Biological properties of the intervertebral cages made of titanium containing a carbon-carbon composite covered with different polymers

Pešáková, V.; Smetana, Karel; Sochor, M.; Hulejová, Hana; Balik, K.

doi:10.1007/s10856-005-5933-7

Cited by 16 publications

(5 citation statements)

References 12 publications

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“…In this study we intended to tabularly demonstrate a main relation between surface characteristics and an early osteoblast response and the blood clot formation and thus to facilitate an orientation in a wide range of the implant materials already in a practical use. Besides Ti-based materials, materials not frequently used, such as CrCoMo alloy or the tested C/C composite (Pešáková et al 2005), were also included in to this study for better illustration of an effect of physicochemical parameters on the cell behavior. On behalf of better approaching to conditions in a real bone tissue, the human osteoblasts derived from a human connective tissue and from low passages were used for experiments.…”

Section: Discussionmentioning

confidence: 99%

The Interaction of Osteoblasts With Bone-Implant Materials: 1. The Effect of Physicochemical Surface Properties of Implant Materials

Kubies

Himmlová²,

Riedel³

et al. 2011

Physiol Res

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This comparative study of various surface treatments of commercially available implant materials is intended as guidance for orientation among particular surface treatment methods in term of the cell reaction of normal human osteoblasts and blood coagulation. The influence of physicochemical surface parameters such as roughness, surface free energy and wettability on the response of human osteoblasts in the immediate vicinity of implants and on the blood coagulation was studied. The osteoblast proliferation was monitored and the expression of tissue mediators (TNF-α, IL-8, MMP-1, bone alkaline phosphatase, VCAM-1, TGF-β) was evaluated after the cell cultivation onto a wide range of commercially available materials (titanium and Ti6Al4V alloy with various surface treatments, CrCoMo alloy, zirconium oxide ceramics, polyethylene and carbon/carbon composite). The formation of a blood clot was investigated on the samples immersed in a freshly drawn whole rabbit blood using scanning electron microscope. The surfaces with an increased osteoblast proliferation exhibited particularly higher surface roughness (here R a > 3.5 µm) followed by a high polar part of the surface free energy whereas the effect of wettability played a minor role. The surface roughness was also the main factor regulating the blood coagulation. The blood clot formation analysis showed a rapid coagulum formation on the rough titanium-based surfaces. The titanium with an etching treatment was considered as the most suitable candidate for healing into the bone tissue due to high osteoblast proliferation, the highest production of osteogenesis markers and low production of inflammatory cytokines and due to the most intensive blood clot formation.

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Section: Discussionmentioning

confidence: 99%

The Interaction of Osteoblasts With Bone-Implant Materials: 1. The Effect of Physicochemical Surface Properties of Implant Materials

Kubies

Himmlová²,

Riedel³

et al. 2011

Physiol Res

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“…The carbon bits were equivalent to foreign materials in the body that easily induce a postoperative immune response and the risk of organism infections[27]. Many bioactive coatings and films have been prepared to increase the biological activity of carbon materials and prevent the release of carbon particles and broken carbon fibers[6], such as poly (-2hydroxyethyl methacrylate) film[28] and carborundum coating[29], etc. Because of the biocompatibility, PDMS has been extensively studied in surgical implants, microfluidic devices and tissue engineering[30].…”

Section: Discussionmentioning

confidence: 99%

Ferulic acid and PDMS modified medical carbon materials for artificial joint prosthesis

Gao

Wang

et al. 2018

PLoS ONE

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Medical carbon material has been extensively studied due to their excellent biological and mechanical properties. However, the dissociation of the surface carbon particles greatly limited the application of medical carbon material (MCM). To overcome this defect, we introduced the polydimethylsiloxane, a polymer-coating material (PCM) that possesses acceptable biocompatibility, into medical carbon material to prevent the shedding of carbon debris. Additionally, to reduce inflammatory reactions and increase surface hydrophilicity, ferulic acid, also called Chinese medicine coating material (CCM), was used to modify the surface of polymer-coating material. We investigated the proliferation and adhesion of NIH-3T3 cells onto MCM, PCM and CCM in vitro. We showed that CCM exhibited excellent biological activity to promote cell growth. Twelve weeks after CCM implantation, bone defects were repaired, and the material showed acceptable chemical stability. The results indicated that the CCM composite possesses excellent mechanical property and favorable biocompatibility, which can be used for clinical bone repair.

