2017
DOI: 10.1371/journal.pone.0174687
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Biocompatible astaxanthin as a novel marine-oriented agent for dual chemo-photothermal therapy

Abstract: The photothermal effect of a marine-oriented xanthophyll carotenoid, astaxanthin (AXT), was characterized based on its potential absorption of visible laser light and conversion of optical light energy into heat for thermal treatment. As an antioxidant and anticancer agent, AXT extracted from marine material can be utilized for photothermal therapy due to its strong light absorption. The current study investigated the feasibility of the marine-based material AXT to increase the therapeutic efficacy of chemo-ph… Show more

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Cited by 24 publications
(15 citation statements)
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“…345 Research related to the diverse bioactivity of astaxanthin continues to appear in the literature and in the latest study, astaxanthin has been reported to have promising chemo-photothermal toxicity towards drug resistant tumours. 346…”
Section: Green Algaementioning
confidence: 99%
“…345 Research related to the diverse bioactivity of astaxanthin continues to appear in the literature and in the latest study, astaxanthin has been reported to have promising chemo-photothermal toxicity towards drug resistant tumours. 346…”
Section: Green Algaementioning
confidence: 99%
“…PAT typically uses either a single or an array ultrasound transducer to detect the PA signal and target both microscopic and macroscopic imaging, whereas PAM and PAE usually use a focused ultrasound transducer to acquire PA signals and generally image tissue with micron-scale spatial resolution and millimeter-scale depth. The application of PA imaging has expanded from the cellular to the tissue level, such as imaging of the brain, blood vessels in the brain, liver, breast, joints, and blood vessels in the eye [17,29-31]. In ophthalmology, several groups have investigated PA ocular imaging platforms to evaluate ocular tissues with a high depth of penetration [18,22,32-35].…”
Section: Physical Principle Of Photoacoustic Imagingmentioning
confidence: 99%
“… 18 PI was used to investigate changes in cell nuclear morphology, apoptosis, and necrosis. 19 Cell apoptosis assay was observed using PI/Annexin V double staining and flow cytometry. HCT-116 cells were seeded into 6-well plates at a density of 2×10 5 /well overnight.…”
Section: Methodsmentioning
confidence: 99%