Biofilm mitigation by drug (gentamicin)-loaded liposomes promoted by pulsed ultrasound

Ma, Dong; Wu, Junru

doi:10.1121/1.4972336

Cited by 10 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This inhibition could be maintained during 6 h, while no inhibition was observed in the case of free nisin at this time. In another work, Ma and Wu (2016) prepared gentamicinloaded liposomes to penetrate into alginate-based Ralstonia insidiosa biofilm in the presence of acoustic streaming created by pulsed ultrasound. The ultrasound pushed the liposomes into alginate-based biofilm.…”

Section: Antibacterial Nanoparticles Against Biofilm Bacteriamentioning

confidence: 99%

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

et al. 2020

View full text Add to dashboard Cite

Section: Antibacterial Nanoparticles Against Biofilm Bacteriamentioning

confidence: 99%

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

et al. 2020

View full text Add to dashboard Cite

“…Bacteria were efficiently eradicated using gentamicin containing liposomes following ultrasonic treatment. [74,75] The authors also noted that non-focused US increases liposome penetration into the biofilm, [74] and that focused US efficiently bursts the liposomes, thus releasing the contained drugs. [75]…”

Section: Liposomesmentioning

confidence: 99%

Different Aspects of Using Ultrasound to Combat Microorganisms

Nakonechny

Nisnevitch

2021

Adv Funct Materials

View full text Add to dashboard Cite

Growing resistance of microorganisms to antibiotics due to their widespread use has led to multiple bacterial infections posing a serious threat to health and human life. Low-frequency ultrasound is one of physical methods for inactivation of pathogenic microbial cells. Application of ultrasound is safe, demonstrates good tissue penetration without significant attenuation of energy, and does not induce microbial resistance. Bactericidal effect of ultrasound is based on acoustic cavitation-the growth and collapse of microbubbles in a liquid medium, resulting in shock waves, shear forces, and microjets which cause irreversible damage and inactivation of microorganisms. The present review combines and analyzes literature data on in vitro and in vivo studies and summarizes works demonstrating the ability of ultrasound, alone or in combination with other methods, to combat pathogenic microorganisms. The results of various studies presented in this review show that low-frequency ultrasound has a noticeable antimicrobial effect on planktonic cells of microorganisms and biofilms. Ultrasound synergistically enhances the effectiveness of other antibacterial agents and activates molecules called sonosensitizers, resulting in the formation of compounds toxic to microbial cells. Ultrasound can also promote local release of antimicrobial drugs from liposomes, as well as from medical implants.

show abstract

“…In another work [29], the authors showed that the focused US and gentamicin-encapsulated liposomes reduced the number of viable bacteria in alginate-based Ralstonia insidiosa biofilms by approximately 72%, compared to US alone, gentamicin in solution alone (no liposomes) and gentamicin in solution with high-intensity focused US. These data show that high-intensity focused US in combination with an antibiotic strategy can kill bacteria within synthetic alginate biofilms, while non-focused US was able to increase the attachment of liposomes to the biofilm, as demonstrated by the same authors [30].…”

Section: Exogenous Stimuli-responsive Antibiotic Drug-delivery Sysmentioning

confidence: 99%

Recent Developments in Antibacterial Therapy: Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles

et al. 2019

View full text Add to dashboard Cite

Conventional drugs used for antibacterial therapy display several limitations. This is not due to antibiotics being ineffective, but rather due to their low bioavailability, limited penetration to sites of infection and the rise of drug-resistant bacteria. Although new delivery systems (e.g., nanoparticles) that are loaded with antibacterial drugs have been designed to overcome these limitations, therapeutic efficacy does not seem to have improved. Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects. These stimuli can either be exogenous (e.g., light, ultrasound) or endogenous (e.g., pH, variation in redox gradient, enzymes). This promising therapeutic approach relies on advances in materials science and increased knowledge of microorganism growth and biofilm formation. This review provides an overview in the field of antibacterial drug-delivery systems and nanoantibiotics that benefit from a response to specific triggers, and also presents a number of future prospects.

show abstract

Biofilm mitigation by drug (gentamicin)-loaded liposomes promoted by pulsed ultrasound

Cited by 10 publications

References 10 publications

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

Different Aspects of Using Ultrasound to Combat Microorganisms

Recent Developments in Antibacterial Therapy: Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles

Contact Info

Product

Resources

About