“…Regarding the former, the complex picture of yeast's enzymes evidenced by Koshland [32,53], where positive and negative cooperativity appear simultaneously (and with the anticooperativity effect getting more and more pronounced as the substrate concentration is raised), still escapes from this mathematical architecture. Further, from the mechanical point of view, two weird things happen: the velocity is bounded by = 1, while in Classical Mechanics the velocity may diverge; further, if we look at the Boltzmann factor in the free energy (see (12)), this reads as exp[ (− 2 /2 + )] and, recalling that the kinetic energy in this mechanical analogy reads as 2 /2 (the mass is unitary, thus velocity and momentum coincide), we are allowed to interpret ( , , ℎ) as a real action. From this perspective, the exponent can be thought of as the coupling between the stress-energy tensor and the metric tensor: a glance at the form of the Boltzmann factor reveals that the natural underlying metric is (−1, +1) rather than (+1, +1) as in classical Euclidean frames, or in other words, it is of the Minkowskian type.…”