Biodegradable Nanogels for Dermal Applications: An Insight

Abstract

Nanogels are hydrogels loaded with the active compounds encapsulated, or in matrix form with a size of nano regime, incorporated with cross-linked polymeric structures. Nanogels have a great capacity to administer drugs in the transdermal system. It can undergo stimulus-responsive nature which helps to obtain either controlled or sustained release of a drug due to the mucoadhesive nature of the nanogel. Stimuli-dependent response of nanogels shows its effectiveness towards anticancer, anti-inflammatory due to modified release triggered by alterations in pH, temperature, enzymes, light, and ionic content. Biodegradable polymer shows its effectiveness in the formulation of nanogel. Other potential benefits achieved by nanogel include increased drug loading ability, physical stability, improved patient compliance, accumulation at the target site, enhanced bioavailability, biocompatibility, and biodegradability which are the key points in designing an effective formulation. Herbal drugs can be effectively encapsulated and delivered by using nanogel as a carrier. This review insights the advance development, limitations, and therapeutic significance of nanogel formulations. It also highlights the release of drugs in response to stimuli. Various biodegradable polymers used in nanogel formulation are also discussed. This review helps understand the biomedical applications of nanogels in cancer drug delivery and its imaging, anti‐inflammatory therapy, antifungal and antimicrobial therapy, anti‐psoriatic therapy, transdermal delivery, ocular and protein/peptide drug delivery, and therapy.

The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery

“…Nanogels demonstrate excellent properties, with adjustable size, homogeneity, stability, low toxicity, responsiveness to stimuli (temperature, light, pH, enzymes, etc. ), and promising medicine encapsulation capacity [ 29 ]. Because of these properties, nanogels are promising for dermal and transdermal preparations and are promising new delivery systems.…”

“…Nanocarriers are applied for various biomedical applications, including diagnosis, therapy, or both of them as well as in the tissue engineering field [ 16 , 17 , 18 ]. Polymeric nanoparticles [ 19 , 20 , 21 ], inorganic nanocarriers [ 22 , 23 , 24 ], lipid nanocarriers [ 25 , 26 ], microgels [ 27 ] and the paradigm of nanogels [ 17 , 28 , 29 ], which are discussed in this review article, have been widely employed in the medical dermal delivery field; nanogels have great drug-loading capacity, better stability and result in minimal skin damage compared to other forms of gels [ 30 , 31 ].…”