Streptozotocin (STZ) and schistosomiasis mansoni change the biodistribution of radiopharmaceutical sodium 99m Tc-pertechnetate in mice

Góes, Vanessa Coelho; Neves, Renata Heisler; Arnóbio, Adriano; Bernardo-Filho, Mário; Machado-Silva, José Roberto

doi:10.1016/j.nucmedbio.2016.06.003

Cited by 4 publications

(5 citation statements)

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“…Following SPECT analysis, we showed that the uptake of Na 99m TcO 4 by thyroid cells decreased significantly in group 5 (continued 100 HI administration). 15 After 4 weeks of adjusted iodide intake, 1,25(OH) 2 D 3 supplementation, or both, the results showed significant improvement in Na 99m TcO 4 thyroid uptake percentages. Franken et al studied 6–8-week-old mice injected intraperitoneally with approximately 250–300 mBq of Na 99m TcO 4 and 2 mg NaI after 20 min, which resulted in a decrease in thyroid uptake percentages.…”

Section: Discussionmentioning

confidence: 89%

The protective effect of iodide intake adjustment and 1,25(OH)₂D₃ supplementation in rat offspring following excess iodide intake

Wang

Liu

Hua

et al. 2020

Therapeutic Advances in Endocrinology

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Background: In this study, we aimed to investigate the effect of iodide intake adjustment, 1,25(OH)2D3 supplementation, or both, on the thyroid gland of rat offspring. Methods: The offspring of female rats administered 100 times the normal dose of iodide (100 HI; 750 μg/d) during pregnancy and lactation were divided into four different treatment groups. They were either having their iodide intake adjusted from 100 HI to normal iodide intake (7.5 μg/day) or supplemented with 25-hydroxy vitamin D3 [1,25(OH)2D3; 5 μg·kg−1·day−1], or both, for 4 weeks. Thyroid sodium pertechnetate (Na99mTcO4) uptake percentages were measured using single-photon emission computed tomography, while serum levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and vitamin D3 (VD3) were monitored using enzyme-linked immunosorbent assay. The messenger ribonucleic acid expression of interleukin (IL)-17A, interferon gamma (IFN-γ), and IL-10 in the thyroid gland was measured using quantitative real-time polymerase chain reaction, while the protein expression of thyroid-hormone-receptor α1 (TRα1) and thyroid-hormone-receptor β1 (TRβ1) in the thyroid gland was detected using Western blotting. Haematoxylin and eosin (H & E) and immunofluorescence staining were also used to assess thyroid follicular structure and lymphocytic infiltration in the thyroid glands. Results: The immunofluorescence staining showed CD4+ co-localized with TRβ1 or the vitamin D receptor in thyroid gland cells of rats that were continuously treated with 100 HI. Following iodide adjustment, 1,25(OH)2D3 supplementation, or both, an increase in serum levels of FT3, free thyroxine, and VD3, protein expression of TRα1 and TRβ1 in the thyroid gland cells, and Na99mTcO4 thyroid uptake percentages was observed. The mRNA expression levels of IL-17A and IFN-γ, decreased, while the mRNA expression levels of IL-10 increased in the thyroid cells of each treatment group, except the group with continuous 100 HI intake. Conclusion: Iodide adjustment, 1,25(OH)2D3 supplementation, or both may increase the serum levels of FT3, FT4, and VD3, as well as the protein expression levels of TRα1 and TRβ1, in thyroid cells. In addition, iodide adjustment, 1,25(OH)2D3 supplementation, or both, may potentially reverse the imbalance in pro-inflammatory and anti-inflammatory cytokines (IL-17A, IFN-γ, and IL-10) caused by 100 HI, which may be beneficial in improving Na99mTcO4 thyroid uptake percentages.

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Section: Discussionmentioning

confidence: 89%

The protective effect of iodide intake adjustment and 1,25(OH)₂D₃ supplementation in rat offspring following excess iodide intake

Wang

Liu

Hua

et al. 2020

Therapeutic Advances in Endocrinology

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“…Then, the animals were killed (CO 2 asphyxiation) (CONCEA, 2013), and the organs (bowel, stomach, thyroid, brain, pancreas, bone, kidney, lung, liver, heart, seminal vesicle, bladder, testis, spleen, muscle, penis, and prostate) were isolated. A well counter was used to determine the radioactivity, and the percentages of the injected radioactivity per gram (%ATI/g) in each organ calculated [28].…”

Section: Administration Of the Radiopharmaceutical Na 99m Tcomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In experimental designs, the course of a drug (synthetic and natural) treatment or even WBV intervention can be evaluated with the effect on the radiopharmaceutical distribution [27,28]. Sodium pertechnetate (Na 99m TcO 4 ) is an example of a radiopharmaceutical used in clinical [29,30] and experimental approaches [28,31,32]. Furthermore, parameters, such as food intake, body mass, and stool consistency could also support understanding the effects of the current intervention, as they have been verified with some medicinal plants, and Coriandrum sativum [15] and Chenopodium ambrosioides [33].…”

