Biological effects of cannabidiol on human cancer cells: Systematic review of the literature

Valenti, Chiara; Billi, Monia; Pancrazi, Gian Luca; Calabria, Elena; Armogida, Niccolò Giuseppe; Tortora, Gregorio; Pagano, Stefano; P, Barnaba; Marinucci, Lorella

doi:10.1016/j.phrs.2022.106267

Cited by 22 publications

(11 citation statements)

References 115 publications

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“…Interest in the use of CBD to treat cancer is currently high among researchers and clinicians, as indicated by the large number of recently published articles. Several recent reviews of the topic have examined relevant aspects, including the biochemical, pharmacological, and molecular mechanisms of CBD activity in cells [ 4 , 23 ]; CBD’s mechanism-of-action in cell and mouse models of cancer treatment [ 105 , 106 ]; and its clinical use to manage cancer symptoms [ 107 , 108 ]. We have aimed to synthesize this information and identify unmet needs in the field (standard dosing and true randomization, comparison between pure CBD and CBD+THC formulations, and impact of drug combinations on CBD efficacy), which could serve as the focus for future research and, thus, hasten the clinical translation of CBD.…”

Section: Discussionmentioning

confidence: 99%

Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges

Green

Khalil

Mohapatra

et al. 2022

IJMS

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There is currently a growing interest in the use of cannabidiol (CBD) to alleviate the symptoms caused by cancer, including pain, sleep disruption, and anxiety. CBD is often self-administered as an over-the-counter supplement, and patients have reported benefits from its use. However, despite the progress made, the mechanisms underlying CBD’s anti-cancer activity remain divergent and unclear. Herein, we provide a comprehensive review of molecular mechanisms to determine convergent anti-cancer actions of CBD from pre-clinical and clinical studies. In vitro studies have begun to elucidate the molecular targets of CBD and provide evidence of CBD’s anti-tumor properties in cell and mouse models of cancer. Furthermore, several clinical trials have been completed testing CBD’s efficacy in treating cancer-related pain. However, most use a mixture of CBD and the psychoactive, tetrahydrocannabinol (THC), and/or use variable dosing that is not consistent between individual patients. Despite these limitations, significant reductions in pain and opioid use have been reported in cancer patients using CBD or CBD+THC. Additionally, significant improvements in quality-of-life measures and patients’ overall satisfaction with their treatment have been reported. Thus, there is growing evidence suggesting that CBD might be useful to improve the overall quality of life of cancer patients by both alleviating cancer symptoms and by synergizing with cancer therapies to improve their efficacy. However, many questions remain unanswered regarding the use of CBD in cancer treatment, including the optimal dose, effective combinations with other drugs, and which biomarkers/clinical presentation of symptoms may guide its use.

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Section: Discussionmentioning

confidence: 99%

Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges

Green

Khalil

Mohapatra

et al. 2022

IJMS

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“…It was reported that CBD had a variety of pharmacological activities, for example, antiepileptic, anxiolytic, anti-inflammatory, antioxidative, antitumor, neuroprotective, immunoregulatory, and antidiabetic activities. [10][11][12] The ABTS free radical scavenging ability of CBD was reported to be comparable to Vc, which indicated the strong antioxidant activity of CBD. [13] Up to now, a large number of researches have demonstrated that CBD could adjust the redox state of cells to reduce oxidative damage of the body.…”

Section: Introductionmentioning

confidence: 93%

“…Briefly, the HUVECs at logarithmic growth stage were diluted to 4 × 10 4 cells/mL. 100 μL cell suspension was added into every well of the 96-well plate and the plate was incubated for 24 h. Then 100 μL fresh medium of H 2 O 2 with different concentrations (12,18,24,30,36, and 42 μg/mL) was supplemented and the plate was cultured for another 24 h. Subsequently, 20 μL MTT solution (5 mg/mL) was added and incubated for 4 h. All solution in each well was removed and the well was washed with PBS for 2 times. Then 150 μL DMSO was added to dissolve the formazan.…”

Section: Establishment Of H 2 O 2 -Induced Huvecs Oxidative Damage Modelmentioning

confidence: 99%

“…It is noteworthy that CBD is not addictive, therefore, it can be used for humans safely. It was reported that CBD had a variety of pharmacological activities, for example, antiepileptic, anxiolytic, anti‐inflammatory, antioxidative, antitumor, neuroprotective, immunoregulatory, and antidiabetic activities [10–12] . The ABTS free radical scavenging ability of CBD was reported to be comparable to Vc, which indicated the strong antioxidant activity of CBD [13] .…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Cannabidiol on Hydrogen Peroxide‐Induced Oxidative Damage in Human Umbilical Vein Endothelial Cells (HUVECs)

Yang

Zhao

et al. 2023

Chemistry & Biodiversity

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Natural antioxidants play an important role in promoting good health because of their prevention for oxidative damage. The work aimed to explore the antioxidant mechanism and activity of cannabidiol (CBD) at the cellular level. The human umbilical vein endothelial cell (HUVEC) with oxidative damage was employed as the model to study the protective capability of CBD. The results showed that CBD pre-treatment before the cells were exposed to hydrogen peroxide (H 2 O 2 ) resulted in an obvious increase of cell viability (about 100 %) and antioxidant related enzymes activity, and a decline of malondialdehyde (MDA) level. Besides, CBD could alleviate the increase of intracellular reactive oxygen species (ROS) content, the contraction of nucleus, and condensation of chromatin. The changes showed a dose-dependent effect. Additionally, the free radicals scavenging capacity of CBD was comparable to that of typical natural antioxidant, anthocyanidins. In summary, CBD could be employed as a potent antioxidant source for avoiding the oxidative damage. These results could provide the foundation for the development of CBD antioxidant products.

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“…There is a huge diversity of cannabinoid compounds being investigated for several potential therapeutic applications, but most of the findings are still considered of limited or insufficient scientific evidence to support the conclusion that cannabis or cannabinoids are an effective or ineffective treatment for the health endpoint of interest [2]. The therapeutic effects of phytocannabinoids, mainly THC and CBD, have already been extensively reviewed for application in the treatment of several diseases [15][16][17][18][19][20][21][22].…”

Section: Therapeutic Effects Of Cannabismentioning

confidence: 99%

Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications

et al. 2023

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Supercritical carbon dioxide (CO2) extraction techniques meet all-new consumer market demands for health-promoting phytochemical compound-rich extracts produced from green and sustainable technology. In this regard, this review is dedicated to discussing is the promise of integrating high-pressure CO2 technologies into the Cannabis sativa L. processing chain to valorize its valuable pharmaceutical properties and food biomass. To do this, the cannabis plant, cannabinoids, and endocannabinoid system were reviewed to understand their therapeutic and side effects. The supercritical fluid extraction (SFE) technique was presented as a smart alternative to producing cannabis bioproducts. The impact of SFE operating conditions on cannabis compound extraction was examined for aerial parts (inflorescences, stems, and leaves), seeds, and byproducts. Furthermore, the opportunities of using non-thermal supercritical CO2 processing on cannabis biomass were addressed for industrial hemp valorization, focusing on its biorefinery to simultaneously produce cannabidiol and new ingredients for food applications as plant-based products.

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Biological effects of cannabidiol on human cancer cells: Systematic review of the literature

Cited by 22 publications

References 115 publications

Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges

Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges

Protective Effect of Cannabidiol on Hydrogen Peroxide‐Induced Oxidative Damage in Human Umbilical Vein Endothelial Cells (HUVECs)

Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications

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