Biodistribution Study of the Anaesthetic Sodium Phenobarbital Labelled with Technetium-99m in Swiss Mice Infected with Schistosoma mansoni Sambon, 1907

Simões, Susana Balmant Emerique; Silva, José Roberto Machado e; Gutfilen, Bianca; Presgrave, Octávio Augusto França; Oliveira, Mariana Borges; Filho, Mário Bernardo

doi:10.1590/s0074-02761997000500022

Cited by 4 publications

(2 citation statements)

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“…Research shows the interference of anesthetic drugs, chemotherapy and herbals on the biodistribution of sodium pertechnetate (Na 99m TcO4). Recently, studies from our laboratory demonstrated changes in the uptake of radiopharmaceuticals in the postoperative of major surgeries involving experimental models of short bowel syndrome and bariatric surgery [19][20][21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

Untitled

Azevedo¹,

Fernandes²,

Costa³

et al. 2010

J Surg Clin Res

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Purpose: This study aimed to clarify if diabetes induced in rats changes the biodistribution of the radiopharmaceutical sodium pertechnetate (Na99mTcO4) and, consequently, the accuracy of the scintigraphic exams. Methods: We used 14 male Wistar rats, randomly allocated in 2 group: the diabetic group (D) rats (n=7) were submitted to the induction of diabetes with streptozotocin, and 7 non diabetic rats were used as controls (C). After 7 days, in the 14 animals it was administered 0,1 mL of Na99mTcO4 (0.66 MBq) through orbital plexus and, after 30 minutes, the radiopharmaceutical sodium pertechnetate was evaluated, being compared the uptske of this in the several studied organs of diabetic animals and controls. Results: The biodistribution of Na99mTcO4 was significantly higher in the liver and smaller in the bladder, thyroid and stomach of diabetic mice when compared to the control group rats. Conclusion: Diabetes induced in rats alters the biodistribution of Na99mTcO4, and this finding could have clinical implications on scintigraphic exams.

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Section: Discussionmentioning

confidence: 99%

Untitled

Azevedo¹,

Fernandes²,

Costa³

et al. 2010

J Surg Clin Res

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show abstract

“…Examinations of gastric emptying, patency of anastomoses, enterogastric reflux, hepatic and thyroid diseases, osteoporosis and metastasis, frequently are carried after bariatric surgery (Kitabaiashi et al, 2002;Fonseca et al, 2000;Badiali et al, 2001;Obradovic et al, 2000). Several works have studied the relationship between chemotherapy, phytotherapy and other drugs with the biodistribution of sodium pertechnetate (Braga et al, 2000;Oliveira et al, 2002;Gomes et al, 1998;Ripoll-Hamer et al, 1995;Simões et al, 1997;Feliciano et al, 2002, Abreu et al, 2006., Santos et al, 1995. With regard to potential consequences of bariatric surgery in the biodistribution of radiopharmaceuticals, little or no study was published until now.…”

Section: Introductionmentioning

confidence: 99%