BIOLOGICAL ACTIVITY OF METHANOL EXTRACT OF Elaeocarpus mastersii KING: ANTIOXIDANT, ANTIBACTERIAL, AND α-GLUCOSIDASE INHIBITOR

Okselni, Tia; Santoni, Adlis; Dharma, Abdi; Efdi, Mai

doi:10.31788/rjc.2019.1215019

Cited by 11 publications

(3 citation statements)

References 31 publications

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“…Therefore, inhibition of α-glucosidase will be one of the most effective approaches to control diabetes (Sheikh et al, 2008). Elaeocarpus genus is used as folk medicines for diabetics and hypertensive disease (Okselni et al, 2019). Talukdar et al (2016) state that in vitro anti-diabetic activity of E. ganitrus bark extract has an inhibitory effect on the α-amylase enzyme which may be used to control high blood glucose levels.…”

Section: In Vitro Anti-diabetic Activitymentioning

confidence: 99%

Phytochemical Screening, Antioxidant, Antidiabetic and Anticancer Activities of Elaeocarpus variabilis Fruit

Balamurugan

Sridhivya

Dharani

et al. 2022

Turkish JAF Sci.Tech.

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This study focused on the determination of secondary metabolites to an evaluation of the biological activity of Elaeocarpus variabilis Zmarzty fruit extract, an endemic medicinal plant. Their total Phenolic, tannin, flavonoids, alkaloids and saponins contents were quantified and their antioxidant activity, determined by DPPH, total antioxidant, ABTS, FRAP and Fe2+ chelating activity. The ethyl acetate extract exhibited the highest radical scavenging activity. The most relevant contents in total phenolics (Gallic Acid Equivalent mg/g), tannin (Gallic Acid Equivalent mg/g), total flavonoids (Rutin equivalent mg/g), total alkaloids (Quinine equivalent mg/g), and total saponin (Diosgenin equivalent mg/g) were observed. Significant correlations were established between antioxidant activity and secondary metabolites. Though the in vitro anti-diabetic activity was carried out using -amylase and -glucosidase inhibition, this indicates that the absorption and digestion of carbohydrates would probably reduce the blood glucose levels and hence help the management of type-2 diabetes. The ethyl acetate extract exhibited the potential of anticancer activity on human HT-29 colon cancer cell line IC50 values (30.0 ± 1.0) the valuable activity that compared to doxorubicin (17.0 ± 0.5). While this is the first study concerning extract from E. variabilis, our findings highlighted the richness’ in flavonoids of those extracts and their amazing potential as a source of antioxidant, anti-inflammatory, anti-diabetic, and anticancer agents.

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Section: In Vitro Anti-diabetic Activitymentioning

confidence: 99%

Phytochemical Screening, Antioxidant, Antidiabetic and Anticancer Activities of Elaeocarpus variabilis Fruit

Balamurugan

Sridhivya

Dharani

et al. 2022

Turkish JAF Sci.Tech.

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“…Antibacterial activity was detected after incubation for 24 h at 30 o C. A clear zone of inhibition in the media was considered as an indicator of antibacterial activity. 11,12,13…”

Section: Antibacterial Activity Testingmentioning

confidence: 99%

BIOACTIVE COMPOUND FROM THE MANGROVE PLANT ENDOPHYTIC FUNGUS Diaporthe amygdali SgKB4

Handayani¹,

Wahyuningsih²,

Rustini³

et al. 2020

RJC

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Investigation of the chemical constituent and antibacterial activity of Diaporthe amygdali SgKB4, an endophytic fungal strain isolated from the West Sumatran mangrove plant Sonneratiagriffithii Kurz led to the isolation of compound 1. The isolation of compound 1 was achieved by column chromatography with step gradient polarity (SGP) method and purification by recrystallization. The structure of compound 1 was elucidated based on nuclear magnetic resonance (NMR) spectroscopy data. Based on IR, 1D, and 2D-NMR, as well as MS data, the isolated compound is cytochalasin H. This compound showed mild antibacterial activity against some pathogenic bacteria. This is the first report on the isolation of cytochalasin H from the endophytic fungus D.amygdali.

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“…Elaeocarpus mastersii King belongs to Elaeocarpus genus that spread widely in Indonesia. This plant has high total phenolic contents [16,17]. Unfortunately, the literature studies showed that the isolated compounds of E. mastersii King were limited to the compounds of anthocyanins, cucurbitacins, ellagic acid derivatives, β-sitosterol, and βsitosterol glucoside [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Isolation, identification and α-glucosidase inhibition evaluation of a phenolic compound from Elaeocarpus mastersii King leaves

Okselni,

Efdi

2024

E3S Web Conf.

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Elaeocarpus mastersii King is an Indonesian folk medicine with high phenolic content. In this study, the E. mastersii King leaves were extracted using methanol solvent through maceration. The methanol extract was continuously fractionated by the liquid-liquid extraction using hexane, dichloromethane (DCM), and ethyl acetate solvents, respectively. The DCM fraction was purified by column chromatography using Silica gel 60 and Sephadex LH-20 as the stationary phase and monitored by thin-layer chromatography. This isolation process led to obtaining a pure compound with the appearance of white crystalline powder and a melting point of 198-199℃. This compound absorbed the UV light at the wavelength of 229 and 274 nm, as well as produced the bathochromic shift by the addition of NaOH reagent indicating the aromatic compound with the hydroxyl (OH) substituent. The IR spectrum confirmed the presence of aromatic and OH groups along with other functional groups, such as carbonyl (vmax 1693 cm-1) and alkane (C-H, vmax 2953 cm-1). The NMR data suggested the isolated compound as methyl gallate. Furthermore, the m/z value of the isolated compound was 185.04416 Da [M+H]+. It confirmed the monoisotopic mass of the methyl gallate (184.0362 Da). However, biological evaluation as an α-glucosidase inhibitor showed no positive activity.

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BIOLOGICAL ACTIVITY OF METHANOL EXTRACT OF Elaeocarpus mastersii KING: ANTIOXIDANT, ANTIBACTERIAL, AND α-GLUCOSIDASE INHIBITOR

Cited by 11 publications

References 31 publications

Phytochemical Screening, Antioxidant, Antidiabetic and Anticancer Activities of Elaeocarpus variabilis Fruit

Phytochemical Screening, Antioxidant, Antidiabetic and Anticancer Activities of Elaeocarpus variabilis Fruit

BIOACTIVE COMPOUND FROM THE MANGROVE PLANT ENDOPHYTIC FUNGUS Diaporthe amygdali SgKB4

Isolation, identification and α-glucosidase inhibition evaluation of a phenolic compound from Elaeocarpus mastersii King leaves

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