Biomaterials and Scaffolds in Bone and Musculoskeletal Engineering

Kosuge, Dennis; Khan, Wasim; Haddad, Behrooz; Marsh, David

doi:10.2174/1574888x11308030002

Cited by 30 publications

(23 citation statements)

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“…Their disadvantages are quick loss of mechanical properties after implantation and potential toxicity. Synthetic materials also show a lower degree of biocompatibility, than the natural ones (Kosuge et al, ). Most commonly used synthetic polymers in AC regeneration include, poly(ethylene glycol) (PEG) and its derivatives, poly(Lactide‐co‐glycolide) (PLGA), and poly( l ‐lactic acid) (PLLA).…”

Section: Advanced Therapiesmentioning

confidence: 99%

Management of knee osteoarthritis. Current status and future trends

Ondrésik

Maia

Morais

et al. 2016

Biotech & Bioengineering

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Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2017;114: 717-739. © 2016 Wiley Periodicals, Inc.

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Section: Advanced Therapiesmentioning

confidence: 99%

Management of knee osteoarthritis. Current status and future trends

Ondrésik

Maia

Morais

et al. 2016

Biotech & Bioengineering

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“…Generally speaking, the degradation time of materials should match the production speed of the new tissue. Rapid degradation of the scaffold affects the adhesion of chondrocytes, while slow degradation hinders cells' proliferation and matrix secretion (Bettinger, 2011;Kosuge et al, 2013). From H & E staining and immunohistochemical staining results, we observed that chondrocytes cultured in hydrogel in vitro can grow and secrete extracellular matrix-collagen II.…”

Section: Discussionmentioning

confidence: 93%

Repair of articular cartilage defects in rabbits through tissue-engineered cartilage constructed with chitosan hydrogel and chondrocytes

Zhao

Chen

Liu

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Objective: In our previous work, we prepared a type of chitosan hydrogel with excellent biocompatibility. In this study, tissue-engineered cartilage constructed with this chitosan hydrogel and costal chondrocytes was used to repair the articular cartilage defects. Methods: Chitosan hydrogels were prepared with a crosslinker formed by combining 1,6-diisocyanatohexane and polyethylene glycol. Chitosan hydrogel scaffold was seeded with rabbit chondrocytes that had been cultured for one week in vitro to form the preliminary tissue-engineered cartilage. This preliminary tissue-engineered cartilage was then transplanted into the defective rabbit articular cartilage. There were three treatment groups: the experimental group received preliminary tissue-engineered cartilage; the blank group received pure chitosan hydrogels; and, the control group had received no implantation. The knee joints were harvested at predetermined time. The repaired cartilage was analyzed through gross morphology, histologically and immunohistochemically. The repairs were scored according to the international cartilage repair society (ICRS) standard. Results: The gross morphology results suggested that the defects were repaired completely in the experimental group after twelve weeks. The regenerated tissue connected closely with subchondral bone and the boundary with normal tissue was fuzzy. The cartilage lacuna in the regenerated tissue was similar to normal cartilage lacuna. The results of ICRS gross and histological grading showed that there were significant differences among the three groups (P<0.05). Conclusions: Chondrocytes implanted in the scaffold can adhere, proliferate, and secrete extracellular matrix. The novel tissue-engineered cartilage constructed in our research can completely repair the structure of damaged articular cartilage.

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“…Bone tissue engineering has been developing as a promising approach to regenerate bone defects where it can be implanted in vivo at the bone defect site, and a precise design of 3D scaffold is essential to effectively support and promote new bone tissue regeneration . Previously, we have shown that the physical and mechanical properties of methacrylated HA‐based hydrogels could be optimized through types and concentration of the chemical crosslinkers .…”

Section: Discussionmentioning

confidence: 99%

Enhanced Bone Defect Repair by Polymeric Substitute Fillers of MultiArm Polyethylene Glycol‐Crosslinked Hyaluronic Acid Hydrogels

Yuan

Maturavongsadit

Metavarayuth

et al. 2019

Macromolecular Bioscience

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Bone regeneration is still one of the greatest challenges for the treatment of bone defects since no current clinical approach has been proven effective. To develop an alternative biodegradable bone graft material, multiarm polyethylene glycol (PEG) crosslinked hyaluronic acid (HA) hydrogels are synthesized and applied to promote osteogenesis of mesenchymal stem cells (MSCs) with the ultimate goal for bone defect repair. The multiarm PEG‐HA hydrogels provide a significant improvement of alkaline phosphatase (ALP) activity and calcium mineralization of the in vitro encapsulated MSCs under osteogenic condition after 3, 7, and 28 days. In addition, the multiarm PEG‐HA hydrogels also facilitate healing of the cranial bone defects more effectively in a Sprague Dawley rat model after 10 weeks of implantation based on histological evaluations and microcomputed tomography analysis. These promising results set the stage for the development of innovative biodegradable hydrogels to provide a more effective and versatile treatment option for bone regeneration.

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Biomaterials and Scaffolds in Bone and Musculoskeletal Engineering

Cited by 30 publications

References 0 publications

Management of knee osteoarthritis. Current status and future trends

Management of knee osteoarthritis. Current status and future trends

Repair of articular cartilage defects in rabbits through tissue-engineered cartilage constructed with chitosan hydrogel and chondrocytes

Enhanced Bone Defect Repair by Polymeric Substitute Fillers of MultiArm Polyethylene Glycol‐Crosslinked Hyaluronic Acid Hydrogels

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