Biomarkers of Oxidative Stress in Blood

Alzaïd, Fawaz; Patel, Vinood B.; Preedy, Victor R.

doi:10.1007/978-94-007-7696-8_41

Cited by 4 publications

(5 citation statements)

References 101 publications

(156 reference statements)

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“…As a consequence, the prosthetic group FADH 2 appears erroneously as the substrate of CII in the ETS linked to succinate oxidation. This error is widely propagated in publications found from 2001 to 2023 ( 4 , 23 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 …”

Section: The Fadh 2 - Fad Confusion In the Succina...mentioning

confidence: 99%

“… CII e-input errors Ref. NADH → NAD + + H + ( 45 , 97 , 99 ) FADH 2 → FAD ( 4 , 23 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , ...…”

Section: The Fadh 2 - Fad Confusion In the Succina...unclassified

“…FADH 2 is depicted as (1) product and (2) substrate of Complex II by ( A ) ( 4 ), ( B ) ( 80 ), as in ref. ( 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 104 , 192 , 193 , 194 , 199 , 201 , 202 , 203 , 204 ,…”

Section: The Fadh 2 - Fad Confusion In the Succina...mentioning

confidence: 99%

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Complex II ambiguities—FADH2 in the electron transfer system

Gnaiger

2024

Journal of Biological Chemistry

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Section: The Fadh 2 - Fad Confusion In the Succina...mentioning

confidence: 99%

Section: The Fadh 2 - Fad Confusion In the Succina...unclassified

Section: The Fadh 2 - Fad Confusion In the Succina...mentioning

confidence: 99%

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Complex II ambiguities—FADH2 in the electron transfer system

Gnaiger

2024

Journal of Biological Chemistry

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“…Oxidative stress-induced changes in other tissues are well described, considering that the loss of balance between the generation of ROS and antioxidant capacity is a characteristic of many pathological processes [ 32 ]. In recent years, studies have proved the involvement of oxidative stress in different pathologies, like cardiovascular, kidney, neurodegenerative, pulmonary, and malignant diseases, as well as in the process of aging [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review

Ungureanu,

Grădinaru,

Ghiciuc

et al. 2023

Medicina

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Background and Objectives: Oxidative stress is involved in the alterations at the level of salivary glands, being the cause of oral pathologies like xerostomia, periodontitis, gingivitis, leucoplakia, and cancer. It is known that antioxidants can reverse changes induced by drugs or other chemicals in some organs, but the question is whether these substances can reduce or revert the effects of oxidative stress at the salivary gland level. Our aim was to find histopathological data at the level of salivary glands supporting the hypothesis of the reversal of oxidative stress-induced changes after the treatment with substances with antioxidant effect. Materials and Methods: A systematic search was conducted in PubMed, Science Direct, and Springer databases, including research articles on oxidative stress histological aspects and oxidative stress biomarkers induced by drugs or other chemicals on salivary glands. Results: Out of 1756 articles, 25 articles were selected with data on tissue homogenate used for biochemical analysis of oxidative and antioxidative markers, along with routine hematoxylin eosin (HE) and immunohistochemical analysis used for histopathological and immunohistochemical diagnosis. Drugs (antineoplastic drugs, antibiotics, and analgesics), alcohol, heavy metals, and fluoride can cause oxidative stress, resulting in morphological changes in different tissues, including in salivary glands. There are many antioxidants but only a few were evaluated regarding the effects on salivary glands in animal studies, such as hesperidin and selenium, which can reverse the damage induced by cyclophosphamide; 10-dehydrogingerdione (10-DHGD), a compound extracted from ginger, which has a protective effect against the oxidative stress and apoptosis induced by tramadol; and glycyrrhizic acid, which may repair the injuries incurred after the administration of sodium nitrite. Conclusions: Substances such as hesperidin, selenium, 10-dehydrogingerdione, and glycyrrhizic acid are antioxidants with proven restorative effects on salivary glands for the damage induced by oxidative stress after exposure to drugs and other chemical substances; however, demonstrating their similar effects in human salivary glands is challenging.

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“…6Bii). Next, following surface modification with RBC-Ms, MOF Hb /M-NPs displayed a similar tendency and slightly enhanced O2 •scavenging activity as compared to MOF Hb /PDA-NPs, could be attributed to the consumption of O2 •for oxidization of proteins embedded within the RBC-Ms. 54 Since the depletion of O2 •results in the production of H2O2, which is another harmful ROS, we next evaluated the NPs ability to decompose H2O2 into non-toxic oxygen and water. To do so, we employed the Amplex Red assay where H2O2 acts as a co-substrate for its oxidation into fluorescent resorufin in the presence of HRP (Fig.…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 99%