Biocompatible and antibacterial soy protein isolate/quaternized chitosan composite sponges for acute upper gastrointestinal hemostasis

Wang, Zijian; Ke, Meifang; Liu, He; Dong, Qi; Liang, Xiao; Rao, Jun; Ai, Junjie; Tian, Chuan; Han, Xinwei

doi:10.1093/rb/rbab034

Cited by 16 publications

(2 citation statements)

References 39 publications

(37 reference statements)

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“…0.2 g CB/Lid-n samples and 10 mL normal saline were added into 15 mL tubes, followed by adding 0.2 mL diluted blood. According to our previous work, a positive control group and a negative control group were also set [ 30 ]. All the samples were incubated at 37 ℃ for 60 min, and then centrifuged at 1000 rpm for 10 min.…”

Section: Methodsmentioning

confidence: 99%

One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization

et al. 2022

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Background Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer. The pain caused by TAE is a stark complication, which remains to be prevented by biomedical engineering methods. Methods Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique. The products were coded as CB/Lid-n (n = 0, 5, 10, corresponding to the relative content of Lid). The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated. The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR. The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model. A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model. Results Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid. CB/Lid-n exhibited desirable drug-loading ratio, drug-embedding ratio, and sustained drug-release capability. CB/Lid-n had mild toxicity towards L929 cells, while triggered no obvious hemolysis. Furthermore, CB/Lid-n could improve the carrageenan-induced inflammation response micro-environment in vivo and in vitro. We found that CB/Lid-10 could selectively kill tumor by blocking blood supply, inhibiting cell proliferation, and promoting cell apoptosis. CB/Lid-10 could also release Lid to relieve post-operative pain, mainly by remodeling the harsh inflammation micro-environment (IME). Conclusions In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.

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Section: Methodsmentioning

confidence: 99%

One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization

et al. 2022

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“…Some natural polymers are with good biocompatibility, biodegradability, weak immunogenic effects and cost-effectiveness [ 173 , 174 ]. Typical examples are silk fibroin [ 175 , 176 ], chitosan [ 177–179 ], hyaluronic acid [ 180 , 181 ] and alginate [ 182 ]. Silk fibers were originally used as suture biomaterials owing to their unique mechanical properties [ 183 ].…”

Section: The Different Sources Of Biomaterials For Tissue Regenerationmentioning

confidence: 99%

Recent advances in regenerative biomaterials

Cao

Ding

2022

Regenerative Biomaterials

115

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Nowadays, biomaterials have evolved from the inert supports or functional substitutes, to the bioactive materials able to trigger or promote the regenerative potential of tissues. The interdisciplinary progress has broadened the definition of “biomaterials”, and a typical new insight is the concept of tissue induction biomaterials. The term “regenerative biomaterials” and thus the contents of the present paper are relevant to yet beyond tissue induction biomaterials. This review summarizes the recent progress of medical materials including metals, ceramics, hydrogels, other polymers, and bio-derived materials. As the application aspects are concerned, this paper introduces regenerative biomaterials for bone and cartilage regeneration, cardiovascular repair, three dimensional bioprinting, wound healing, and medical cosmetology. Cell-biomaterial interactions are highlighted. Since the global pandemic of COVID-19, the review particularly mentions biomaterials for public health emergency. In the last section, perspectives are suggested: (1) Creation of new materials is the source of innovation; (2) Modification of existing materials is an effective strategy for performance improvement; (3) Biomaterial degradation and tissue regeneration are required to be harmonious with each other; (4) Host responses can significantly influence the clinical outcomes; (5) The long-term outcomes should be paid more attention to; (6) The non-invasive approaches for monitoring in vivo dynamic evolution are required to be developed; (7) Public health emergencies call for more research & development of biomaterials; (8) Clinical translation needs to be pushed forward in a full-chain way. In the future, more new insights are expected to be shed into the brilliant field — regenerative biomaterials.

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Dihydromyricetin-Incorporated Multilayer Nanofibers Accelerate Chronic Wound Healing by Remodeling the Harsh Wound Microenvironment

et al. 2022

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Biocompatible and antibacterial soy protein isolate/quaternized chitosan composite sponges for acute upper gastrointestinal hemostasis

Cited by 16 publications

References 39 publications

One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization

One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization

Recent advances in regenerative biomaterials

Dihydromyricetin-Incorporated Multilayer Nanofibers Accelerate Chronic Wound Healing by Remodeling the Harsh Wound Microenvironment

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