Biocompatibility of silver nanoparticles and silver ions in primary human mesenchymal stem cells and osteoblasts

Pauksch, L.; Hartmann, Sonja; Rohnke, Marcus; Szalay, Gabor; Alt, Volker; Schnettler, Reinhard; Lips, Katrin Susanne

doi:10.1016/j.actbio.2013.09.037

Cited by 246 publications

(188 citation statements)

References 38 publications

Supporting

Mentioning

166

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the possibility of the biocompatibility of orthopedic implants being compromised by the cytotoxicity of AgNPs against osteoblasts and osteoclasts is a major concern. In a study conducted by Pauksch et al, 55 osteoblasts were found to have a higher susceptibility to toxicological effects of less than 5 nm sized AgNPs than osteoclasts. In this study, AgNPs at ~30 nm size released more Ag + then the larger AgNPs, alluding to a similar size selectivity as that of the RBC and AgNP interaction.…”

Section: Toxicitymentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

530

334

View full text Add to dashboard Cite

The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment.

show abstract

Section: Toxicitymentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

530

334

View full text Add to dashboard Cite

show abstract

“…Among these, silver nanoparticles (AgNPs) have become the focus of much research interest due to their unique optical, electrical and biological properties which offers a number of exciting potential applications in various fields including catalysis, electronics and biology (Prabhu and Poulose 2012). They possess an excellent biocompatibility and low toxicity (Pauksch et al 2014). Silver nanoparticles have been documented in the field of biomedical (Chaloupka et al 2010), drug delivery (Prow et al 2011), food industries (Chaudhry and Castle 2011), agriculture (Nair et al 2010), textile industries (Kelly and Johnston 2011), water treatment (Dankovich and Gray 2011), antioxidant (Niraimathi et al 2013), antimicrobial (Sankar et al 2013), anti-cancer (Boca et al 2011), cosmetics (Jain et al 2009), ointments (Murphy 2008) and larvicides (Roopan et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted green synthesis of silver nanoparticles from Fraxinus excelsior leaf extract and its antioxidant assay

et al. 2015

View full text Add to dashboard Cite

The biosynthesis of nanoparticles has been proposed as a cost effective and environmentally benevolent alternative to chemical and physical methods. In the present study, microwave assisted synthesis of silver nanoparticles (AgNPs) has been demonstrated using leaf extract of Fraxinus excelsior reducing aqueous AgNO 3 solution. The synthesized nanoparticles have been characterized on the basis of fourier transform infrared spectroscopy (FT-IR), UV-Vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy dispersive X-ray (EDX) analysis. The presence of a characteristic surface plasmon resonance (SPR) absorption band at 425 nm in UV-Vis reveals the reduction of silver metal ions into silver nanoparticles. FT-IR analysis was carried out to probe the possible functional group involved in the synthesis of AgNPs. Further leaf extracts and AgNPs were evaluated for antiradical scavenging activity by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay.

show abstract

“…10 Several reports have found that the potential toxic effect caused by NS occurred only at high concentrations, and incorporated NS into biomaterials probably reduce the toxicity of NS. [11][12][13] Consequently, it is available to incorporate an optimized concentration of NS into a material to prepare an antibacterial wound dressing without cytotoxicity.…”

mentioning

confidence: 99%

“…Therefore, these results indicated that the cytotoxicity of NS occurred at high concentration as previously described. 11,12 Because of effective antibacterial activity without observed cytotoxicity, PCL/NS1.0 was chosen as the optimized film for the next experiments. The abovementioned results also demonstrated that an optimized concentration of NS was successfully found as expected.…”

mentioning

confidence: 99%

Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo

Liu¹,

Luo²,

Wang³

et al. 2017

IJN

View full text Add to dashboard Cite

Bacterial infection is a major hurdle to wound healing, and the overuse of antibiotics have led to global issue, such as emergence of multidrug-resistant bacteria, even “super bacteria”. On the contrary, nanosilver (NS) can kill bacteria without causing resistant bacterial strains. In this study, NS was simply generated in situ on the polycaprolactone (PCL) nanofibrous mesh using an environmentally benign and mussel-inspired dopamine (DA). Scanning electron microscopy showed that NS uniformly formed on the nanofibers of PCL mesh. Fourier transform infrared spectroscopy revealed the step-by-step preparation of pristine PCL mesh, including DA coating and NS formation, which were further verified by water contact angle changing from hydrophobic to hydrophilic. To optimize the NS dose, the antibacterial activity of PCL/NS against Staphylococcus aureus , Escherichia coli and Acinetobacter baumannii was detected by bacterial suspension assay, and the cytotoxicity of NS was evaluated using cellular morphology observation and Cell Counting Kit-8 (CCK8) assay. Then, inductively coupled plasma atomic emission spectrometry exhibited that the optimized PCL/NS had a safe and sustained silver release. Moreover, PCL/NS could effectively inhibit bacterial infection in an infectious murine full-thickness skin wound model. As demonstrated by the enhanced level of proliferating cell nuclear antigen (PCNA) in keratinocytes and longer length of neo-formed epidermis, PCL/NS accelerated wound healing by promoting re-epithelialization via enhancing keratinocyte proliferation in infectious wounds.

show abstract

Biocompatibility of silver nanoparticles and silver ions in primary human mesenchymal stem cells and osteoblasts

Cited by 246 publications

References 38 publications

Antibacterial properties and toxicity from metallic nanomaterials

Antibacterial properties and toxicity from metallic nanomaterials

Microwave-assisted green synthesis of silver nanoparticles from Fraxinus excelsior leaf extract and its antioxidant assay

Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo

Contact Info

Product

Resources

About