Biological labelling reagents and probes derived from luminescent transition metal polypyridine complexes

Lo, Kenneth Kam‐Wing; Hui, Wai-Ki; Chung, Chi-Keung; Tsang, Keith Hing-Kit; Ng, Dominic Chun-Ming; Zhu, Nianyong; Cheung, Kung‐Kai

doi:10.1016/j.ccr.2004.10.004

Cited by 159 publications

(79 citation statements)

References 88 publications

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“…[1][2][3][4][5] The effectiveness of a complex in a specific role is determined by its excited-state properties and can be manipulated through synthetic modifications. Early work in this field focused predominantly on tris-diimine ruthenium(II) complexes (e.g., [RuA C H T U N G T R E N N U N G (bpy) 3 ] 2 + ), but these materials offered limited color tuning capability due to thermal population of a nonemissive metal-centered ( 3 MC) state. [6] IridiumA C H T U N G T R E N N U N G (III) complexes, on the other hand, enable broader tuning possibilities due to their increased ligand-field stabilization energy (LFSE) and, as a consequence, less thermally accessible 3 MC states.…”

Section: Introductionmentioning

confidence: 99%

Synthetically Tailored Excited States: Phosphorescent, Cyclometalated Iridium(III) Complexes and Their Applications

Lowry

Bernhard

2006

Chemistry A European J

744

562

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Phosphorescent iridium(III) complexes are being widely explored for their utility in diverse photophysical applications. The performance of these materials in such roles depends heavily on their excited-state properties, which can be tuned through ligand and substituent effects. This concept article focuses on methods for synthetically tailoring the properties of bis-cyclometalated iridium(III) materials, and explores the factors governing the nature of their lowest excited state.

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Section: Introductionmentioning

confidence: 99%

Synthetically Tailored Excited States: Phosphorescent, Cyclometalated Iridium(III) Complexes and Their Applications

Lowry

Bernhard

2006

Chemistry A European J

744

562

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“…[6] Many achievements have also been seen in the area of bioanalysis with the labelling of proteins with electroactive (ferrocenyl complexes), [7][8][9][10][11] luminescent (rhenium(I) polypyridine and cyclometallated Ir III complexes) [12,13] and IRactive (metallocarbonyl complexes) [14,15] bioprobes. Another promising application for proteins that carry synthetic transition metal-organic complexes is as artificial metalloenzymes with unique catalytic properties.…”

Section: Introductionmentioning

confidence: 99%

Cysteine‐Specific, Covalent Anchoring of Transition Organometallic Complexes to the Protein Papain from Carica papaya

et al. 2007

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Site-directed and covalent introduction of various transition metal-organic entities to the active site of the cysteine endoproteinase, papain, was achieved by treatment of this enzyme with a series of organometallic maleimide derivatives specially designed for the purpose. Kinetic studies made it clear that time-dependent irreversible inactivation of papain occurred in the presence of these organometallic maleimides as a result of Michael addition of the sulfhydryl of Cys25. The rate and mechanism of inactivation were highly dependent on the structure of the organometallic entity attached to the maleimide group. Combined ESI-MS and IR analysis indicated that all the resulting papain adducts contained one organometallic moiety per protein molecule. This confirmed that chemospecific introduction of the metal complexes was indeed achieved. Thus, three novel reagents for heavy-atom derivatization of protein crystals, which include ruthenium, rhenium and tungsten, are now available for the introduction of electron-dense scatterers for phasing of X-ray crystallographic data.

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“…Gasser et al conjugated Re(I) tricarbonyl bisquinoline compound 30 with a Nuclear Localization Signal (NLS) sequence (31) and to a derivative of the Bombesin neuropeptide (32) (Figure 13) [73]. Bombesin is often used to selectively target cancer cells over healthy cells, since its receptor is overexpressed in some types of cancers.…”

Section: N-terminal Labelling Of Peptidementioning

confidence: 99%

“…This is generally done by tuning the structure of the N^N ligand, since it is involved in the MLCT. Two families of ligand have been particularly explored: (i) polypyridyl ligands, mostly derived from 2,2'-bipyridine (bpy) and 1,10-phenanthroline (phen) [19][20][21][23][24][25][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] and (ii) bis-quinoline and its derivatives, e.g. bis(phenanthridinylmethyl)amine (bpm) [22,[43][44][45].…”

Section: Spectroscopic Properties Of Luminescent Re(i) Tricarbonyl Comentioning

confidence: 99%

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Hostachy

Policar

Delsuc

2017

Coordination Chemistry Reviews

113

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Bio-imaging, by enabling the visualization of biomolecules of interest, has proved to be highly informative in the study of biological processes. Although fluorescence microscopy is probably one of the most used techniques, alternative methods of imaging, providing complementary information, are emerging. In this context, metal complexes represent valuable platforms for multimodal imaging, since they may combine interesting spectroscopic features and biologically relevant functionalization on a single molecular core. In particular, d6 low-spin rhenium tri-carbonyl complexes display unique luminescence and vibrational properties, and can be readily functionalized. Here we review their applications and potential as probes or drugs relying on their photophysical properties, before focusing on their use as multimodal probes for the labelling and imaging of peptides and proteins.

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Biological labelling reagents and probes derived from luminescent transition metal polypyridine complexes

Cited by 159 publications

References 88 publications

Synthetically Tailored Excited States: Phosphorescent, Cyclometalated Iridium(III) Complexes and Their Applications

Synthetically Tailored Excited States: Phosphorescent, Cyclometalated Iridium(III) Complexes and Their Applications

Cysteine‐Specific, Covalent Anchoring of Transition Organometallic Complexes to the Protein Papain from Carica papaya

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

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