Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications

Hussein, Jihan; El-Banna, Mona; Razik, Tay Abdel; El‐Naggar, Mehrez E.

doi:10.1016/j.ijbiomac.2017.09.056

Cited by 73 publications

(33 citation statements)

References 28 publications

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“…Leukotriene-5, thromboxane-3, and prostaglandin-3 are derived from essential fatty acids, and are known to be therapeutically valuable in inflammation and mental health conditions (de Batlle et al, 2012;Huan et al, 2004;Kiecolt-Glaser et al, 2011;Peet et al, 2001;Perica & Delas, 2011). Hussein et al (2018) reported that ILs are essential cytokines involved in several immunological processes. Supplementation with omega-3 fatty acids has been shown to reduce levels of inflammatory markers and lipid peroxidation in chronic cardiomyopathy patients (Silva et al, 2017) Scale bar is 100 µm supplementation on inflammatory markers in chronic kidney disease.…”

Section: Discussionmentioning

confidence: 99%

“…Reactive oxygen species (ROS) and proinflammatory cytokines are produced in inflammatory and neurodegenerative states (Block & Hong, 2005;Min et al, 2004;Qin et al, 2004). Hussein, El-Banna, Razik, and El-Naggar (2018) reported that interleukins (IL) are essential cytokines involved in several immunological processes. The microglia release pro-nerve growth factor (pro-NGF), which leads to cell death (Yune et al, 2007).…”

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confidence: 99%

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Neuroprotective effect of omega‐3 fatty acids on spinal cord injury induced rats

Chen

Sun

et al. 2019

Brain and Behavior

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Introduction In this study, the effects of omega‐3 fatty acids were examined in a rat model of spinal cord injury. Methods The rats were classified into sham, control, spinal cord injury plus 50 mg/kg Omega‐3 fatty acids and spinal cord injury plus 100 mg/kg Omega‐3 fatty acids. The levels of oxidative, apoptotic, and inflammatory markers were examined in each of these groups. Results Altered lipid peroxidation, reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (Gpx), and catalase were normalized. Omega‐3 fatty acid supplementation decreased tumor necrosis factor‐alpha (TNF‐α) and interleukin‐6 (IL‐6) levels by >50%. TNF‐α and IL‐6 mRNA expression were reduced. Caspase‐3, p53, bax, and pro‐NGF mRNA expression levels were increased by 1.3‐, 1.4‐, 1.2‐, and 0.9‐fold, respectively, whereas bcl‐2 mRNA expression was decreased by 0.77‐fold in control rats. Omega‐3 fatty acid supplementation decreased p53, caspase‐3, bax, and pro‐NGF mRNA expression by >40%, while the level of bcl‐2 mRNA expression was increased by 286.9%. Omega‐3 fatty acid supplementation decreased caspase‐3 and p53 protein expression by >30%. Conclusion Taken together, our results suggested that omega‐3 fatty acid supplementation reduced oxidative stress, apoptosis, and the levels of inflammatory markers in ischemia‐reperfusion‐induced rats.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Neuroprotective effect of omega‐3 fatty acids on spinal cord injury induced rats

Chen

Sun

et al. 2019

Brain and Behavior

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“…Zinc oxide nanoparticles (ZnONPs) belongs to the class of metal oxides, which is characterized by photocatalytic and photo-oxidizing capacity against chemical and biological species [10]. Within the large family of metal oxide nanoparticles, zinc oxide nanoparticles have been used in various cutting-edge applications like electronics, communication, sensor, cosmetics, environmental protection, biology and medicinal industry [11][12][13][14][15]. Moreover, zinc oxide nanoparticles have a tremendous potential in biological applications like biological sensing, biological labelling, gene delivery, drug delivery and nanomedicines.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of Zinc oxide nanoparticles (ZnO NPs) and their biological activity

