Biodegradable Microparticles and Nanoparticles by Electrospraying Techniques

The ability to reproducibly produce and effectively collect electrosprayed polymeric microspheres with controlled morphology and size in bulk form is challenging. In this study, microparticles were produced by electrospraying polycaprolactone (PCL) of various molecular weights and solution concentrations in chloroform, and by collecting materials on different substrates. The resultant PCL microparticles were characterized by optical and electron microscopy to investigate the effect of molecular weight, solution concentration, applied voltage, working distance, and flow rate on their morphology and size. The work demonstrates the key role of a moderate molecular weight and/or solution concentration in the formation of spherical PCL particles via an electrospraying process. Increasing the applied voltage was found to produce smaller and more uniform PCL microparticles. There was a relatively low increase in the particle average size with an increase in the working distance and flow rate. Four types of substrates were adopted to collect electrosprayed PCL particles: a glass slide, aluminium foil, liquid bath, and copper wire. Unlike 2D bulk structures collected on the other substrates, a 3D tubular structure of microspheres was formed on the copper wire which could find application in the construction of 3D tumor mimics.

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“…2001a,b; Guarino et al. 2012). There is typically a stability window within which a steady cone-jet can form.…”

Section: Resultsmentioning

confidence: 99%

“…2011; Guarino et al. 2012). In addition, although the effect of collecting substrates on the physical properties of electrospun nanofibers has been undertaken (Teo and Ramakrishna 2006), no previous reports on the effect of collecting substrates on electrosprayed particle assemblies has been identified.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of polycaprolactone microspheres by electrospraying

Zhou

Cristinacce

Eichhorn

et al. 2016

Aerosol Science and Technology

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“…To date, electrospraying has been widely employed as valid alternative to gold standard technologies for a broader applicability spectrum, i.e. nanoparticles, nanostructured coating and drug loaded capsules . Only recently, nanoparticles fabricated by electrospraying have been successfully used to functionalize ECM analogues in the form of electrospun matrices able to release bioactive signals or drugs for multiscale and targeted delivery …”

Section: Introductionmentioning

confidence: 99%

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Guarino

Altobelli

Cirillo

et al. 2015

Polymers for Advanced Techs

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Electrohydrodynamics-i.e. electrospinning, electrospraying and atomization-are gaining a growing interest in drug delivery applications, because of a large number of advantages including improved therapeutic index, localized delivery/targeting and controlled drugs toxicity level. In the past, microstructured platforms fabricated by the assembly of electrospun fibers have demonstrated to exhibit interesting features as bioactive carriers including extended surface area and high molecular permeability because of fully interconnected pore architecture, thus making the opportunity to incorporate a wide range of actives/drugs for different use. In these systems, molecular release occurs via various molecular transport pathways namely diffusion, desorption and scaffold degradation which may be tuned through a careful control of fiber morphology and composition. However, several shortcomings still concern the possibility to incorporate bioactive species, not exposing molecules to fast and/or uncontrolled denaturation, thus preserving biochemical and biological fiber functionalities. In this context, additive electro spraying (AES)-i.e. integration of electrosprayed nanoparticles into electrospun fiber network-is emerging as interesting route to control "separately" release and functional properties of the scaffolds in order to support cell activities by independent cues, during the tissue formation. Here, we describe the current advances on the use of electrospraying and/or electrospinning until more innovative integrated AES approaches to design molecularly loaded platforms able to spatially and timely release active molecules for different use in tissue engineering and molecular targeting.

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“…EFDTs include a set of innovative top down technologies based on simple fabrication processes able to design innovative devices with restrained manufacturing costs but high functional complexity, with great benefits in terms of pharmaceutical applications . Among them, electrospraying, as a counterpart of electrospinning, is currently considered the gold standard process to prepare microspheres for drug delivery applications . Although different devices for controlled drug delivery have been successfully fabricated via coaxial configuration, the implementation of new setups based on the application of electrical forces to single‐fluid blending still represents a big challenge to minimize the electrofluidodynamic process complexity .…”

Section: Introductionmentioning

confidence: 99%

“…22 Among them, electrospraying, as a counterpart of electrospinning, is currently considered the gold standard process to prepare microspheres for drug delivery applications. 23 Although different devices for controlled drug delivery have been successfully fabricated via coaxial configuration, 24 the implementation of new setups based on the application of electrical forces to single-fluid blending still represents a big challenge to minimize the electrofluidodynamic process complexity. 25 Currently, new possibilities for the fabrication of advanced functional materials are emerging by the combination of electrofluidodynamics with other consolidated technologies (i.e., emulsion, selfassembly).…”

Section: Introductionmentioning

confidence: 99%

Core/shell cellulose‐based microspheres for oral administration of Ketoprofen Lysinate

Guarino

Caputo

Calcagnile³

et al. 2018

J Biomed Mater Res

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Herein, we propose the fabrication of a new carrier with core/shell structure-inner core of cellulose acetate (CA) coated by a micrometric layer of chitosan (CS)-fabricated through an integrated process, which combines Electro Dynamic Atomization (EDA) and layer-by-layer (LbL) technique. We demonstrate that CA based microspheres possess a unique capability to relevantly retain the drugs-that is, Ketoprofen Lysinate (KL)-along the gastric tract, while providing a massive release along the intestine. CS shell slightly influences the morphology and water retention under different pH conditions, improving drug encapsulation without compromising drug release kinetics. In vitro studies in simulated gastric and intestine fluids (SGF, SIF) with physiological enzymes, show a moderate release of LSK during the first 2 h (ca. 20% at pH 2), followed by a sustained release during the next 6 h (ca. 80% at pH 7). The obtained results demonstrate that CA-based microspheres hold strong potential to be used as carriers for a delayed oral administration of anti-inflammatory drugs. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2636-2644, 2018.

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Biodegradable Microparticles and Nanoparticles by Electrospraying Techniques

Cited by 25 publications

References 27 publications

Preparation and characterization of polycaprolactone microspheres by electrospraying

Preparation and characterization of polycaprolactone microspheres by electrospraying

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Core/shell cellulose‐based microspheres for oral administration of Ketoprofen Lysinate

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