Biological Living Cell in-Flow Detection Based on Microfluidic Chip and Compact Signal Processing Circuit

Quang, Loc Do; Bui, Tung Thanh; Hoang, Bao-Anh; Nhu, Cuong Nguyen; Thuy, Ha Tran Thi; Jen, Chun-Ping; Duc, Trinh Chu

doi:10.1109/tbcas.2020.3030017

Cited by 9 publications

(4 citation statements)

References 49 publications

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“…Early detection of diseases can enable treatment to the highest degree. Hence, in [ 58 ], a compact electronic module for counting the biological living cells was presented. This design helps in sensing the unbalanced impedance between the sensing microelectrodes.…”

Section: Biomedical Amplifiers and Various Designsmentioning

confidence: 99%

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Amplifiers in Biomedical Engineering: A Review from Application Perspectives

Kouhalvandi

Matekovits

Peter

2023

Sensors

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Continuous monitoring and treatment of various diseases with biomedical technologies and wearable electronics has become significantly important. The healthcare area is an important, evolving field that, among other things, requires electronic and micro-electromechanical technologies. Designed circuits and smart devices can lead to reduced hospitalization time and hospitals equipped with high-quality equipment. Some of these devices can also be implanted inside the body. Recently, various implanted electronic devices for monitoring and diagnosing diseases have been presented. These instruments require communication links through wireless technologies. In the transmitters of these devices, power amplifiers are the most important components and their performance plays important roles. This paper is devoted to collecting and providing a comprehensive review on the various designed implanted amplifiers for advanced biomedical applications. The reported amplifiers vary with respect to the class/type of amplifier, implemented CMOS technology, frequency band, output power, and the overall efficiency of the designs. The purpose of the authors is to provide a general view of the available solutions, and any researcher can obtain suitable circuit designs that can be selected for their problem by reading this survey.

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Section: Biomedical Amplifiers and Various Designsmentioning

confidence: 99%

“…This design helps in sensing the unbalanced impedance between the sensing microelectrodes. The general measurement setup is provided in [ 58 ], which includes the instrumentation amplifier stage for sensing the difference in signals and also a lock-in amplifier stage for demodulating the signals.…”

Section: Biomedical Amplifiers and Various Designsmentioning

confidence: 99%

Amplifiers in Biomedical Engineering: A Review from Application Perspectives

Kouhalvandi

Matekovits

Peter

2023

Sensors

View full text Add to dashboard Cite

show abstract

“…To avoid this problem LTS measurements are performed by employing the double ratio paradigm consisting in making two different measurements of the transmission coefficient by interchanging the sample and the reference holders in the two optical paths to cancel out any physical and optical differences between the two channels [19]. The intensities of the two transmitted laser beams are detected by two photodiodes whose generated voltage signals become the sample and reference input signals of an optoelectronic detection apparatus based on the phase-sensitive synchronous demodulation technique carried out by a Lock-In Amplifier (LIA) used to maximize the Signal-to-Noise Ratio (SNR) in presence of very noisy conditions [25]- [39]. However, the double ratio procedure propagates the measurement indetermination, increasing the associated final fractional uncertainty on the values of the particle size and concentration.…”

Section: Introductionmentioning

confidence: 99%

Laser Transmission Spectroscopy Based on Tunable-Gain Dual-Channel Dual-Phase LIA for Biological Nanoparticles Characterization

Sarra

Stanchieri

Marcellis

et al. 2021

IEEE Trans. Biomed. Circuits Syst.

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Size and absolute concentration of suspensions of nanoparticles are important information for the study and development of new materials and products in different industrial applications spanning from biotechnology and pharmaceutics to food preparation and conservation. Laser Transmission Spectroscopy (LTS) is the only methodology able to measure nanoparticle size and concentration by performing a single measurement. In this paper we report on a new variable gain calibration procedure for LTS-based instruments allowing to decrease of an order of magnitude the experimental indetermination of the particle size respect to the conventional LTS based on the double ratio technique. The variable gain calibration procedure makes use of a specifically designed tunable-gain, dual-channel, dual-phase Lock-In Amplifier (LIA) whose input voltage signals are those ones generated by two Si photodiodes that measure the laser beam intensities passing through the sample containing the nanoparticles and a reference optical path. The LTS variable gain calibration procedure has been validated by firstly using a suspension of NIST standard polystyrene nanoparticles even 36 hours after the calibration procedure was accomplished. The paper reports in detail the LIA implementation describing the design methodologies and the electronic circuits. As a case example of the characterization of biological nanostructures, we demonstrate that a single LTS measurement allowed to determine size density distribution of a population of extracellular vesicles extracted from orange juice (25 nm in size) with the presence of their aggregates having a size of 340 nm and a concentration smaller than 3 orders of magnitude.

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“…With the increasing demand for microfluidic technologies and their rapid development, emerging technologies in related fields increase the potential for microfluidic systems to achieve complex functions (Aleman et al, 2019;Jiang et al, 2014;Liao et al, 2018;MacDonald et al, 2003;Mach et al, 2002;Quang et al, 2020;Tsao et al, 2018;Zhu et al, 2019). Theoretical and applied researches on the quantification, diversification, and complexity of flow characteristics in microchannels have advanced, especially in the field of the specific functional flow of microfluidic recirculation.…”

Section: Introductionmentioning

confidence: 99%

A novel valve-less piezoelectric micropump generating recirculating flow

Chen

Gui

et al. 2021

Engineering Applications of Computational Fluid Mechanics

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Microfluidic devices or systems to generate recirculating flow are increasingly utilized in the fields of chemistry, biomedicine, biology, with bottlenecks in integration and miniaturization needed a breakthrough. Here, a concept for a highly integrated valve-less piezoelectric micropump generating recirculating flow (VPMGRF) is proposed, simultaneously realizing innovation in theory and method. Based on fluid inertiaand energy dissipation of vortexes, a novel double-loop tube was designed to achieve fluid flow in different directions along various paths, with the flow characteristics at different cross-sectional areas explored through computational fluid dynamics (CFD). Afterwards, as valve bodies, the double-loop tubes were connected with a piezoelectric-actuated chamber to constitute the VPMGRF, which was followed by establishing a theoretical model of the vibration, fluid dynamics, and net flow rate. Eventually, experimental results showed that VPMGRFs could generate internal recirculating flow and had a pump effect. The maximum net flow rate reached 5.19 mL/min at 8 Hz, corresponding to a vibrator amplitude of 35 μm and an output pressure amplitude of 4.27 kPa. Furthermore, the larger the characteristic length of the cross section, the greater the amplitude of the vibrators, the larger the amplitude of output pressure, and the slower the flow rate.

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Biological Living Cell in-Flow Detection Based on Microfluidic Chip and Compact Signal Processing Circuit

Cited by 9 publications

References 49 publications

Amplifiers in Biomedical Engineering: A Review from Application Perspectives

Amplifiers in Biomedical Engineering: A Review from Application Perspectives

Laser Transmission Spectroscopy Based on Tunable-Gain Dual-Channel Dual-Phase LIA for Biological Nanoparticles Characterization

A novel valve-less piezoelectric micropump generating recirculating flow

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