Biogenesis, Functions, and Role of CircRNAs in Lung Cancer

Abstract

CircRNAs, a class of endogenous non-coding RNAs with closed-loop structures, have attracted increasing attention because of their good stability, high specificity of tissue expression, long half-life, and highly conserved sequence. CircRNAs have multiple biological functions, including miRNA sponge, transcription regulator, protein translation, interaction with protein, RNA maturation, and so on. These functions indicate the important role of circRNAs in tumorigenesis and malignant progression and their potential as potent diagnostic biomarkers and therapeutic molecules. In recent years, an increasing body of evidence suggests that circRNAs play a crucial role in proliferation, migration, invasion, and apoptosis of lung cancer cells. Therefore, circRNAs have gradually become a research focus in the diagnosis and treatment of lung cancer patients. This review summarizes the classification, biogenesis, and function of circRNAs, and discusses the role of circRNAs in the diagnosis, prognosis, and treatment of lung cancer patients.

Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR‐6751‐3p to regulate the expression of ZNF300

“…The functions of circ_0002360 in chemoresistance and carcinogenesis were correlated with the expression change of ZNF300 in lung cancer. CircRNAs are known to serve as miRNA inhibitors to mediate gene levels in biological regulation of lung cancer 25 . Circ_0001361 has been found to be dependent on the miR‐525‐5p/VMA21 axis to promote tumorigenesis and progression of lung adenocarcinoma 26 .…”

“…CircRNAs are known to serve as miRNA inhibitors to mediate gene levels in biological regulation of lung cancer. 25 Circ_0001361 has been found to be dependent on the miR‐525‐5p/VMA21 axis to promote tumorigenesis and progression of lung adenocarcinoma. 26 Interfering circ_00014130 reduced chemoresistance and malignance in docetaxel‐resistant NSCLC cells through interacting with the miR‐545‐3p/YAP1 network.…”

Circ-NT5C2 stimulates FZD4 expression to promote the malignant progression of osteosarcoma by targeting miR-488-3p

“…As reported, the abnormal expression of circRNAs was related to the pathogenesis of many diseases [4,10]. CircRNAs could interfere with disease progression by affecting various biological functions such as cell proliferation, metastasis, metabolism and chemotherapy resistance [6,24,25]. For example, Huang et al proved that circ-cESRP1 suppressed TGF-β signal pathway via absorbing miR-93-5p, thereby enhanced the chemosensitivity of small cell lung cancer cells [12].…”