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“…[12,13] One very attractive yet rather unexplored feature of glassy carbon is its excellent cytocompatibility, [14][15][16][17][18] which, in combination with its mechanical strength, [9] inertness, and patternability, [10] makes it a very suitable material for the fabrication of 3D cell culture platforms. …”

Section: D Carbon Scaffolds For Neural Stem Cell Culture and Magnetimentioning

confidence: 99%

“…Conversion of polymer structures into glassy carbon using pyrolysis is a widespread process that is extensively used for the fabrication of carbon MEMS and NEMS, [9,10] battery and supercapacitor anodes, [11] and carbon nanofibers. [12,13] One very attractive yet rather unexplored feature of glassy carbon is its excellent cytocompatibility, [14][15][16][17][18] which, in combination with its mechanical strength, [9] inertness, and patternability, [10] makes it a very suitable material for the fabrication of 3D cell culture platforms.…”

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confidence: 99%

3D Carbon Scaffolds for Neural Stem Cell Culture and Magnetic Resonance Imaging

Fuhrer

Bäcker

Kraft

et al. 2017

Adv Healthcare Materials

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3D Carbon Scaffolds for Neural Stem Cell Culture and Magnetic Resonance ImagingErwin Fuhrer, Anne Bäcker, Stephanie Kraft, Friederike J. Gruhl, Matthias Kirsch, Neil MacKinnon, Jan G. Korvink, and Swati Sharma* DOI: 10.1002/adhm.201700915 the dimensionality of the culture system. Many in vitro assays are 2D substrate systems, which raises the question of the relevance to tissues that thrive in a 3D environment. Since it has been recognized that the scaffold topology imparts important cues for cell development and function, there has been a concerted effort to develop 3D scaffold systems that better reproduce the in vivo environment.Common materials used for 3D scaffold fabrication for various cell differentiation, angiogenesis, and tumor growth studies include commercially available Matrigel, hydrogels, and cryogels. [2] Matrigel is a gelatinous protein mixture that contains components of the basement membrane, such as laminin, collagen type IV, and entactin. [3] Hydrogels (water-containing polymer networks) are composed of either natural polymers such as collagen, hyaluronates, fibrin, and chitosan or synthetic polymers such as polyvinyl caprolactam and polyethylene glycol. [4] These materials are generally advantageous since a 3D hydrated network can be produced together with the desired chemical cues required for cell development (e.g., growth factors and cell adhesion promoters). In addition, the porous structure (size and shape) of the polymer network can be tuned by varying the freezing conditions and concentration of the cross-linker in the case of cryogels. [5,6] However, several disadvantages can be identified. Matrigel is often poorly chemically defined and thus culture-to-culture variation has been observed. [7] Hydrogels may require further chemical processing to introduce the important cellular chemical cues. [8] This introduces the potential for residual chemicals to be entrapped within the gel, influencing the reproducibility of cell development. These materials additionally have the potential to degrade after prolonged exposure to culture media. While not always an issue, in cases of extended culture times, cell cultures require a scaffold that will maintain its mechanical integrity. In this work, we propose glassy carbon as a material capable of overcoming these challenges.Conversion of polymer structures into glassy carbon using pyrolysis is a widespread process that is extensively used for the fabrication of carbon MEMS and NEMS, [9,10] battery and supercapacitor anodes, [11] and carbon nanofibers. [12,13] One very attractive yet rather unexplored feature of glassy carbon is its excellent cytocompatibility, [14][15][16][17][18] which, in combination with its mechanical strength, [9] inertness, and patternability, [10] makes it a very suitable material for the fabrication of 3D cell culture platforms.

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Biological properties of the intervertebral cages made of titanium containing a carbon-carbon composite covered with different polymers

Cited by 16 publications

References 12 publications

The Interaction of Osteoblasts With Bone-Implant Materials: 1. The Effect of Physicochemical Surface Properties of Implant Materials

The Interaction of Osteoblasts With Bone-Implant Materials: 1. The Effect of Physicochemical Surface Properties of Implant Materials

Ferulic acid and PDMS modified medical carbon materials for artificial joint prosthesis

3D Carbon Scaffolds for Neural Stem Cell Culture and Magnetic Resonance Imaging

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