Biological evaluation of micro–nano patterned implant formed by anodic oxidation

Moon, Seung-Kyun; Kwon, Jae‐Sung; Uhm, Soo-Hyuk; Lee, Eun-Jung; Gu, Hee-Jin; Eom, Tae-Gwan

doi:10.1016/j.cap.2013.12.030

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…Similar conclusions were drawn by Moon et al, who utilized surface oxidation to obtain combined micro- and nanostructures and evaluated their osseointegration in a rabbit model. They concluded that the combined structures enhanced the activity of alkaline phosphatase (ALP), and therefore stimulated the mineralization [ 203 ]. One of the important factors determining the biological response to implants is their wettability.…”

Section: Implantsmentioning

confidence: 99%

Nanotechnology for Dentistry: Prospects and Applications

Glowacka-Sobotta

Ziental

Czarczyńska-Goślińska

et al. 2023

Nanomaterials

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In the XXI century, application of nanostructures in oral medicine has become common. In oral medicine, using nanostructures for the treatment of dental caries constitutes a great challenge. There are extensive studies on the implementation of nanomaterials to dental composites in order to improve their properties, e.g., their adhesive strength. Moreover, nanostructures are helpful in dental implant applications as well as in maxillofacial surgery for accelerated healing, promoting osseointegration, and others. Dental personal care products are an important part of oral medicine where nanomaterials are increasingly used, e.g., toothpaste for hypersensitivity. Nowadays, nanoparticles such as macrocycles are used in different formulations for early cancer diagnosis in the oral area. Cancer of the oral cavity—human squamous carcinoma—is the sixth leading cause of death. Detection in the early stage offers the best chance at total cure. Along with diagnosis, macrocycles are used for photodynamic mechanism-based treatments, which possess many advantages, such as protecting healthy tissues and producing good cosmetic results. Application of nanostructures in medicine carries potential risks, like long-term influence of toxicity on body, which need to be studied further. The introduction and development of nanotechnologies and nanomaterials are no longer part of a hypothetical future, but an increasingly important element of today’s medicine.

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Section: Implantsmentioning

confidence: 99%

Nanotechnology for Dentistry: Prospects and Applications

Glowacka-Sobotta

Ziental

Czarczyńska-Goślińska

et al. 2023

Nanomaterials

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“…Previous studies indicate that macro, micro, and nano-structured surface morphologies in implant surfaces can have pivotal effects on biocompatibility, bioactivity, osteogenesis, bone formation, and integration [35,36]. It was proven by many scholars that micro/nano-structured surfaces could improve biocompatibility [37], cell adhesion and proliferation, filament orientation, and even gene expression [38], as well as alkaline phosphatase (ALP) activity, cell mineralization, and osseointegration [39]. Some of these micro/nano-structures, in addition to maintaining biocompatibility and osseointegration, can have bactericidal properties [40].…”

Section: Introductionmentioning

confidence: 99%

Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

Zhou

Attarilar

et al. 2021

Coatings

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Due to the growing aging population of the world, and as a result of the increasing need for dental implants and prostheses, the use of titanium and its alloys as implant materials has spread rapidly. Although titanium and its alloys are considered the best metallic materials for biomedical applications, the need for innovative technologies is necessary due to the sensitivity of medical applications and to eliminate any potentially harmful reactions, enhancing the implant-to-bone integration and preventing infection. In this regard, the implant’s surface as the substrate for any reaction is of crucial importance, and it is accurately addressed in this review paper. For constructing this review paper, an internet search was performed on the web of science with these keywords: surface modification techniques, titanium implant, biomedical applications, surface functionalization, etc. Numerous recent papers about titanium and its alloys were selected and reviewed, except for the section on forthcoming modern implants, in which extended research was performed. This review paper aimed to briefly introduce the necessary surface characteristics for biomedical applications and the numerous surface treatment techniques. Specific emphasis was given to micro/nano-structured topographies, biocompatibility, osteogenesis, and bactericidal effects. Additionally, gradient, multi-scale, and hierarchical surfaces with multifunctional properties were discussed. Finally, special attention was paid to modern implants and forthcoming surface modification strategies such as four-dimensional printing, metamaterials, and metasurfaces. This review paper, including traditional and novel surface modification strategies, will pave the way toward designing the next generation of more efficient implants.

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“…Biochemically, biomimetic coatings containing calcium phosphate (CaP) or bioactive molecules were reported to facilitate osteointegration. Biophysically, nanotopographies such as TiO 2 nanotubes (TNTs) could also improve the osteogenesis of titanium implants. − …”

Section: Introductionmentioning

confidence: 99%

Enzyme-Directed Biomineralization Coating on TiO₂ Nanotubes and its Positive Effect on Osteogenesis

Huang

Yun

et al. 2019

ACS Biomater. Sci. Eng.

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Hydroxyapatite (HA)-coated TiO2 nanotubes (TNTs) have been reported to enhance osteogenesis. However, the nanoscale topography of TNTs usually vanishes due to the uncontrollable mineralization on the surface. In this study, TNTs with different diameters(small, 25 nm; medium, 55 nm; and large, 85 nm) were fabricated by anodization in 3 different voltages. Enzyme-directed biomineralization was adopted to deposit calcium phosphate on the above TNTs. The surface structures and properties of the coatings were characterized by scanning electron microscopy, dispersive X-ray spectrometry, X-ray diffraction, and Fourier-transform infrared spectroscopy. The osteogenesis effect of the hybrid TNT/HA and the original TNTs were evaluated. The results showed that hydroxyapatite deposited homogeneously along the TiO2 nanotubes while preserving the intrinsic nanotopography. Mechanically, alkaline phosphatase(ALP) played a critical role in the mineralization and large nanotube size is more favorable for the mineralizing process because of more ALP absorption. Besides, the hybrid nanosurface TNT/HA coating was found to improve the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells compared to pure TNTs. Our study suggests that the hybrid TNT/HA coating constructed by enzyme-directed biomineralization on TiO2 nanotubes is a promising modification strategy for titanium implants.

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Biological evaluation of micro–nano patterned implant formed by anodic oxidation

Cited by 9 publications

References 23 publications

Nanotechnology for Dentistry: Prospects and Applications

Nanotechnology for Dentistry: Prospects and Applications

Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

Enzyme-Directed Biomineralization Coating on TiO₂ Nanotubes and its Positive Effect on Osteogenesis

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Biological evaluation of micro–nano patterned implant formed by anodic oxidation

Cited by 9 publications

References 23 publications

Nanotechnology for Dentistry: Prospects and Applications

Nanotechnology for Dentistry: Prospects and Applications

Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

Enzyme-Directed Biomineralization Coating on TiO2 Nanotubes and its Positive Effect on Osteogenesis

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Product

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Enzyme-Directed Biomineralization Coating on TiO₂ Nanotubes and its Positive Effect on Osteogenesis