Biocomposites and Mineralized Tissues

Ehrlich, Hermann

doi:10.1007/978-94-007-5730-1_3

Cited by 4 publications

(2 citation statements)

References 445 publications

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“…Hydroxyapatite (HA), which belongs to the calcium phosphate family, has attracted much attention to disclose a new class of hybrid materials integrating mechanical properties and biological activity [1][2][3]. HA is biocompatible with surface-active living tissues and possesses chemical and physical similarities to the inorganic phase of human bone and teeth [4][5][6]. Various forms of HA have been employed applied to modify the surface metallic implants [7], fill and repair bone defects in tissue engendering [8], and conduct protein purification [9].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds

et al. 2019

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Three-dimensional porous nanocomposites consisting of gelatin-carboxymethylcellulose (CMC) cross-linked by carboxylic acids biopolymers and monophasic hydroxyapatite (HA) nanostructures were fabricated by lyophilization, for soft-bone-tissue engineering. The bioactive ceramic nanostructures were prepared by a novel wet-chemical and low-temperature procedure from marine wastes containing calcium carbonates. The effect of surface-active molecules, including sodium dodecyl sulfate (SDS) and hexadecyltrimethylammonium bromide (CTAB), on the morphology of HA nanostructures is shown. It is demonstrated that highly bioactive and monophasic HA nanorods with an aspect ratio > 10 can be synthesized in the presence of SDS. In vitro studies on the bioactive biopolymer composite scaffolds with varying pore sizes, from 100 to 300 μm, determine the capacity of the developed procedure to convert marine wastes to profitable composites for tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds

et al. 2019

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“…Hydroxyapatite (HAp) is the most stable form of calcium phosphate and the primary inorganic component of natural hard tissues including bone and tooth both in vertebrate animals and human [ 1 ]. It has excellent physiochemical and biological properties and integrates uniquely with organic components [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Specific Hydroxyapatite {001} Binding Heptapeptide by Phage Display and Its Nucleation Effect

Mao

Shi

et al. 2016

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With recent developments of molecular biomimetics that combine genetic engineering and nanotechnology, peptides can be genetically engineered to bind specifically to inorganic components and execute the task of collagen matrix proteins. In this study, using biogenous tooth enamel as binding substrate, we identified a new heptapeptide (enamel high-affinity binding peptide, EHBP) from linear 7-mer peptide phage display library. Through the output/input affinity test, it was found that EHBP has the highest affinity to enamel with an output/input ratio of 14.814 × 10−7, while a random peptide (RP) displayed much lower output/input ratio of 0.00035 × 10−7. This binding affinity was also verified by confocal laser scanning microscopy (CLSM) analysis. It was found that EHBP absorbing onto the enamel surface exhibits highest normalized fluorescence intensity (5.6 ± 1.2), comparing to the intensity of EHBP to enamel longitudinal section (1.5 ± 0.9) (p < 0.05) as well as to the intensity of a low-affinity binding peptide (ELBP) to enamel (1.5 ± 0.5) (p < 0.05). Transmission electron microscopy (TEM), Attenuated total Reflection-Fourier transform infrared spectroscopy (ATR-FTIR), and X-ray Diffraction (XRD) studies further confirmed that crystallized hydroxyapatite were precipitated in the mineralization solution containing EHBP. To better understand the nucleation effect of EHBP, EHBP was further investigated on its interaction with calcium phosphate clusters through in vitro mineralization model. The calcium and phosphate ion consumption as well as zeta potential survey revealed that EHBP might previously adsorb to phosphate (PO43−) groups and then initiate the precipitation of calcium and phosphate groups. This study not only proved the electrostatic interaction of phosphate group and the genetically engineering solid-binding peptide, but also provided a novel nucleation motif for potential applications in guided hard tissue biomineralization and regeneration.

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An Overview on Biomaterials: Pharmaceutical and Biomedical Applications

Naidu

Wadher

Umekar

2021

J. Drug Delivery Ther.

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The development of biomaterials have existed from around half a century and manifest its use in different fields. Biomaterials are used in living creature body, looking on its biocompatibility nature. In recent years, advances of biomaterials are showing a marked presence in the fast growing fields of pharmaceuticals and medicines. According to their availability, different types of biomaterials like metal, ceramic, polymer and their composites are used for several purpose in the body. In this review article, types of biomaterials have been discussed with their advantages, disadvantages and recent applications in the pharmaceutical field such as implants used to mimic the structure and function of tissues, dental implants, wound healing, cell regeneration, regenerative medicines, delivery of drugs and different organ regeneration. Organ regeneration leading to replacement of organs such as heart, trachea and lungs etc. by use of specific biomaterials have been reported with the diagnosis of diseases and its treatment.

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Biocomposites and Mineralized Tissues

Cited by 4 publications

References 445 publications

Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds

Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds

Identification of Specific Hydroxyapatite {001} Binding Heptapeptide by Phage Display and Its Nucleation Effect

An Overview on Biomaterials: Pharmaceutical and Biomedical Applications

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