2018

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Zinc oxide (ZnO) has broad applications in various areas. Green synthesis is an alternative to conventional physical and chemical methods. Green synthesis of nanoparticles is gaining importance due to its cost-effectiveness, reduction of toxic chemicals and extensive antimicrobial activity. Herein, we have discovered synthesis of zinc oxide nanoparticles (ZnONPs) using agro waste materials like sheep and goat faecal matter as a reducing agent. Synthesized ZnONPs were evaluated for their purity, particle size, morphological structure, using UV-visible spectroscopy, Fourier transforms infrared spectroscopy, X-ray diffraction and scanning electron microscope analysis. However, nanoparticles gain low crystallite size, they seemed to be uneven structures like spongy like and flower shaped particles. Obtained nanoparticles exhibit good antimicrobial activity and minimum inhibitory concentration against Salmonella typhimurium and Bacillus subtilis. Agro-waste based green synthesized ZnONPs possess small sized particles, enhances the good antimicrobial effect. This research leads to develop a new way of cost-effective synthesis and reducing usage of chemicals in further studies.

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“…In the current study, ZnO-NPs were produced by green biosynthesis, and the chemical stabilization of spherical ZnO-NPs by the acacia template as a natural, biodegradable polymer is proposed for the action of nucleation and crystal growth of ZnO-NP crystallites [ 13 ]. This process is preceded by an induction period of Zn cations and acacia precursor polymer in the solid state.…”

Section: Discussionmentioning

confidence: 99%

“…The particle size and size distribution of the obtained ZnO-NPs were investigated by using a high-resolution transmission electron microscope (HRTEM; JEOL-JEM-1200) [ 13 ]. The HRTEM samples were prepared by dropping a dilute suspension of ZnO-NPs onto copper-coated grids.…”

Section: Methodsmentioning

confidence: 99%

Impact of dietary zinc oxide nanoparticles on selected serum biomarkers, lipid peroxidation and tissue gene expression of antioxidant enzymes and cytokines in Japanese quail

et al. 2020

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Background The use of zinc oxide in the form of nanoparticles (ZnO-NPs) is of great benefit due to its potent effectiveness and higher bioavailability compared to zinc oxide. This study aimed to investigate the impact of dietary inclusion of different doses of ZnO-NPs on selected serum biomarkers, lipid peroxidation and tissue gene expression of antioxidant enzymes and cytokines in Japanese quail. Eighty Japanese quails (Coturnix japonica) (45 days old) were randomly divided into four groups (20 birds for each) with 4 replicates (5 birds each). Birds in the first group were fed a basal diet alone and served as a control (C). Birds in groups 2–4 were fed the basal diet supplemented with ZnO-NPs at doses of 15 mg/kg, 30 mg/kg and 60 mg/kg for a period of 60 days. At the end of the experiment, all birds were sacrificed to collect blood in a plain vacutainer, whereas liver and brain tissues were stored frozen at -80 °C. The obtained sera were used for the analysis of selected biochemical parameters, whereas tissue homogenates were used for the estimation of zinc, oxidative stress biomarkers and gene expression of selected antioxidant enzymes and cytokines. Results ZnO-NPs (30 and 60 mg/kg) induced a significant decrease in serum triacylglycerol (TAG) compared to the control. ZnO-NPs did not affect the activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin and tissue zinc concentrations but reduced the malondialdehyde (MDA) levels compared to the control. The liver retained a higher zinc concentration than that of brain tissue. In a dose-dependent manner, ZnO-NPs upregulated the mRNA levels of antioxidant enzymes (superoxide dismutase: SOD1; catalase: CAT; glutathione peroxidase-1: GPX 1) and pro-inflammatory cytokines (interferon α: IFN-α; interleukin 6: IL-6) in liver and brain tissues. Conclusion The current study suggests the inclusion of ZnO-NPs, particularly 60 mg/kg, in the diet of Japanese quails to improve antioxidant and immune status.

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Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications

Cited by 73 publications

References 28 publications

Neuroprotective effect of omega‐3 fatty acids on spinal cord injury induced rats

Neuroprotective effect of omega‐3 fatty acids on spinal cord injury induced rats

Green synthesis of Zinc oxide nanoparticles (ZnO NPs) and their biological activity

Impact of dietary zinc oxide nanoparticles on selected serum biomarkers, lipid peroxidation and tissue gene expression of antioxidant enzymes and cytokines in Japanese quail

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