Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry

Abstract

Since magnetic nanoparticles (MNPs) have been used as multifunctional probes to diagnose and treat liver diseases in recent years, this study aimed to assess how the condition of cirrhosis-associated hepatocarcinogenesis alters the biodistribution of hepatic MNPs. Using a real-time image acquisition approach, the distribution profile of MNPs after intravenous administration was monitored using an AC biosusceptometry (ACB) assay. We assessed the biodistribution profile based on the ACB images obtained through selected regions of interest (ROIs) in the heart and liver position according to the anatomical references previously selected. The signals obtained allowed for the quantification of pharmacokinetic parameters, indicating that the uptake of hepatic MNPs is compromised during liver cirrhosis, since scar tissue reduces blood flow through the liver and slows its processing function. Since liver monocytes/macrophages remained constant during the cirrhotic stage, the increased intrahepatic vascular resistance associated with impaired hepatic sinusoidal circulation was considered the potential reason for the change in the distribution of MNPs.

Evaluation of a Balloon Implant for Simultaneous Magnetic Nanoparticle Hyperthermia and High-Dose-Rate Brachytherapy of Brain Tumor Resection Cavities

“…Treatment approaches that have been investigated involve interstitial heating technologies that can focus heat locally within an at-risk tissue volume at depth in brain. Techniques used to generate moderate temperature hyperthermia include miniature implantable radiofrequency electrodes [22][23][24], microwave antennas [25][26][27][28], hot source techniques such as DC voltage heated wires [29,30], and magnetic field excited ferromagnetic seeds [31,32] or needle-injected magnetic nanoparticles (MNPs) [33][34][35][36]. The design and typical performance of the wide range of equipment used for heating brain tumors have been reviewed previously [37][38][39].…”

On the Road to Precision Medicine: Magnetic Systems for Tissue Regeneration, Drug Delivery, Imaging, and Theranostics

“…Three additional research articles reporting on magnetic systems designed for applications to specific pathological scenarios were collected. In more detail, the study by G. A. Soares et al investigated how cirrhosis-associated hepatocarcinogenesis can alter the biodistribution of hepatic magnetic nanoparticles [ 4 ]. The researchers used a multichannel alternate current biosusceptometry system to real-time image the biodistribution of magnetic nanoparticles in the blood circulation and liver.…”