Section: Introductionmentioning

confidence: 99%

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Biological Effects of Paullinia cupana (Guarana) in Combination with Whole-Body Vibration Exercise in Wistar Rats

et al. 2020

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In addition to its nutritional value, Paullinia cupana (guarana) is commonly used in traditional medicine, known for its stimulant and medicinal properties. This investigation evaluated the effects of a guarana extract in combination with whole-body vibration (WBV) exercises on Wistar rats. Rats (male, n = 20) were divided into the following four groups: control (CON), treated with guarana (GUA), submitted to 50 Hz of WBV (WBV-E), treated with guarana and submitted to 50 Hz of WBV (GUA + WBV-E), daily for 6-weeks. Guarana altered (p < 0.05) the uptake of the radiopharmaceutical sodium pertechnetate (Na99mTcO4) in muscle. Additionally, it modified the stool consistency, and in combination with WBV decreased the food intake without modifying body mass. The levels of calcium increased in the groups submitted to WBV exercises (WBV-E and GUA + WBV-E) as compared with the GUA group. The outcomes provide additional evidence of the biological effects of guarana separately or in combination with WBV and supports the use of guarana as a functional food.

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“…In experimental investigations, the course of a plant extract therapy or even WBV intervention can be guided through the altered distribution of a radiopharmaceutical [22,23]. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is widely used in experimental investigations [24]. In addition, physiological parameters as body mass, food intake and stool consistency help to understand which changes the concomitant intervention can provide in the long term [25].…”

Section: Introductionmentioning

confidence: 99%

Effects of Coriandrum sativum L. in Association with Physical Exercise in Alloxan-Induced Type 1 Diabetes Mellitus in Rats

et al. 2019

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Featured Application: The concomitant treatment proposed by this study could be an important therapeutic tool used to improve the complications arising from type 1 diabetes mellitus and could provide a clinical alternative for those individuals that currently only have the pharmacological path.Abstract: The treatment of type 1 diabetes mellitus (T1DM) is a health challenge and new approaches to solve this issue have been proposed. This study evaluated the biological effects of a concomitant treatment with Coriandrum sativum (coriander) and whole-body vibration (WBV) exercise on rats with T1DM. It is hypothesized that this concomitant treatment will improve the metabolic state of rats with T1DM. T1DM was induced with alloxan. Male rats (n = 20) were divided into four groups: control (CON), treated with coriander (COR), exposed to 50 Hz of WBV (WBV), and treated with coriander and exposed to 50 Hz of WBV (COR + WBV), weekly for 28 days. No alterations were observed in the metabolic outcome variables relating to the organs, specific biomarkers, body mass, food intake, and stool consistency. Alloxan-induced T1DM resisted desirable therapeutic effects of the proposed concomitant treatment as it inhibited antidiabetic activity of the coriander. Putting together all findings, neither coriander nor WBV exercise were capable of improving the metabolic state of the Wistar rats with T1DM. This data set and the knowledge in the literature about the effects of the concomitant treatment in healthy animals can provide greater reliability concerning the effects of coriander.

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Streptozotocin (STZ) and schistosomiasis mansoni change the biodistribution of radiopharmaceutical sodium 99m Tc-pertechnetate in mice

Cited by 4 publications

References 57 publications

The protective effect of iodide intake adjustment and 1,25(OH)₂D₃ supplementation in rat offspring following excess iodide intake

The protective effect of iodide intake adjustment and 1,25(OH)₂D₃ supplementation in rat offspring following excess iodide intake

Biological Effects of Paullinia cupana (Guarana) in Combination with Whole-Body Vibration Exercise in Wistar Rats

Effects of Coriandrum sativum L. in Association with Physical Exercise in Alloxan-Induced Type 1 Diabetes Mellitus in Rats

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Streptozotocin (STZ) and schistosomiasis mansoni change the biodistribution of radiopharmaceutical sodium 99m Tc-pertechnetate in mice

Cited by 4 publications

References 57 publications

The protective effect of iodide intake adjustment and 1,25(OH)2D3 supplementation in rat offspring following excess iodide intake

The protective effect of iodide intake adjustment and 1,25(OH)2D3 supplementation in rat offspring following excess iodide intake

Biological Effects of Paullinia cupana (Guarana) in Combination with Whole-Body Vibration Exercise in Wistar Rats

Effects of Coriandrum sativum L. in Association with Physical Exercise in Alloxan-Induced Type 1 Diabetes Mellitus in Rats

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Product

Resources

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The protective effect of iodide intake adjustment and 1,25(OH)₂D₃ supplementation in rat offspring following excess iodide intake

The protective effect of iodide intake adjustment and 1,25(OH)₂D₃ supplementation in rat offspring following excess iodide intake