Biological Applications and Toxicity Minimization of Semiconductor Quantum Dots

Filali, Samira; Pirot, Fabrice; Miossec, Pierre

doi:10.1016/j.tibtech.2019.07.013

Cited by 83 publications

(64 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lungs, kidneys, and liver are the main organs affected by QD accumulation and subsequent toxicity, although the brain is identified to be a more resistant organ to toxic effects of QDs, encouraging additional experiments for the evaluation of various types of QDs for treating and imaging neuroregenerative diseases. [251] By developing and applying chemical, physical, and biological disciplines and innovative strategies (e.g., surface functionalization techniques), it is expected that QDs can be applicable for clinical use in the near future. These approaches should mainly focus on overcoming long-term toxicity of QDs to reach a pharmaceutical QD product in clinical and industrial translation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Quantum Dots: A Review from Concept to Clinic

Kargozar

Hoseini

Milan

et al. 2020

Biotechnology Journal

170

101

View full text Add to dashboard Cite

Quantum dots (QDs) are semiconductor materials that have gained great interest due to their unique characteristics like optical properties. They are extensively being used in different areas, including solar cells, light-emitting diodes, laser technology, as well as biological and biomedical applications. In this review, comprehensive information about different aspects of QDs is provided, including their types and classifications, synthesis approaches, in vitro and in vivo toxicity, biological applications, and potentials in clinical applications. With a focus on the biological aspects, the respective in vitro and in vivo studies are collected and presented. Various surface modifications on QDs are discussed as directly influencing their properties like toxicity and optical abilities. Given the promising results, these materials are clinically used for targeted molecular therapy and imaging. However, there are a large number of questions that should be addressed before the wide application of QDs in a clinical setting. Regarding the existing barriers to QDs, suggestions are given and discussed to present an appropriate route for the clinical use of these materials.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quantum Dots: A Review from Concept to Clinic

Kargozar

Hoseini

Milan

et al. 2020

Biotechnology Journal

170

101

View full text Add to dashboard Cite

show abstract

“…The QDs without polymer protection shows the release of toxic cadmium on exposure to ultraviolet radiation [158][159][160][161]. In vitro toxicity studies of CdSe QDs on primary hepatocytes showed acute toxicity profile due to the liberation of free Cd2+ ions [162][163][164]. SPIONs are thought to be less toxic under in vivo conditions as they are considered to be biodegradable [165,166].…”

Section: Toxicity Apprehensionmentioning

confidence: 99%

Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges

et al. 2020

View full text Add to dashboard Cite

Early detection, right therapeutic intervention, and simultaneous effectiveness mapping are considered the critical factors in successful cancer therapy. Nevertheless, these factors experience the limitations of conventional cancer diagnostics and therapeutics delivery approaches. Along with providing the targeted therapeutics delivery, advances in nanomedicines have allowed the combination of therapy and diagnostics in a single system (called cancer theranostics). This paper discusses the progress in the pre-clinical and clinical development of therapeutics, diagnostics, and theranostics cancer nanomedicines. It has been well evident that compared to the overabundance of works that claimed success in pre-clinical studies, merely 15 and around 75 cancer nanomedicines are approved, and currently under clinical trials, respectively. Thus, we also brief the critical bottlenecks in the successful clinical translation of cancer nanomedicines.

show abstract

“…QD toxicity effect depends on their chemical composition, since they can contain compounds such as Cd and Hg. QDs toxicity depends on several parameters, resultant from individual physicochemical characteristics and environmental conditions, like concentration, size, charge, coating, and oxidative, photolytic and mechanical stability (Bottrill & Green, 2011; Filali et al, 2020). Thus, while some studies show their toxicity (Hoshino et al, 2004; Lovrić et al, 2005), in other's that evidence is not demonstrated (Ballou et al, 2004; Voura et al, 2004) and there are studies where the QDs toxicity depends on the dosage used (Li et al, 2020).…”

Section: Current Limitations Of Nanomaterials In Diagnostic Biosensorsmentioning

confidence: 99%

Current nanotechnology advances in diagnostic biosensors

et al. 2020

View full text Add to dashboard Cite

Rapid, reliable and easy access diagnostics can significantly improve early detection and treatment monitoring of high mortality diseases, such as cardiovascular diseases, cancer, diabetes, among others (Rebelo et al., 2019). The successfully diagnostics of a disease, even prior to the manifestation of any symptom, can be crucial to efficacious treatment and survival rate (Chamorro-Garcia & Merkoçi, 2016).Biomarkers are frequently used to diagnose these diseases; however, they need to be quantified in a specific concentration range in physiological fluids, such as blood and urine, which is a time-consuming process that uses bulky and expensive laboratory equipment.Thus, there is a need for portable, rapid and reliable technologies that can simplify laboratory biomarker quantitation (Wu et al., 2017). In order to achieve this, a plethora of sensing mechanisms have been combined with biological elements, producing biosensor technologies, which enable the quantitation of analytes in mixtures.

show abstract

Biological Applications and Toxicity Minimization of Semiconductor Quantum Dots

Cited by 83 publications

References 101 publications

Quantum Dots: A Review from Concept to Clinic

Quantum Dots: A Review from Concept to Clinic

Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges

Current nanotechnology advances in diagnostic biosensors

Contact Info

Product

Resources

About