Biodegradable cationic ε-poly-L-lysine-conjugated polymeric nanoparticles as a new effective antibacterial agent

Controlled biodegradation of polymers using nanoparticles and its application

“…Food borne diseases have become an increasingly relevant health and safety concerns in the food industry. Designed of biocompatible and biodegradable ε-poly-L-lysine (EPL)/poly(ε-caprolactone) (PCL) copolymer are made to selfassemble into monodispersed nanoparticles (NPs) which show a broad spectrum of antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis [208]. Qin et al [207] incorporated antimicrobial substances like cinnamaldehyde in poly(lactic acid)/poly(trimethylene carbonate) (PLA/PTMC) films that drives to find out better ways to extend the self-life of foods.…”

“…In order to inhibit the growth of unwanted microbes on foods, antimicrobial packaging offers a means to potentially extend the shelf life of perishable foods to maintain quality. The self-assembled NPs induce changes in bacterial osmotic pressure resulting in cell invagination to form holes and create leakage of cytoplasm [208]. Designed of biocompatible and biodegradable ε-poly-L-lysine (EPL)/poly(ε-caprolactone) (PCL) copolymer are made to selfassemble into monodispersed nanoparticles (NPs) which show a broad spectrum of antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis [208].…”

Co-delivery of doxorubicin and quercetin via mPEG–PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity

“…Several biodegradable and biocompatible nanomaterials have been designed to deliver hydrophobic drugs, such as methoxy poly (ethylene glycol) and poly(D, L-lactide-co-glycolide) amphiphilic copolymer (mPEG-PLGA). The constituents of this material are approved for therapeutic use by the US Food and Drug Administration (FDA) [25][26][27].…”

Synthesis and antibacterial characterization of waterborne polyurethanes with gemini quaternary ammonium salt

“…Currently, most common approaches are utilized by impregnation with biocides, such as antibiotics [5] and triclosan [6], which are released to kill bacteria in the surrounding environment. However, these methods have only short-term antibacterial activity [7], and the long-term constant and unnecessary release of biocides could cause unpredictable long-term problems directly [8] or by their metabolites [9], even the resistant bacteria [7,10]. Tremendous research efforts have been devoted to development of alternative antibacterial therapeutics that are not easily forming resistance, such as quaternary ammonium salts (QAS) [11,12], antimicrobial peptides [13], Ag [14] and guanidine polymers [15], which destruct cell membrane of bacteria and induce the leakage of intracellular components from bacterial cells.…”