Biocompatibility of root-end filling materials: recent update

Abstract

The purpose of a root-end filling is to establish a seal between the root canal space and the periradicular tissues. As root-end filling materials come into contact with periradicular tissues, knowledge of the tissue response is crucial. Almost every available dental restorative material has been suggested as the root-end material of choice at a certain point in the past. This literature review on root-end filling materials will evaluate and comparatively analyse the biocompatibility and tissue response to these products, with primary focus on newly introduced materials.

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

“…Endodontic therapy aims to eliminate endodontic infection through the removal of microorganisms from the root canal system by cleaning and shaping, 8 in addition to promoting the re-establishment of periapical tissues by using an inert and biocompatible material. 9 However, previous studies have already described that the chemical composition of endodontic materials can affect the inflammatory response and repair processes, 10 and also interfere with systemic health since these materials release toxic substances. 11,12 Although the relationship between AP and systemic disorders has already been documented, 13,14 the tissue response to biomaterials depends on the immune response, 15,16 so systemic disorders can alter immune function and affect the healing process.…”

Systemic bone marker expression induced by grey and white mineral trioxide aggregate in normal and diabetic conditions

“…Root-end filling and repair materials should be biocompatible with the periradicular tissues and have suitable chemical and physical properties to promote healing (Saxena et al 2013). MTA is calcium silicatebased cement, developed as a root-end filling material and used in various clinical procedures (Parirokh & Torabinejad 2010) owing to its excellent properties (Torabinejad et al 1995).…”

Tricalcium silicate cements: osteogenic and angiogenic responses of human bone marrow stem cells

“…It is therefore important that these dental materials are biocompatible, preferably promote wound healing and hard tissue formation, and are hydrophilic (as they are applied and function in a wet environment) . They should also demonstrate dimensional stability, and are known to have antibacterial effects because of their high pH .…”