Biodegradable synthetic polymers: Preparation, functionalization and biomedical application

Tian, Huayu; Tang, Zhaohui; Zhuang, Xiuli; Chen, Xuesi; Jing, Xiabin

doi:10.1016/j.progpolymsci.2011.06.004

Cited by 1,153 publications

(670 citation statements)

References 356 publications

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“…It is noteworthy that in many cases the protecting shells not only stabilize the nanoparticles, but can also be used for further functionalization, for instance with other nanoparticles or various ligands, depending on the desired application 6 . For biomedical applications, properties like biodegradability and biocompatibility are required 7 . Some polymers are used for the coating of magnetic nanoparticles, like PEG, PVA, PVP, PLGA, dextran, chitosan among others.…”

Section: Introductionmentioning

confidence: 99%

Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres

et al. 2015

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Poly(glycolide-co-lactide) (PLGA) nanospheres containing magnetic materials have been extensively studied because of its biomedical applications. Therefore, it is very important to know thermal properties of these materials in addition to other physical properties. Thermal degradation activation energy (E α ) of PLGA nanospheres with maghemite entrapment (PLGA-Mag), PLGA nanospheres (hollow spheres) (PLGA-H) obtained by an emulsion method and unprocessed PLGA (PLGA-R) were calculated by isoconversional Vyazovkin method based on data of TG analysis in order to evaluate modifications in thermal behavior caused by nanospheres obtainment process or by maghemite entrapment. Both hydrodynamic diameter in the range of 200-250 nm and polydispersity index lower than 0.3 are considered satisfactory. Thermal degradation of PLGA-R begins at higher temperatures than those of PLGA-H and PLGA-Mag, but processed samples presented increase in thermal stability, which was greater before processing by emulsion and in the presence of the magnetic materials. PLGA-Mag presents superparamagnetic behavior at room temperature.

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Section: Introductionmentioning

confidence: 99%

Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres

et al. 2015

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“…Biodegradation of polymers is influenced by factors such as chemical structure and composition, molecular weight distribution, administration route, physical factors (shape, size, defects), and degradation mechanism (enzymatic, hydrolysis, and microbial). [316] Compared to natural polymers, synthetic polymers provide longer periods of sustained release with a better drug releasing control. The most widely used synthetic polymer is PEG, which is non-toxic and prolongs blood circulation time by providing efficient hydrophilicity onto the surface of MNPs.…”

Section: Polymer Coatingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…It is a compound containing multiple copper atoms that catalyzes the single-electron oxidation of phenolic compounds with a simultaneous reduction of oxygen to water (Zhou et al 2009;Tian et al 2012). Laccase treatment of lignocellulosic fibers causes many changes to the physical and chemical properties of the fibers (GarciaUbasart et al 2012).…”

Section: Historical Developmentmentioning

confidence: 99%

“…It can oxidize the variety of organic compounds present in plant cell walls, such as lignin, ortho-and para-diphenols, aminophenols, polyphenols, aryl diamines, polyamines, and some inorganic ions . These copolymers of the cell wall exhibit an amphiphilic nature and serve as both adsorbing surfaces and adsorbable amphiphiles (Tian et al 2012). It is evident that a lignocellulosic composite can be formed successfully if the wood surface is coated with a thermoplastic cell matrix such as lignin or hemicellulose (Gradwell 2004;Kumar et al 2009;Tian et al 2012).…”

Section: Chemical Modificationmentioning

confidence: 99%

Laccase, an Emerging Tool to Fabricate Green Composites: A Review

Mahmood¹,

Hashim²,

Sulaiman³

et al. 2015

BioResources

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In the last two decades, laccases have received much attention from researchers because of their specific ability to oxidize lignin. This function of laccase is very useful for applications in several biotechnological processes, including delignification in the pulp and paper industry and the detoxification of industrial effluents from the textile and petrochemical industries. This review focuses on laccase-mediated fiberboard synthesis. Growing concerns regarding the emission of formaldehyde from wood composites has prompted industrialists to consider the fabrication of green composites. Laccase-mediated fiber treatments oxidize the lignin component without affecting the cellulose structure. As a result, free radicals are generated on the fiber surface, and these can act as potential reactive sites for further cross-linking reactions in board manufacturing. Binderless fiberboards prepared using such methods can be considered as green composites because the manufacturing process involves no additional resin.

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Biodegradable synthetic polymers: Preparation, functionalization and biomedical application

Cited by 1,153 publications

References 356 publications

Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres

Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Laccase, an Emerging Tool to Fabricate Green Composites: A Review

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