Biological effects of extracts obtained from Stryphnodendron adstringens on Herpetomonas samuelpessoai

Holetz, Fabíola; Ueda-Nakamura, Tânia; Filho, Benedito Prado Dias; Mello, João Carlos Palazzo de; Morgado‐Díaz, José Andrés; Toledo, Cleyton Eduardo Mendes de; Nakamura, Celso Vataru

doi:10.1590/s0074-02762005000400010

Cited by 36 publications

(20 citation statements)

References 11 publications

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“…In contrast traditional medicines, including herbal and glandular products, appear to address the cause of many diseases and yield superior clinical results. Therefore, crude plant extracts in the form of decoction, infusion or tincture are traditionally more used by the population for the treatment of several diseases, as well as an antiinflammatory and healing agent (Holetz et al, 2005). As a general rule crude therapeutic products are less toxic than their synthetic counterparts because they contain the total family of medicinal compounds (known and unknown) just as they are found in their natural source and hence offer less risk of side effects.…”

Section: Crude Extractsmentioning

confidence: 99%

Potential Genotoxic and Cytotoxic Effects of Plant Extracts

Çelik¹

2012

A Compendium of Essays on Alternative Therapy

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Section: Crude Extractsmentioning

confidence: 99%

Potential Genotoxic and Cytotoxic Effects of Plant Extracts

Çelik¹

2012

A Compendium of Essays on Alternative Therapy

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“…Extracts of the stem bark from species of Stryphnodendron have several medically useful properties, such as antiinflammatory (Melo et al, 2007), antimicrobial Ishida et al, 2006), antiulcerogenic (Audi et al, 1999), trypanocidal (Holetz et al, 2005) Mello et al (1996a;1996b, who isolated 23 compounds from these tannins. Recently, Lopes et al (2008) reported five new compounds from stem bark of S. adstringens and S. polyphyllum.…”

Section: Introductionmentioning

confidence: 99%

“…Extracts of the stem bark from species of Stryphnodendron have several medically useful properties, such as antiinflammatory (Melo et al, 2007), antimicrobial Ishida et al, 2006), antiulcerogenic (Audi et al, 1999), trypanocidal (Holetz et al, 2005), antioxidant and cicatrizant properties, probably because of their high tannin content (about 20%) (Audi et al, 2004). The content of tannins in Stryphnodendron adstringens was demonstrated by Mello et al (1996a;1996b, who isolated 23 compounds from these tannins.…”

Section: Introductionmentioning

confidence: 99%

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

Hernandes

Pereira

Palazzo

et al. 2010

Braz. J. Pharm. Sci.

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This study evaluated the cicatrizant effect of an ointment containing 1% of the ethyl-acetate fraction extracted from the stem bark of "barbatimão" (Stryphnodendron adstringens), in wounds made in the skin of rats, after 4, 7 and 10 days of treatment. Control wounds were treated with a base ointment without extract. The proliferation of keratinocytes in the area of reepithelialization was evaluated by counting the number of epithelial cells that were blocked in metaphase by vincristine sulfate. The length of the reepithelialized margin and the contraction of the wound were measured. Topical application of the "barbatimão" ointment stimulated proliferation of the keratinocytes, but had no effect on the length of the epithelium or on the contraction of the wounds. Uniterms:Stryphnodendron adstringens/pharmacognosy. Stryphnodendron adstringens/ cicatrizant effect. "Barbatimão"/pharmacognosy. Wound/healing/experimental study. Reepithelialization.Neste estudo, avaliou-se a atividade cicatrizante de uma pomada contendo uma fração acetato de etila 1% obtida de cascas de "barbatimão" (Stryphnodendron adstringens) em feridas excisionais na pele de ratos após 4, 7 e 10 dias de tratamento. Feridas controle foram tratadas com pomada base, sem extrato. A proliferação dos queratinócitos na área reepitelizada foi avaliada através da contagem do número de queratinócitos bloqueados em metáfase, pelo sulfato de vincristina. O comprimento da margem reepitelizada e a contração das feridas foram mensurados. As feridas tratadas com barbatimão apresentaram um maior número de mitoses do que aquelas tratadas com a pomada base, em todos os tempos avaliados. A aplicação tópica da pomada de "barbatimão" estimulou a proliferação epitelial contudo não teve efeito sobre a migração dos queratinócitos ou sobre a contração das feridas. Unitermos:Stryphnodendron adstringens/farmacognosia. Stryphnodendron adstringens/efeito cicatrizante. "Barbatimão"/farmacognosia. Feridas/cicatrização/estudo experimental. Reepitelização. INTRODUCTIONIn cutaneous lesions, tannins bind to the proteins of the injured tissues, precipitating them (Fernandez et al., 2002) and creating a protective layer (Neto et al., 1996). This layer isolates the wound site from the environment, reducing the permeability and exudation of the wound (Brown, Dattner, 1998;Bedi, Shenefelt, 2002) and promoting tissue repair. Tannins also exhibit vasoconstrictor and anti-inflammatory properties (Mota et al., 1985;Kapu et al., 2001) and stimulate the growth of epidermis, aiding reepithelialization (Palermo et al., 2002;. Reepithelialization involves the proliferation and migration of cells from the edges of the wound, and is regulated by mechanisms involving genes, growth factors, integrins, extracellular matrices (ECM) and metalloproteinases (MMPs) (Santoro, Gaudino, 2005).Stryphnodendron Martius, Leguminosae, popularly known as "barbatimão", is a Brazilian savannah tree. Extracts of the stem bark from species of Stryphnodendron have several medically useful properties, such as antiinflamma...

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“…Species of this genus are utilized in popular medicine for leukorrhea and gynecologic problems, as an antibacterial, antihemorrhagic, antihypertensive or antiulcerogenic, for diarrhea and inflammatory processes, as an astringent, antiseptic or diuretic and for cleansing and healing of wounds, especially in the form of a decoction (Vasconcelos et al, 2004;Souza et al, 2007). The biological studies of the genus show that Stryphnodendron has several activities: antimicrobial (Sanches et al, 2005), antiulcer (Rodrigues et al, 2008), antiviral (Felipe et al, 2006), trypanocidal (Holetz et al, 2005) and against Candida albicans (Ishida et al, 2006).…”

Section: Research Articlementioning

confidence: 99%