Biological Behaviour of Laryngeal Adenoid Cystic Carcinoma Therapeutic Considerations

Ferlito, Alfio; Caruso, Giuseppe

doi:10.1159/000275651

Cited by 11 publications

(5 citation statements)

References 16 publications

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“…Häufiger finden sich adenoidzystische Karzinome der Subglottis und der Trachea [12,6]. Die Neigung zu lymphogener Metastasierung wird als gering eingeschätzt [8,13]. Das biologische Verhalten des Tumors zeichnet sich durch ein lokal aggressives Wachstum mit perivaskulärer und perineuraler Ausbreitung aus [14,15].…”

Section: Diskussionunclassified

“…Im Unterschied zu einem isolierten Plattenepithelkarzinom ist bei diesem Kollisionstumor zu bedenken, dass adenoidzystische Karzinome wesentlich stärker zu lokoregionären Rezidiven und einer hämatogenen Metastasierung neigen und dies auch über 10 Jahre nach der Ersttherapie des Primarius auftreten kann [8,15]. Neben der hohen Wahrscheinlichkeit für die Entwicklung eines Lokalrezidivs ist daher im Rahmen der Tumornachsorge der Ausschluss einer Fernmatastasierung über 10 ± 15 Jahre hinweg notwendig.…”

Section: Diskussionunclassified

“…Die adenoidzystischen Karzinome zeigen ein rasches lokales Wachstum. Sie breiten sich insbesondere entlang neuraler und vaskulärer Strukturen aus und sind durch eine hohe lokale Rezidivneigung mit Spätmetastasierung gekennzeichnet [8,9]. Synchron wachsende Karzinome unterschiedlicher Histologie in direkter anatomischer Nachbarschaft werden als Kollisionstumoren bezeichnet.…”

Section: Introductionunclassified

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Kollisionstumor eines adenoidzystischen Karzinoms des Hypopharynx und eines Plattenepithelkarzinoms des Larynx

Kufeld

Junker²,

Sudhoff³

et al. 2004

Laryngorhinootologie

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Section: Diskussionunclassified

Section: Introductionunclassified

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Kollisionstumor eines adenoidzystischen Karzinoms des Hypopharynx und eines Plattenepithelkarzinoms des Larynx

Kufeld

Junker²,

Sudhoff³

et al. 2004

Laryngorhinootologie

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“…Conversely, distant metastases may be detected (in the lung, liver, bones, brain) in the terminal stage. A cervical mass is not always a lymph node secondary, as it may be a recurrence or persistence of the primary tumour (Ferlito and Caruso, 1983;Ferlito et al, 1990). Occasionally, a metastasis from a basaloid squamous cell carcinoma may be mistaken for an adenoid cystic carcinoma (Ferlito et al, 1997a).…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

Management of the clinically negative cervical lymph nodes in patients with non-conventional squamous carcinoma of the larynx

et al. 1999

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This paper discusses the indications for neck dissection in those patients with laryngeal tumours which prove to be, on pathologic examination, not conventional squamous carcinomas but rather fall into the category either of one of the uncommon histological subtypes of carcinoma, or another type of unusual histological variant of laryngeal malignancy, a mesenchymal tumour. It appears as though these unusual laryngeal malignancies may manifest both biological behaviours and propensities to metastasize to regional lymph nodes that differ from those of the more commonly encountered conventional squamous carcinomas of the larynx. This heterogeneous group of tumours accounts for about 10 per cent of all malignant tumours of the larynx.

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“…However, these modalities do not seem to affect mortality, which is typically the result of metastatic disease [2,4]. Prophylactic lymph node dissection is only indicated for clinically involved nodes [5,6]. ACC is characterized by an indolent growth pattern and late distant metastasis, most commonly to the lungs [2].…”

Section: Introductionmentioning

confidence: 99%

A report of laryngeal adenocystic carcinoma metastatic to the spleen and the role of splenectomy in the management of metastatic disease: a case report

et al. 2010

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IntroductionAdenoid cystic carcinoma (ACC) of the larynx is a rare malignancy characterized by an indolent course and late pulmonary metastases. Metastases from the larynx to the spleen are an unusual event. In the present report, we discuss a patient with adenoid cystic carcinoma of the larynx metastatic to the spleen. A review of the literature did not yield any other such incidents. We review the clinical presentation and course of adenoid cystic carcinoma, as well as the role of splenectomy for metastases.Case presentationWe present a case of laryngeal adenoid cystic carcinoma in a 26-year-old Caucasian man treated with total laryngectomy and ionizing radiation. He initially developed asynchronous pulmonary metastases, which were resected. Our patient subsequently presented with a symptomatic splenic lesion consistent with metastatic disease, for which he underwent laparoscopic splenectomy.ConclusionsSplenectomy might be indicated for isolated metastases. A splenectomy effectively addresses symptoms and serves as a cytoreduction modality.

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Biological Behaviour of Laryngeal Adenoid Cystic Carcinoma Therapeutic Considerations

Cited by 11 publications

References 16 publications

Kollisionstumor eines adenoidzystischen Karzinoms des Hypopharynx und eines Plattenepithelkarzinoms des Larynx

Kollisionstumor eines adenoidzystischen Karzinoms des Hypopharynx und eines Plattenepithelkarzinoms des Larynx

Management of the clinically negative cervical lymph nodes in patients with non-conventional squamous carcinoma of the larynx

A report of laryngeal adenocystic carcinoma metastatic to the spleen and the role of splenectomy in the management of metastatic disease: a case report

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