2019
DOI: 10.1038/s41467-019-10761-5
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Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization

Abstract: Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and the reconstruction of extracellular environment. Matrix vesicles (MVs) are a type of EVs released by bone-related functional cells, and they participate in the regulation of cell mineralization. Here, we report bioinspired MVs embedded with black phosphorus (BP) and functionalized with cell-specific aptamer (denoted as Apt-bioinspired MVs) for stimulating biomineralization. The aptamer can direct bioinspired MVs to t… Show more

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Cited by 141 publications
(112 citation statements)
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“…Another emerging technology utilizes celltargeting aptamer-modified extracellular vesicles with exosomes embedded in black phosphorus. While the aptamer directs the bioinspired extracellular vesicles towards targeted cells, the black phosphorous derived inorganic phosphate facilitates cell biomineralization [102]. This targeted technology has potential for elimination of the pre-metastatic niche and is a novel area of future chemotherapeutic research.…”
Section: Exosomes As Pre-metastatic Niche Biomarkers and Therapeutic mentioning
confidence: 99%
“…Another emerging technology utilizes celltargeting aptamer-modified extracellular vesicles with exosomes embedded in black phosphorus. While the aptamer directs the bioinspired extracellular vesicles towards targeted cells, the black phosphorous derived inorganic phosphate facilitates cell biomineralization [102]. This targeted technology has potential for elimination of the pre-metastatic niche and is a novel area of future chemotherapeutic research.…”
Section: Exosomes As Pre-metastatic Niche Biomarkers and Therapeutic mentioning
confidence: 99%
“…We believe this gap was associated with the lacking of biological cues for cell. Inspired by the previous methods (Hu et al, 2017;Li et al, 2019;Wang et al, 2019), extracellular vesicles generated from cementum related cells were supposed to load inside the biomimetic cementum, which could significantly improve the cementogenic performance.…”
Section: Discussionmentioning
confidence: 99%
“…Similar to BP nanosheets, BPQDs (5.4 nm) with rapid renal clearance showed excellent PDT effects under light irradiation and could effectively generate ROS to kill cancer cells. 63 Based on the above analysis, the excellent PTT and PDT abilities of BP nanomaterials make it a promising The advantages of BP nanomaterials for bone regeneration, including biocompatibility, 101 biodegradability, 25 drug loading, 71 and photothermal 26 and photodynamic effects. 55,68 Reproduced with permission from Liu X, Miller AL, II, Park S, et al application for promoting bone regeneration, especially in disease conditions such as cancer and infection.…”
Section: Phototherapy Effectmentioning
confidence: 99%
“…In another interesting study, Wang et al synthesized bioinspired matrix vesicles (MVs) by encapsulating BPQDs into a PLGA nanosphere and functionalizing with an osteoblast-specific aptamer. 26 The aptamer directs bioinspired MVs to targeted cells, and the increasing local PO 4 photothermal effect of BPQDs can promote bone regeneration by up-regulating expression of HSPs and alkaline phosphatase ( Figure 4C). It is well known that bioactive ions such as strontium (Sr 2+ ), magnesium, and silicon can significantly stimulate osteoblast differentiation and bone formation, and they have been widely used for tissue regeneration.…”
Section: -mentioning
confidence: 99%
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