Biocompatibility of New Calcium Aluminate Cement (EndoBinder)

Aguilar, Fabiano Gamero; Garcia, L; Pires‐de‐Souza, Fernanda de Carvalho Panzeri

doi:10.1016/j.joen.2011.11.002

Cited by 62 publications

(73 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, various in vivo studies that assessed the biocompatibility of this cement (21,22) demonstrated that after 30 days, the material allowed adequate tissue repair, indicating that the alkaline pH produced by calcium ion release was maintained (22,23). It is believed that this ability to maintain the alkaline pH of the medium is the main responsible for the excellent biological performances of MTA and EndoBinder (21).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

View full text Add to dashboard Cite

This study aimed to evaluate the cytotoxicity of a calcium aluminate cement (EndoBinder) containing different radiopacifiers, Bi 2 O 3 , ZnO or ZrO 2 , compared with Mineral Trioxide Aggregate (MTA). According to ISO 10993-12:2012 (E) recommendations, 0.2 g of each cement were applied in transwell inserts and placed in 24-well culture plates containing 1 mL of culture medium (DMEM). After 24 h of incubation, the extracts (DMEM containing components released from the cements) were applied to immortalized odontoblast-like MDPC-23 cells. Cell viability (MTT test), alkaline phosphatase activity (ALP), total protein production and cell morphology (Scanning Electron Microscopy -SEM) were evaluated. The volume of 50 µL of extract was used to determine the chemical elements released by the cements using Energy Dispersive Spectroscopy (EDS). The following groups were established (n=6): NC -negative control (without treatment); EB -EndoBinder without radiopacifier; EBBO -EndoBinder+Bi 2 O 3 ; EBZnO -EndoBinder+ZnO; EBZrOEndoBinder+ZrO 2 and WMTA -White MTA. Data were subjected to statistical analysis (Kruskal-Wallis test, level of significance=5%). Cells exposed to the different versions of EndoBinder presented small reduction in viability, total protein production and ALP activity, with values similar to the NC and WMTA groups (p>0.05). Different elements (C, O, Na, Al, P, Si, Cl, Bi, K) released by the cements were detected in the extracts. However, the cells had no significant changes in their morphology. EndoBinder and MTA did not affect negatively the metabolism of the odontoblastic-like cells, showing it to be cytocompatible, irrespective of the used radiopacifier.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

View full text Add to dashboard Cite

show abstract

“…These products have not been included here as the use of a bone graft material for pulp therapy is 'off-label' and further research is required. Also, EndoBinder® (Binderware, São Carlos, Brazil) is a calcium aluminate cement with no calcium silicates, and is a permanent restorative HDC but has not yet been commercialised (35). The GMDN currently has dental restorative materials divided into subcategories based upon their setting reactions.…”

Section: Hygroscopic Dental Cement Classificationsmentioning

confidence: 99%

Classification and Nomanclature of Commercial Hygroscopic Dental Cements

Ha¹,

Kahler²,

Walsh³

2017

Eur Endod J

View full text Add to dashboard Cite

Objective: Under the Global Medical Device Nomenclature (GMDN) system, the newly introduced term 'hygroscopic dental cement' (HDC) encompasses MTA as well as cements based on bioceramics, calcium silicate or calcium sulphate. Many HDCs have a long history of use in dentistry. There is a need for a consistent, logical and informed approach to the nomenclature of traditional and novel HDCs. Methods: Commercial manufacturers of HDC were contacted requesting information on the compositions of products. Manufacturers that were unknown to the authors, that were unable to be contacted, that wished to be excluded from this paper, or that did not send their information on compositions in due time were not included. Results:The compositions of commercial HDCs include various hybrids of calcium silicates, calcium aluminates, calcium phosphates, calcium sulphate as well as zinc sulphates. Furthermore, there are variations in the radiopacifier as well as additives that change the handling or setting processes. Conclusion:The inclusion of different additives to HDCs enables variation in handling properties such that they now exist as distinct putties and sealers as well as cements.

show abstract

“…It is composed of oxides of aluminium (Al 2 O 3 ), calcium, (CaO), silicon (SiO 2 ), magnesium(MgO) and iron (Fe 2 O 3 ) [27,28] . It also allows the control of impurities such as Fe 2 O 3 (which promotes tooth darkening) and is free of MgO and CaO which restricts the undesirable expansion of the material upon moisture contact [29,30] .…”

Section: Calcium Enriched Mixture (Cem)mentioning

confidence: 99%