Biocompatible benzocyclobutene (BCB)-based neural implants with micro-fluidic channel

Lee, Keekeun; He, Jiping; Clement, Ryan S.; Massia, Stephen P.; Kim, Bruce

doi:10.1016/j.bios.2004.02.005

Cited by 76 publications

(46 citation statements)

References 7 publications

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“…Perhaps most importantly, the soft modulus after implantation (ca. 10 MPa) is signifi cantly lower than that of silicon or tungsten ( ∼ 100 GPa) 54 or even that of other fl exible polymers used in neural interfacing, such as polyimide, 40 poly(benzocyclobutene), 47 or poly( p -xylylenes) (parylene) ( ∼ 2-3 GPa). 42 , 55 Furthermore, electrodes based on such fl exible polymers require temporary stiffening to allow for implantation, something that is not required by an appropriate mechanically adaptable material ( vide infra ).…”

Section: Comparison Of Mechanically Adaptive Nanocomposites To Other mentioning

confidence: 99%

Mechanically adaptive nanocomposites for neural interfacing

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Section: Comparison Of Mechanically Adaptive Nanocomposites To Other mentioning

confidence: 99%

Mechanically adaptive nanocomposites for neural interfacing

et al. 2012

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“…The mechanical mismatch between these stiff substrates and soft tissue [ 17 ] aggravates micromotion at the tissue-electrode contact sites, which will induce infl ammation inside the tissue. [ 18 ] To solve this problem, polymer materials, such as SU-8, [ 19 ] parylene, [ 20 ] polyimide, [ 21 ] liquid crystal polymer, [ 22 ] silk, [ 23 ] and benzocyclobutene (BCB), [ 24 ] are employed to fabricate fl exible neural interfaces. As these materials can change shape when the neural tissue deforms, fl exible neural interfaces made of these materials can avoid a gradual shift in recording location and a decrease in the signal to noise ratio.…”

Section: Doi: 101002/adma201503423mentioning

confidence: 99%

Progress of Flexible Electronics in Neural Interfacing – A Self‐Adaptive Non‐Invasive Neural Ribbon Electrode for Small Nerves Recording

et al. 2015

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“…Benzocyclobutene can be used as an alternative to polyimide in the fabrication of neural interfaces. For example, Lee, He & Wang (2004) reported the fabrication of benzocyclobutene coated neural implants with embedded microfluidic channels (Lee, He & Wang (2004); Lee, Clement, Massia & Kim (2004)). An important development direction in Europe is the development of flexible electrodes for cortical (Myllymaa et al (2009);Rubehn et al (2009)) and peripheral nerve recording (Navarro et al (2001); Stieglitz & Meyer (1999)).…”

Section: Flexible Substratesmentioning

confidence: 99%

New Trends and Challenges in the Development of Microfabricated Probes for Recording and Stimulating of Excitable Cells

Braeken¹,

Prodanov²

2010

New Developments in Biomedical Engineering

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types of neural prostheses are unclear. Notable exceptions for this are the auditory cochlear prostheses, which exploit the sonotopic organization of the cochlea, the cardiac pacemakers, the phrenic stimulator and the foot drop stimulator. Current DBS systems for Parkinson's disease rely on the high frequency stimulation, which can result in blocking of certain mid-brain pathways. The encoding of the kinematic information in these structures is still unknown. Dissociated cell cultures lose their anatomical connectivity and structure when seeded on substrates in vitro. The 'new' situation that exists on these surfaces is interesting in terms of communication between individual cells and their function in advanced networks. However, the translation of these processes to the in vivo situation is not always straightforward and challenging. On the level of the overall device several types of issues can be grouped in the categories of configuration and operation. Issues related to the configuration can be related to the assembly, the size and topology of the device, the encapsulation and the packaging of the device. Devices have to be packaged in a way that prevents leakage of the environment, which contains high salt and protein concentrations, to the chip. These packages have to be leakage-proof on the one hand and non-toxic for the cell culture or tissue on the other hand. Issues related to the operation of the device can be grouped under the power, safety and communication of the device. The operation has to be compatible with cell cultures or in vivo environments, which in this case has to be in agreement with certain regulations. One other important aspect of the safety of operation are the interactions with other equipment, for example MRI.

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Biocompatible benzocyclobutene (BCB)-based neural implants with micro-fluidic channel

Cited by 76 publications

References 7 publications

Mechanically adaptive nanocomposites for neural interfacing

Mechanically adaptive nanocomposites for neural interfacing

Progress of Flexible Electronics in Neural Interfacing – A Self‐Adaptive Non‐Invasive Neural Ribbon Electrode for Small Nerves Recording

New Trends and Challenges in the Development of Microfabricated Probes for Recording and Stimulating of Excitable Cells

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