Biological Activity of Synthetic d, 1-Desthiobiotin

Metabolism of Biotin and Oxybiotin by Lactobacillus pentosus 124-2

“…This effect has also been reported with L. arabinomus (Hofmann Winnick et al, 1945;Pilgrim et al, 1945;Rubin et al, 1945b).…”

“…Since there has been some controversy over the fate of oxybiotin in yeast (Rubin et al, 1945b;Hofmann, 1945;Hofmann and Winnick, 1945;Axelrod et al, 1946Axelrod et al, , 1947Hofmann et al, 1947), it was of interest to study its fate in L. pentosus 124-2. Axelrod et al (1947) have proved that oxybiotin is assimilated as such by yeast, and is not converted into biotin.…”

GROWTH PROMOTING EFFECT OF SOME BIOTIN ANALOGUES FOR CANDIDA ALBICANS

“…Previous reports by others have shown that the effect of dethiobiotin on microorganisms differs greatly with different species. For S. cerevisiae this sulfur-free analoguie of biotin was found to be quite active (Melville et al, 1943;Dittmer et al, 1944;Lilly and Leonian, 1944;Rubin et al, 1945a), but for Lactobacilluts casei it was inactive as a growth promoting agent and also inhibited the response to biotin. The work of Perlman (1948) with several species of clostridia well illustrates the differences in the effect of both dethiobiotin and oxybiotin on different species, even those within the same genus.…”

Metabolism, in the Rat, of Biotin Injected Intraperitoneally as the Avidin-Biotin Complex

“…Male, Sprague-Dawley rats (290-320 g) , which were obtained from Chordata Corp., were fed for 4' wk a biotin-free, avidin-containing test diet3 (15). These rats were then divided randomly into two groups of six each.…”