Bioengineering of nano metal-organic frameworks for cancer immunotherapy

Chong, Gaowei; Zang, Jie; Han, Yi; Su, Runping; Weeranoppanant, Nopphon; Dong, Haiqing; Li, Yongyong

doi:10.1007/s12274-020-3179-9

Cited by 48 publications

(31 citation statements)

References 148 publications

(150 reference statements)

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“…A vast variety of materials, including mesoporous silica materials (MSMs) 20 , 21 , layered doubele hydroxides (LDHs) 22 , metal–organic frameworks and their composites 18 , 23 , covalent organic frameworks and their composites 24 – 26 , Fe 2 O 3 nanoparticles 28 , 29 , single-and multi-walled carbon nanotubes 30 , 31 , and graphene and graphene oxide-based materials 32 , 33 have been utilized as an adsorbent to separate or remove the organic molecules like hydrocarbons, drugs and dyes. Among those adsorbents, MSMs-based adsorbents have shown excellent performance due to their environment-friendly water-based synthesis methods (sol–gel process), porous structure, large surface area, high pore volume, designable structure and morphology, functionalizable surface, good chemical and thermal stability, and reusability 19 – 21 , 34 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of multi-organo-functionalized fibrous silica KCC-1 for highly efficient adsorption of acid fuchsine and acid orange II from aqueous solution

Soltani

Pelalak

Pishnamazi

et al. 2021

Sci Rep

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Multi-functionalized fibrous silica KCC-1 (MF-KCC-1) bearing amine, tetrasulfide, and thiol groups was synthesized via a post-functionalization method and fully characterized by several methods such as FTIR, FESEM, EDX-Mapping, TEM, and N2 adsorption–desorption techniques. Due to abundant surface functional groups, accessible active adsorption sites, high surface area (572 m2 g−1), large pore volume (0.98 cm3 g−1), and unique fibrous structure, mesoporous MF-KCC-1 was used as a potential adsorbent for the uptake of acid fuchsine (AF) and acid orange II (AO) from water. Different adsorption factors such as pH of the dye solution, the amount of adsorbent, initial dye concentration, and contact time, affecting the uptake process were optimized and isotherm and kinetic studies were conducted to find the possible mechanism involved in the process. For both AF and AO dyes, the Langmuir isotherm model and the PFO kinetic model show the most agreement with the experimental data. According to the Langmuir isotherm, the calculated maximum adsorption capacity for AF and AO were found to be 574.5 mg g−1 and 605.9 mg g−1, respectively, surpassing most adsorption capacities reported until now which is indicative of the high potential of mesoporous MF-KCC-1 as an adsorbent for removal applications.

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Section: Introductionmentioning

confidence: 99%

Synthesis of multi-organo-functionalized fibrous silica KCC-1 for highly efficient adsorption of acid fuchsine and acid orange II from aqueous solution

Soltani

Pelalak

Pishnamazi

et al. 2021

Sci Rep

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“…MOFs, an emerging class of nanocarriers, have become powerful tools for cancer immunotherapeutics with improved stability, efficacy, and safety. [77,78] MOFs can be also engineered in bidimensional structures. Cationic W-TBP NSs (composed of W 6+ ions and the photosensitizer 5,10,15,20-tetra(p-benzoato) porphyrin, TBP) could mediate PDT to release tumor-associated antigens and deliver CpG, loaded onto the sheets, to DCs.…”

Section: Metal-organic Frameworkmentioning

confidence: 99%

Recent Advances in 2D Material‐Mediated Immuno‐Combined Cancer Therapy

Bianco

2021

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metal carbides or nitrides. [3][4][5][6][7][8] Based on their different properties, such 2D materials could be used as efficient means for drug delivery, photothermal therapy (PTT, which utilizes photothermal agents to convert light energy into hyperthermia, leading to the thermal ablation of cancer cells), photodynamic therapy (PDT, which uses photosensitizers to transfer photon energy into reactive oxygen species, provoking cancer cell death), chemodynamic therapy (CDT, which is based on Fenton or Fenton-like reactions to convert H 2 O 2 into hydroxyl radicals triggering apoptosis and inhibiting tumor growth), radiotherapy (RT, which uses high-dose radiation to kill cancer cells and eliminate tumors), radiodynamic therapy (RDT, which utilizes ionizing radiation to excite photosensitizers to generate 1 O 2 against cancer), and specific combination thereof. [8][9][10] In the years, cancer immunotherapy gets exceptional growing progress, especially after ipilimumab obtained the approval from FDA. [11] Ipilimumab is a monoclonal antibody directed towards cytotoxic T-lymphocyte-associated protein 4 (CTLA4) showing a significant increase in the survival of patients with metastatic melanoma. It is well known that cancer immunotherapy is based on immune system activation to target and eradicate cancer cells with durable antitumor responses and less metastasis and recurrence than other therapeutic strategies. [12,13] Immune biochemical factors, vaccines, checkpoint inhibitors, monoclonal antibodies, and other molecules have been widely utilized as efficient modulators to activate the immune system. Checkpoint blockade immunotherapy is a recently developed strategy based on the use of checkpoint inhibitors to arrest the immunosuppressive pathways promoting antitumor T cell activation and maintaining the antitumor T cell effector function. [14,15] However, the cancer immunotherapy efficiency is still not satisfactory. Indeed, the overall patient response rates are usually below 40% by checkpoint inhibitor therapy. [16] Meanwhile, immunotherapy can trigger mild to serious side effects, such as nausea, vomiting, lung/skin/gastrointestinal/renal toxicities, hypothyroidism, arthralgia, vasculitis, autoimmune hepatitis, and other dysfunctions. [17,18] To reduce or to overcome the side effects caused by immunotherapy, and further enhance its efficiency, 2D materials provide incomparable advantages, including high specific surface area, biocompatibility, chemical surface modification, targeting possibility, tumor accumulation, and unique physicochemical In the last years, cancer immunotherapy has started to attract a lot of attention, becoming one of the alternatives in the clinical treatment of cancer. Indeed, one of the advantages of immunotherapy is that both primary and distant tumors can be efficiently eradicated through a triggered immune response. Due to their large specific surface area and unique physicochemical properties, 2D materials have become popular in cancer immunotherapy, especially as efficient drug carriers. ...

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“…Metal-organic frameworks (MOFs), a family of porous crystalline inorganic-organic self-assembled complexes, are excellent functional materials for diverse applications, including drug delivery, biosensing, catalysis, and gas separation. [19][20][21][22] In particular, their porosity and large surface area have enabled MOFs to serve as unique nanocarriers for the delivery of various proteins and enzymes while maintaining biological activity. 23,24 Moreover, by selecting suitable organic ligands such as pyrene, porphyrin, or imidazole, diverse MOFs with desirable physicochemical properties can be obtained.…”

Section: Introductionmentioning

confidence: 99%