Bioinspired red blood cell membrane-encapsulated biomimetic nanoconstructs for synergistic and efficacious chemo-photothermal therapy

Wang, Pei; Jiang, Fuquan; Chen, Biao‐Qi; Tang, Hanxiao; Zeng, Xiaojiao; Cai, Duanhua; Zhu, Mingzhi; Long, Ruimin; Yang, Dayun; Kankala, Ranjith Kumar; Wang, Shibin; Liu, Yuangang

doi:10.1016/j.colsurfb.2020.110842

Cited by 37 publications

(18 citation statements)

References 33 publications

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“…This has been shown in the work done by Rao et al, where coating hexagonal UCNPs with RBC membranes resulted in a hexagonal construct for cancer imaging [ 36 ]. Wang et al have also developed spherical bovine serum albumin (BSA) nanoconstructs that encapsulate ICG and the chemodrug gambogic acid, and when coated in RBC membranes also result in a spherical nanoconstruct for chemotherapy and PTT [ 37 ]. These examples show a uniform membrane coating on a NP core.…”

Section: Fabrication Of Rbc-derived Constructsmentioning

confidence: 99%

“…For example, Pei et al developed RBC membrane-camouflaged NPs with a polymeric core containing dimers of the chemotherapy drug paclitaxel as well as 5,10,15,20-tetraphenylchlorin (TPC) as an optical cargo for PDT [ 104 ]. On the other hand, Wang et al recently reported the design of RBC membrane-coated BSA nano-constructs loaded with ICG for PTT, and gambogic acid as a chemotherapeutic [ 37 ]. With a large number of potential optical cargos and chemotherapeutics available, the possible combinations could result in many different RBC-derived particle formulations.…”

Section: Potential Clinical Applicationsmentioning

confidence: 99%

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Phototheranostics Using Erythrocyte-Based Particles

et al. 2021

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There has been a recent increase in the development of delivery systems based on red blood cells (RBCs) for light-mediated imaging and therapeutic applications. These constructs are able to take advantage of the immune evasion properties of the RBC, while the addition of an optical cargo allows the particles to be activated by light for a number of promising applications. Here, we review some of the common fabrication methods to engineer these constructs. We also present some of the current light-based applications with potential for clinical translation, and offer some insight into future directions in this exciting field.

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Section: Fabrication Of Rbc-derived Constructsmentioning

confidence: 99%

Section: Potential Clinical Applicationsmentioning

confidence: 99%

Phototheranostics Using Erythrocyte-Based Particles

et al. 2021

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“…Breast cancer, pancreatic cancer [134] Glycol chitosan NP, NP coated with red blood cell membranes [135], carbo nanotube and graphene nanodelivery, magnetic NPs…”

Section: Gambogic Acidmentioning

confidence: 99%

Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management

et al. 2020

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Nanotechnology is the science of nanoscale, which is the scale of nanometers or one billionth of a meter. Nanotechnology encompasses a broad range of technologies, materials, and manufacturing processes that are used to design and/or enhance many products, including medicinal products. This technology has achieved considerable progress in the oncology field in recent years. Most chemotherapeutic agents are not specific to the cancer cells they are intended to treat, and they can harm healthy cells, leading to numerous adverse effects. Due to this non-specific targeting, it is not feasible to administer high doses that may harm healthy cells. Moreover, low doses can cause cancer cells to acquire resistance, thus making them hard to kill. A solution that could potentially enhance drug targeting and delivery lies in understanding the complexity of nanotechnology. Engineering pharmaceutical and natural products into nano-products can enhance the diagnosis and treatment of cancer. Novel nano-formulations such as liposomes, polymeric micelles, dendrimers, quantum dots, nano-suspensions, and gold nanoparticles have been shown to enhance the delivery of drugs. Improved delivery of chemotherapeutic agents targets cancer cells rather than healthy cells, thereby preventing undesirable side effects and decreasing chemotherapeutic drug resistance. Nanotechnology has also revolutionized cancer diagnosis by using nanotechnology-based imaging contrast agents that can specifically target and therefore enhance tumor detection. In addition to the delivery of drugs, nanotechnology can be used to deliver nutraceuticals like phytochemicals that have multiple properties, such as antioxidant activity, that protect cells from oxidative damage and reduce the risk of cancer. There have been multiple advancements and implications for the use of nanotechnology to enhance the delivery of both pharmaceutical and nutraceutical products in cancer prevention, diagnosis, and treatment.

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“…Standardization of the vessels has emerged as an important solution to optimizing nanomedicine distribution for tumor therapy. Regularization of the vessels turns the pathological phenotype of the tumor vessels into a phenotype that strongly matches that of normal completely functioning vessels by restoring the basal layer and growing pericyte distribution and eventually reducing vessel leakage (Zhang et al., 2019 ; Wang et al., 2020 ). Increasing the tumor vessel architecture could greatly reduce fluid extravasation and lower IFP, and instead restore tumor blood flow, thus working to improve nanomedicine vascular transport.…”

Section: Strategies To Modulate Tme Through Npsmentioning

confidence: 99%

Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective

et al. 2020

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Cancer immunotherapy suppresses and destroys tumors by reactivating and sustaining the tumorimmune process, and thus improving the immune response of the body to the tumor. Immunotherapeutic strategies are showing promising results in pre-clinical and clinical trials, however, tumor microenvironment (TME) is extremely immunosuppressive. Thus, their translation from labs to clinics still faces issues. Recently, nanomaterial-based strategies have been developed to modulate the TME for robust immunotherapeutic responses. The combination of nanotechnology with immunotherapy potentiates the effectiveness of immunotherapy by increasing delivery and retention, and by reducing immunomodulation toxicity. This review aims to highlight the barriers offered by TME for hindering the efficiency of immunotherapy for cancer treatment. Next, we highlight various nano-carriers based strategies for modulating those barriers for achieving better therapeutic efficacy of cancer immunotherapy with higher safety. This review will add to the body of scientific knowledge and will be a good reference material for academia and industries.

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Bioinspired red blood cell membrane-encapsulated biomimetic nanoconstructs for synergistic and efficacious chemo-photothermal therapy

Cited by 37 publications

References 33 publications

Phototheranostics Using Erythrocyte-Based Particles

Phototheranostics Using Erythrocyte-Based Particles

Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management

Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective

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