Nanotechnology is defined as the study and use of structures between 1 and 100 nm in length (at least in one dimension). Due to the different properties of nanosized materials compared to the bulk material, research in nanotechnology has increased exponentially in recent years. The food sector is no exception, and nanotechnology is present in different stages of the food chain, from agriculture to food processing, supplements, or food packaging. Among them, the most active area of food nanoscience research and development is food packaging.Nanomaterials are used in packaging to improve the packaging barrier properties, to create active or intelligent packaging materials, or to enhance the properties of edible and biodegradable packaging materials. In addition to the packages itself, nanotechnology can also be used in labeling applications, like a nano-barcode. In the present chapter, all these applications and the commercialized products already in the market will be discussed.The current legislation related to nano-developments in food packaging is at different stages in different countries, and there are concerns about the safety of the use of such nanosized materials for food packaging applications. The different studies concerning the possible migration of the nanomaterials used in the packaging to the food will be reviewed.