Biomarker evaluation as a potential cause of gender differences in obesity paradox among patients with STEMI

Baumann, Stefan; Koepp, Johanna; Becher, Tobias; Huseynov, Aydin; Bosch, Katharina; Behnes, Michael; Fastner, Christian; El‐Battrawy, Ibrahim; Renker, Matthias; Lang, Siegfried; Weiß, Christel; Borggrefe, Martin; Lehmann, Ralf; Akın, İbrahim

doi:10.1016/j.carrev.2015.12.012

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…Previous studies have shown that PD is often positively related with obesity or diabetes [48,49]. The aforementioned risk factors are often used as index factors to determine body fat content and cardiovascular disease, and their changes in PD are similar to those observed in patients with obesity and diabetes [50,51]. An environment with high blood lipids and glucose is the most important cause of inflammatory responses in the body [52], which may trigger the expression of relevant factors such as IL-6, IL-10 and TNF-α, thereby increasing the risk of periodontal inflammation [53].…”

Section: Discussionmentioning

confidence: 99%

A allele of ICAM-1 rs5498 and VCAM-1 rs3181092 is correlated with increased risk for periodontal disease

Sun

Zhang

2019

Open Life Sciences

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ObjectivePeriodontal disease (PD) is viewed today as multifactorial problems initiated and sustained by bacteria but significantly modified by the body’s response to bacterial plaque. Recent studies have suggested that gene polymorphisms could be involved in the pathophysiology of periodontitis. This study aimed to investigate a possible correlation of the polymorphisms of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) with PD.MethodsThe genotypes of ICAM-1 and VCAM-1 were initially determined in PD patients using denaturing high performance liquid chromatography (DHPLC). ELISA was then conducted to measure ICAM-1 and VCAM-1 protein levels. Next, the association of ICAM-1/VCAM-1 genotype distribution and expression with clinical indicators and severity of PD was analyzed.ResultsPD patients contained increased levels of hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL), increased ICAM-1 and VCAM-1 protein levels, and decreased high-density lipoprotein (HDL) level. The GG genotype and G allele at ICAM-1 rs5498, as well as the AG and GG genotypes and G allele at VCAM-1 rs3181092 may reduce PD risk.ConclusionTo sum up, the overexpressed ICAM-1 and VCA M-1 as well as A allele of ICAM-1 rs5498 and VCAM-1 rs3181092 is associated with the onset of PD.

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Section: Discussionmentioning

confidence: 99%

A allele of ICAM-1 rs5498 and VCAM-1 rs3181092 is correlated with increased risk for periodontal disease

Sun

Zhang

2019

Open Life Sciences

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“…However, the causes and mechanisms of the obesity paradox remain unclear. Kang et al (2010), Timóteo et al (2011, Baumann et al (2016), Champagne‐Langabeer et al (2017), Witassek et al (2014) and Shabbar et al (2021) indicate that patients with high BMI were younger at the time of STEMI, which may have a beneficial impact on their prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…We excluded 148 articles after reviewing their titles and abstracts and 26 articles after reading the full text, including 18 articles irrelevant to our topic, three articles not found, and five articles of the conference. Finally, 12 (Baumann et al, 2016;Champagne-Langabeer et al, 2017;Iakobishvili et al, 2006;Joyce et al, 2017;Kang et al, 2010;Kosuge et al, 2008;Lazzeri et al, 2013;Moscarella et al, 2017;Shabbar et al, 2021;Timoteo et al, 2011;Witassek et al, 2014;Wu et al, 2017) articles met the standards and were included in this meta-analysis (Figure 1). A total of 54,397 patients were included in this meta-analysis.…”

Section: Basic Information Of the Included Studiesmentioning

confidence: 99%

The obesity paradox in ST‐segment elevation myocardial infarction patients: A meta‐analysis

Liu

Lin

Han

et al. 2022

Noninvasive Electrocardiol

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“…Initial BMI values were calculated as the weight in kilograms divided by the height in meters squared. Consistent with previous literature on obesity, 11–14 each patient was grouped into one of six BMI groups according to World Health Organization (WHO) categories: underweight (BMI<18.5), normal weight (BMI 18.5 to 25), overweight (BMI 25 to 30), obese I (BMI 30 to 35), obese II (BMI 35 to 40) and obese III (BMI>40). The primary outcome of interest, RBC transfusion, was defined as the administration of one or more RBC units at any time during the intraoperative period.…”

Section: Discussionmentioning

confidence: 99%

A BMI >35 does not protect patients undergoing cardiac bypass surgery from red blood cell transfusion

Mongero¹,

Tesdahl²,

Stammers³

et al. 2016

Perfusion

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The effect of obesity on allogeneic intraoperative blood product transfusion in patients undergoing coronary artery bypass graft surgery (CABG) is poorly understood. We analyzed the influence of obesity on the risk of intraoperative red blood cell (RBC) transfusion among 45,200 consecutive non-reoperative CABG procedures from a multi-institutional perfusion database. A body mass index (BMI) in obese I category was associated with a 9.9% decrease in transfusion risk (p<0.05). Compared to patients with a normal BMI, obese I and obese III patients do not have any change in the relative risk of RBC transfusion. Overweight and mild obesity have a protective role in reducing intraoperative blood transfusion during cardiopulmonary bypass (CPB) surgery. However, logistic regression analysis showed that much of the observed reduction in transfusion rates for obese patients can be accounted for by other known confounds. The lack of a linear effect of increasing BMI on blood transfusion risk is a novel finding and warrants further investigation.

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Biomarker evaluation as a potential cause of gender differences in obesity paradox among patients with STEMI

Cited by 7 publications

References 28 publications

A allele of ICAM-1 rs5498 and VCAM-1 rs3181092 is correlated with increased risk for periodontal disease

A allele of ICAM-1 rs5498 and VCAM-1 rs3181092 is correlated with increased risk for periodontal disease

The obesity paradox in ST‐segment elevation myocardial infarction patients: A meta‐analysis

A BMI >35 does not protect patients undergoing cardiac bypass surgery from red blood cell transfusion

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