Biological Activity and Chemical Characteristics of Cordyceps militaris Powder Fermented by Several Microscopic Organisms

Abstract

The comparative effects of the fibrinolytic action, antioxidative activity, and tyrosinase inhibition of Cordyceps militaris powder and fermented Cordyceps militaris powders were investigated using several microscopic organisms. The nutritional components such as phenolic compounds, flavonoids, and minerals were also measured. The total phenolic compounds and flavonoid concentrations were highest in the Cordyceps militaris powder fermented by Aspergillus oryzae. Major minerals were K, Ca, Mg, and Zn. Native polyacrylamide gel electrophoresis (native-PAGE) analysis of the total protein patterns of Cordyceps militaris powder and fermented Cordyceps militaris powders revealed slight varietal differences. Fibrinolytic activity was highest in the Cordyceps militaris powder fermented by Bacillus subtilis and Aspergillus kawachii. The DPPH radical scavenging activity was slightly stronger in the powder fermented by Monascus purpureus; however, these samples all exhibited a relatively low activity when compared with butylated hydroxytoluene (BHT). Tyrosinase inhibition activity was stronger in the powder fermented by Aspergillus oryzae than in unfermented powder. These results may provide basic data for understanding the biological activities and chemical characteristics of Cordyceps militaris powder fermented by several microscopic organisms for the development of functional foods.

Optimization of Cordyceps sinensis fermentation Marsdenia tenacissima process and the differences of metabolites before and after fermentation

“…At present, the main ingredient of Jin-shui-bao capsule (a drug sold in the Chinese market) is Fermented C. sinensis powder. Fermented C. sinensis powder has similar efficacy to C. sinensis [ 7 , 8 ].…”

Quality control method of sterols in fermented Cordyceps sinensis based on combined fingerprint and quantitative analysis of multicomponents by single marker

“…It has also been used for the treatment of chronic hepatitis and kidney failure (Pan, Zhang, & Ni, 2013). These curative effects of Cordyceps sinensis could be attributed to their active chemical components, including nucleosides (Cheng, Zhang, & Song, 2017), sterols (Sun, Zhao, & Dang, 2016; Yuan, Wang, & Kuang, 2007), polysaccharides (Yan, Wang, & Li, 2011), amino acids (Wei, Xu, & Wu, 2014), flavonoids, and other trace elements (Ahn, Park, & Yoon, 2015; Zhao, Xie, & Wang, 2014). The types and quantities of bioactive components in fermented Cordyceps sinensis vary with the number of strains and fermentation conditions.…”

Analysis of the High-Performance Liquid Chromatography Fingerprints and Quantitative Analysis of Multicomponents by Single Marker of Products of Fermented Cordyceps sinensis

“…Moreover, modern pharmacological and clinical studies have also revealed that fermented Cordyceps sinensis can have a major impact on the treatment of chronic hepatitis and kidney failure. These curative effects could be attributed to their active chemical components, including nucleosides, polysaccharides, sterols, amino acids, flavonoids, and metal complexes [ 4 – 8 ]. The type and quantity of the bioactive ingredients in fermented Cordyceps sinensis vary with the strain and the condition of the material [ 9 , 10 ].…”