Biodegradable hydrogel‐based biomaterials with high absorbent properties for non‐adherent wound dressing

Abstract

Dressing materials involve conventional gauzes and modern materials such as hydrogels and foam-based biomaterials. Although the choice of dressing material depends on the type of wound, a dressing material is expected to be non-cytotoxic. Additionally, moist dressing is considered appropriate to accelerate epithelialisation, while dry dressing may cause tissue damage during removal. An ideal dressing material is expected to provide a moist environment and degrade and release the drug for faster wound healing. Thus, we have designed a hydrogel-based biodegradable dressing material to provide the moist environment with no cytotoxic effect in vitro. The design of the hydrogel involved alginate-collagen reinforced with whisker cellulose derived from cotton. The hydrogel was prepared via amide linkage in the presence of 1-ethyl-(dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysulfosuccinimide (NHS), followed by divalent cationic cross-linking of alginate and hydrogen bonding with cellulose. The high water retention capability of the hydrogel enables a moist environment to be maintained in the wounded area. The constituents of the hydrogel provided a microenvironment that was suitable for cell proliferation in the vicinity of the hydrogel but inhibited cell attachment on it. The MTT assay results indicated a higher fibroblast proliferation and viability in the presence of the hydrogel.

Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering

“…Collagen blended with other biomaterials such as glycosaminoglycans (GAG), chitosan, or elastin, has been fabricated to enhance the mechanical properties of the scaffolding materials and increase their enzymatic resistance for improved tissue engineering [ 171 , 172 ]. Collagen-based hydrogels and porous scaffolds in various formats, with or without cells and co-factors, have been applied for decades in studies of bone and cartilage repair, skin regeneration, cardiac tissue development, urinary bladder and ureter regeneration, wound dressing, and many other medical directions [ 173 – 177 ]. In addition to its tremendous roles in tissue engineering, collagen is broadly used in biomedical research especially in tumor microenvironment modeling that provides favorable stromal TME for cancer and stromal cells [ 178 ].…”

Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials

“…The results on DN hydrogels was also comparable to the dry chitin based dressings with excellent fibroblast proliferation promotion effect 85,86 . At the similar water content, the accelerated effect of the DN hydrogel was better than that of the crosslinked PEG hydrogel, collagen/alginate/cellulose composite hydrogel and glucomannan/PNVP composite hydrogel [87][88][89] . After day 3, cells contacting with hydrogels showed steady increase while cells on petri dish showed acceleration.…”

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

“…Hydrogel dressings provide a moist environment that facilitates cell migration and absorbs some exudate. Autolytic debridement without damage to epithelial cells or granulation is another advantage of hydrogel dressings (Kumar et al, 2017). The main disadvantage of hydrogel dressings is that they provide poor bacterial barrier.…”