Biomechanical evaluation of porous biodegradable scaffolds for revision knee arthroplasty

Terrier, Alexandre; Sedighi-Gilani, Marjan; Ghias, Alireza Roshan; Aschwanden, Line; Pioletti, Dominique P.

doi:10.1080/10255840802603589

Cited by 10 publications

(9 citation statements)

References 23 publications

(28 reference statements)

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“…As already mentioned, calcium phosphate scaffolds cannot sustain shock due to their brittle nature, rendering their use difficult in, for example, filling bone defects during total knee revision. For this particular application, based on a numerical study, we determined that the biocomposite could sustain a 1% deformation [11], due to its ductile behavior. This 1% deformation was recently demonstrated to increase bone formation during an in vivo study performed in rats [30].…”

Section: Discussionmentioning

confidence: 99%

“…New bone formation was mainly seen at the border of the defect and newly formed bone was much denser than the trabecular structure surrounding the defect. then provide more certainty that the bone would have enough time to colonize the biocomposite, achieving the mechanical properties required to sustain the load [11].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, a biocomposite of controlled porosity combining b-tricalcium phosphate (b-TCP) and poly(L-lactic acid) (PLA) was obtained by supercritical gas foaming [9]. This biocomposite displayed a cellular microstructure and elastic properties close to human trabecular bone [10] and was shown in a numerical study to be able to sustain the load if used as a tibial spacer to fill the bone defect during revision of total knee replacement [11]. In vivo studies in small animals have demonstrated the biocompatibility and osteoconductivity of the biocomposite developed [12].…”

Section: Introductionmentioning

confidence: 99%

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Augmentation of bone defect healing using a new biocomposite scaffold: An in vivo study in sheep

et al. 2010

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a b s t r a c tPrevious studies support resorbable biocomposites made of poly(L-lactic acid) (PLA) and b-tricalcium phosphate (TCP) produced by supercritical gas foaming as a suitable scaffold for tissue engineering. The present study was undertaken to demonstrate the biocompatibility and osteoconductive properties of such a scaffold in a large animal cancellous bone model. The biocomposite (PLA/TCP) was compared with a currently used b-TCP bone substitute (ChronOS™, Dr. Robert Mathys Foundation), representing a positive control, and empty defects, representing a negative control. Ten defects were created in sheep cancellous bone, three in the distal femur and two in the proximal tibia of each hind limb, with diameters of 5 mm and depths of 15 mm. New bone in-growth (osteoconductivity) and biocompatibility were evaluated using microcomputed tomography and histology at 2, 4 and 12 months after surgery. The in vivo study was validated by the positive control (good bone formation with ChronOS™) and the negative control (no healing with the empty defect). A major finding of this study was incorporation of the biocomposite in bone after 12 months. Bone in-growth was observed in the biocomposite scaffold, including its central part. Despite initial fibrous tissue formation observed at 2 and 4 months, but not at 12 months, this initial fibrous tissue does not preclude long-term application of the biocomposite, as demonstrated by its osteointegration after 12 months, as well as the absence of chronic or long-term inflammation at this time point.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Augmentation of bone defect healing using a new biocomposite scaffold: An in vivo study in sheep

et al. 2010

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“…Computational analysis could also be used to evaluate the mechanical properties of custom-made scaffolds and verify that targeted values are obtained (Williams et al 2005). For an application in revision knee arthroplasty, Terrier et al (2009) evaluated the impact of scaffold size on primary stability when used to fill bone defects in the tibial plateau. A more specific application lies in a proposed patient-based approach for replacing vertebral bodies with the help of computational methods as central tools using building blocks for the biomechanical evaluation of the developed scaffold (Wettergreen et al 2005).…”

Section: Computer Methods For Bone Tissue Engineering Mechanicsmentioning

confidence: 99%

Biomechanics in bone tissue engineering

Pioletti

2010

Computer Methods in Biomechanics and Biomedical Engineering

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Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach; so are aspects of interface micromotion, bone ingrowths inside the scaffold and finally, the mechanical integrity of the scaffold during its degradation. A proposed view is presented herein on how biomechanical aspects can be synthesised and where future developments are needed. In particular, a distinction is made between the mechanical and the mechanotransductional aspects of bone tissue engineering: the former could be related to osteoconduction, while the latter may be correlated to the osteoinductive properties of the scaffold. This distinction allows biomechanicians to follow a strategy in the development of a scaffold having not only mechanical targets but also incorporating some mechanotransduction principles.

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“…Metallic augments do not restore bone stock and their integration with adjacent bone can be an issue (Huff and Sculco 2007;Mabry and Hanssen 2007). Thus, bone scaffold has been proposed as an alternative which could restore the bone function (Terrier et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Translation of Biomechanical Concepts in Bone Tissue Engineering: From Animal Study to Revision Knee Arthroplasty

Ghias¹,

Terrier²,

Jolles-Haeberli³

et al. 2012

Journal of Biomechanics

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Bone defects in revision knee arthroplasty are often located in load-bearing regions. The goal of this study was to determine whether a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to answer this question, we proposed a novel translation procedure having four steps: (1) determining the mechanical stimulus using finite element method, (2) designing an animal study to measure bone formation spatially and temporally using micro-CT imaging in the scaffold subjected to the estimated mechanical stimulus, (3) identifying bone formation parameters for the loaded and non-loaded cases appearing in a recently developed mathematical model for bone formation in the scaffold and (4) estimating the stiffness and the bone formation in the bone-scaffold construct. With this procedure, we estimated that after 3 years mechanical stimulation increases the bone volume fraction and the stiffness of scaffold by 1.5-and 2.7-fold, respectively, compared to a non-loaded situation.

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Biomechanical evaluation of porous biodegradable scaffolds for revision knee arthroplasty

Cited by 10 publications

References 23 publications

Augmentation of bone defect healing using a new biocomposite scaffold: An in vivo study in sheep

Augmentation of bone defect healing using a new biocomposite scaffold: An in vivo study in sheep

Biomechanics in bone tissue engineering

Translation of Biomechanical Concepts in Bone Tissue Engineering: From Animal Study to Revision Knee Arthroplasty

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