Bioimprinting Based Scaffold Development for Tissue Engineering Applications

Narayanamurthy, Vigneswaran; Samsuri, Fahmi; K, Nithya Kalyani

doi:10.13005/bpj/618

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…69 The study proceeded to characterise the ideal properties of scaffold used in implants, and demonstrates the promise of such bioimprinting approach on cell growth. 74 Tan et al also report the imprinting of Ishikawa endometrial cancer cells, in this case using polymethacrylate (pMA) and polystyrene (pST). 71 The studies compared a culture of cells on each bioimprint type and compared them to those on flat (non-imprinted) substrates.…”

Section: Cell Culture Platformsmentioning

confidence: 97%

“…68 Vigneswaran et al proposed bioimprinted substrates to be scaffolds for the development of tissue engineering technology. 69,74 The studies both imprinted Ishikawa endometrial cancer cells into a UV fast-cure polymer. The results replicated studies showing the topology of the bioimprint to be representative of template cells on a micro and nanoscale.…”

Section: Cell Culture Platformsmentioning

confidence: 99%

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Cancer bioimprinting and cell shape recognition for diagnosis and targeted treatment

et al. 2017

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Cancer incidence and mortality have both increased in the last decade and are predicted to continue to rise. Diagnosis and treatment of cancers are often hampered by the inability to specifically target neoplastic cells. Bioimprinting is a promising new approach to overcome shortfalls in cancer targeting. Highly specific recognition cavities can be made into polymer matrices to mimic lock-and-key actions seen in in vivo biological systems. Early studies concentrated on molecules and were inhibited by template size complexity. Surface imprinting allows the capture of increasingly complex motifs from polypeptides to single cell organisms and mammalian cells. Highly specific cell shape recognition can also be achieved by cell interaction with imprints that can be made into polymer matrices to mimic biological systems at a molecular level. Bioimprinting has also been used to achieve nanometre scale resolution imaging of cancer cells. Studies of bioimprint-based drug delivery on cancer cells have been recently trialled in vitro and show that this approach can potentially improve existing chemotherapeutic approaches. This review focuses on the possible applications of bioimprinting with particular regards to cancer understanding, diagnosis and therapy. Cell imprints, incorporated into biosensors can allow the limits of detection to be improved or negate the need for extensive patient sample processing. Similar cell imprinting platforms can be used for nanoscale imaging of cancer morphology, as well as to investigate topographical signalling of cancer cells in vitro. Lastly, bioimprints also have applications as selective drug delivery vehicles to tumours with the potential to decrease chemotherapy-related side effects.

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Section: Cell Culture Platformsmentioning

confidence: 97%

Section: Cell Culture Platformsmentioning

confidence: 99%

Cancer bioimprinting and cell shape recognition for diagnosis and targeted treatment

et al. 2017

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“…From table 1, it can 8 Tetraethoxysilane Sol-gel [46,74] also be concluded that the investigation based on nanoparticle composite for cell imprint replica fabrication process has not been reported. As far as applications like cell guiding [31,48], cell adhesion [49,50], regenerative medicine [51,52], cell or tissue microenvironments [53][54][55], implants [56], bone-tissue engineering [18], tissue engineering [57][58][59][60], cell fate [16,34,61], drug delivery [54] and smart culture substrates [60,[62][63][64] are concerned, property tailoring of the biomimetic bioreplicated materials is highly demanding. Thus, doping of nanoparticles can help to modify the physical, chemical, mechanical and electrical properties of the fabricated composites for bio-replicated biomimetic applications.…”

Section: Cell Replication and Techniquesmentioning

confidence: 99%

Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis

et al. 2019

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Cell imprint lithography (CIL) or cell replication plays a vital role in fields like biomimetic smart culture substrates, bone tissue engineering, cell guiding, cell adhesion, tissue engineering, cell microenvironments, tissue microenvironments, cell research, drug delivery, diagnostics, therapeutics and many other applications. Herein we report a new formulation of superconductive carbon black photopolymer composite and its characterization towards a CIL process technique. In this article, we demonstrated an approach of using a carbon nanoparticle-polymer composite (CPC) for patterning cells. It is observed that a 0.3 wt % load of carbon nanoparticles (CNPs) in a carbon polymer mixture (CPM) was optimal for cell-imprint replica fabrication. The electrical resistance of the 3-CPC (0.3 wt %) was reduced by 68% when compared to N-CPC (0 wt %). This method successfully replicated the single cell with sub-organelle scale. The shape of microvesicles, grooves, pores, blebs or microvilli on the cellular surface was patterned clearly. This technique delivers a free-standing cell feature substrate. In vitro evaluation of the polymer demonstrated it as an ideal candidate for biomimetic biomaterial applications. This approach also finds its application in study based on morphology, especially for drug delivery applications and for investigations based on molecular pathways.

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Bioimprinting Based Scaffold Development for Tissue Engineering Applications

Cited by 2 publications

References 13 publications

Cancer bioimprinting and cell shape recognition for diagnosis and targeted treatment

Cancer bioimprinting and cell shape recognition for diagnosis and targeted treatment

Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis

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