Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

Han, Xianbo; Alu, Aqu; Li, Hongmei; Shi, Yi; Wei, Xiawei; Cai, Lulu; Wei, Yuquan

doi:10.1016/j.bioactmat.2022.01.011

Cited by 80 publications

(52 citation statements)

References 234 publications

(287 reference statements)

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“…Different materials can be used as the base, vehicle or matrix for the development of controlled DDS. BC is a viable option for this purpose and has been used as a topical agent for the encapsulation and delivery of different types of active compounds, including insoluble drugs [ 176 , 178 ]. Recent advances in the use of BC for controlled DDS include oral, ocular, intratumor, topical and transdermal delivery.…”

Section: Bacterial Cellulosementioning

confidence: 99%

Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

et al. 2022

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Chronic ulcers are among the main causes of morbidity and mortality due to the high probability of infection and sepsis and therefore exert a significant impact on public health resources. Numerous types of dressings are used for the treatment of skin ulcers-each with different advantages and disadvantages. Bacterial cellulose (BC) has received enormous interest in the cosmetic, pharmaceutical, and medical fields due to its biological, physical, and mechanical characteristics, which enable the creation of polymer composites and blends with broad applications. In the medical field, BC was at first used in wound dressings, tissue regeneration, and artificial blood vessels. This material is suitable for treating various skin diseases due its considerable fluid retention and medication loading properties. BC membranes are used as a temporary dressing for skin treatments due to their excellent fit to the body, reduction in pain, and acceleration of epithelial regeneration. BC-based composites and blends have been evaluated and synthesized both in vitro and in vivo to create an ideal microenvironment for wound healing. This review describes different methods of producing and handling BC for use in the medical field and highlights the qualities of BC in detail with emphasis on biomedical reports that demonstrate its utility. Moreover, it gives an account of biomedical applications, especially for tissue engineering and wound dressing materials reported until date. This review also includes patents of BC applied as a wound dressing material.

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Section: Bacterial Cellulosementioning

confidence: 99%

Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

et al. 2022

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“…On the contrary, the genes implicated in late AMD have been extensively studied. Main genetic variants identified are in ABCA4, variations in the apolipoprotein E (APOE) gene were also reported, GWAS, a common variant (rs1061170, p.Y402H) in the complement factor H (CFH), ARMS2/HTRA1 locus on chromosome 10 (10q26) [ 56 , 57 , 58 , 59 , 60 ].…”

Section: Biological Therapies For the Treatment Of Amdmentioning

confidence: 99%

Therapeutic Approaches for Age-Related Macular Degeneration

Galindo

Blanco-Llamero

Ana

et al. 2022

IJMS

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Damage to the retinal pigment epithelium, Bruch’s membrane and/or tissues underlying macula is known to increase the risk of age-related macular degeneration (AMD). AMD is commonly categorized in two distinct types, namely, the nonexudative (dry form) and the exudative (wet form). Currently, there is no ideal treatment available for AMD. Recommended standard treatments are based on the use of vascular endothelial growth factor (VEGF), with the disadvantage of requiring repeated intravitreal injections which hinder patient’s compliance to the therapy. In recent years, several synthetic and natural active compounds have been proposed as innovative therapeutic strategies against this disease. There is a growing interest in the development of formulations based on nanotechnology because of its important role in the management of posterior eye segment disorders, without the use of intravitreal injections, and furthermore, with the potential to prolong drug release and thus reduce adverse effects. In the same way, 3D bioprinting constitutes an alternative to regeneration therapies for the human retina to restore its functions. The application of 3D bioprinting may change the current and future perspectives of the treatment of patients with AMD, especially those who do not respond to conventional treatment. To monitor the progress of AMD treatment and disease, retinal images are used. In this work, we revised the recent challenges encountered in the treatment of different forms of AMD, innovative nanoformulations, 3D bioprinting, and techniques to monitor the progress.

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“…However, direct contact with the wound environment or the shear force during injection might hinder the survival and the following function of stem cells. Meanwhile, functional molecules secreted from ASCs cannot be released or transported to the adjacent tissue stably and continuously, which might necessitate repeated treatment ( Abdullahi et al, 2016 ; Han et al, 2022 ). As an alternative approach, encapsulation of ASCs into hydrogels and local application offers a considerable potential choice.…”

Section: Introductionmentioning

confidence: 99%

Direct three-dimensional printed egg white hydrogel wound dressing promotes wound healing with hitching adipose stem cells

Wang

Niu

et al. 2022

Front. Bioeng. Biotechnol.

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Current wound dressing based on hydrogel offers a promising way to accelerate the healing process, yet great challenges remain in the development of a highly integrated and efficient platform with the combination of therapeutic biomolecules and stem cells. Herein, a natural hydrogel wound dressing from egg white can be conveniently obtained by feasible physical crosslinking, the prepared hydrogel dressing features interconnected microporous channels, direct 3D printing, cytocompatibility, and intrinsic biomolecules to advance cell behavior. The 3D printed egg white hydrogels promote the adhesion and proliferation of adipose-derived stem cells (ASCs) without obvious cytotoxicity. In addition, this integrated hydrogel platform accompanied with adipose-derived stem cells accelerates wound healing through the enhancement of fibroblast proliferation, angiogenesis, and collagen rearrangement in the wound bed. The egg white hydrogel provides an effective wound caring product possessing low cost, easy availability along with ready manufacturing, and advanced therapeutic effect, which may be extended for the management of chronic or other complicated wounds.

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Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

Cited by 80 publications

References 234 publications

Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

Therapeutic Approaches for Age-Related Macular Degeneration

Direct three-dimensional printed egg white hydrogel wound dressing promotes wound healing with hitching adipose stem cells

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