) with human immunoglobulin (HIgG) under simulated physiological conditions by molecular modeling and different spectroscopic methods. The partial binding parameters of the reaction were calculated through SGI FUEL workstations.…”