Biomedical Application of Electroactive Polymers in Electrochemical Sensors: A Review

Runsewe, Damilola; Betancourt, Tania; Irvin, Jennifer A.

doi:10.3390/ma12162629

Cited by 38 publications

(25 citation statements)

References 121 publications

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“…Conducting polymers, such as polyacetylene, polypyrrole, polythiophene, polyaniline and their derivatives have received considerable attention for their unique metal and semiconductor-like properties compared with traditional polymers [ 208 ]. Due to their favorable mechanical, optical, electrical, and electrochemical characteristics, CPs have been widely used to fabricate sensors, biomedical and microfluidic devices, etc.…”

Section: Electrochemical Sensor For Water Contaminantsmentioning

confidence: 99%

A Review of Nanocomposite-Modified Electrochemical Sensors for Water Quality Monitoring

Kanoun

Lazarević‐Pašti

Pašti

et al. 2021

Sensors

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Electrochemical sensors play a significant role in detecting chemical ions, molecules, and pathogens in water and other applications. These sensors are sensitive, portable, fast, inexpensive, and suitable for online and in-situ measurements compared to other methods. They can provide the detection for any compound that can undergo certain transformations within a potential window. It enables applications in multiple ion detection, mainly since these sensors are primarily non-specific. In this paper, we provide a survey of electrochemical sensors for the detection of water contaminants, i.e., pesticides, nitrate, nitrite, phosphorus, water hardeners, disinfectant, and other emergent contaminants (phenol, estrogen, gallic acid etc.). We focus on the influence of surface modification of the working electrodes by carbon nanomaterials, metallic nanostructures, imprinted polymers and evaluate the corresponding sensing performance. Especially for pesticides, which are challenging and need special care, we highlight biosensors, such as enzymatic sensors, immunobiosensor, aptasensors, and biomimetic sensors. We discuss the sensors’ overall performance, especially concerning real-sample performance and the capability for actual field application.

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Section: Electrochemical Sensor For Water Contaminantsmentioning

confidence: 99%

A Review of Nanocomposite-Modified Electrochemical Sensors for Water Quality Monitoring

Kanoun

Lazarević‐Pašti

Pašti

et al. 2021

Sensors

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“…The detection of malondialdehyde, one of common biomarkers of oxidative stress, was achieved at a lower limit of quantification (0.329 nM). This was possible since polyarginine-graphene QDs accelerate the rate of electron transfer of malondialdehyde and have a good electroactivity (Runsewe et al, 2019) for redox reaction of the biomarker, enhancing its detection sensitivity (Hasanzadeh et al, 2017). Carbon QDs were embedded in a ZrHf metal-organic framework (ZrHf-MOF) which shows strong fluorescence and enhanced amino-functionalization.…”

Section: Quantum Dotsmentioning

confidence: 99%

Current nanotechnology advances in diagnostic biosensors

et al. 2020

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Rapid, reliable and easy access diagnostics can significantly improve early detection and treatment monitoring of high mortality diseases, such as cardiovascular diseases, cancer, diabetes, among others (Rebelo et al., 2019). The successfully diagnostics of a disease, even prior to the manifestation of any symptom, can be crucial to efficacious treatment and survival rate (Chamorro-Garcia & Merkoçi, 2016).Biomarkers are frequently used to diagnose these diseases; however, they need to be quantified in a specific concentration range in physiological fluids, such as blood and urine, which is a time-consuming process that uses bulky and expensive laboratory equipment.Thus, there is a need for portable, rapid and reliable technologies that can simplify laboratory biomarker quantitation (Wu et al., 2017). In order to achieve this, a plethora of sensing mechanisms have been combined with biological elements, producing biosensor technologies, which enable the quantitation of analytes in mixtures.

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“…Conducting polymers have received great attention for electrochemical applications because the π-bond delocalized electrons on the conjugated structures lead to excellent electrical and conductive properties [ 18 , 19 ]. The common conducting polymers for electrochemical biosensors are polyaniline (PANi) [ 20 ], polypyrrole (PPy) [ 21 ], poly(3,4-ethylenedioxythiophene) (PEDOT) [ 22 ] and polythiophene (PTH) [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

2021

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Dopamine (DA) is an important neurotransmitter which indicates the risk of several neurological diseases. The selective determination with low detection limit is necessary for early diagnosis and prevention of neurological diseases associated with abnormal concentration of DA. The purpose of this study is to fabricate a poly(3-aminobenzylamine)/poly(sodium 4-styrenesulfonate) (PABA/PSS) multilayer thin film for use as an electrochemical DA biosensor. The PABA was firstly synthesized using a chemical oxidation method of 3-aminobenzylamine (ABA) monomer with ammonium persulfate (APS) as an oxidant. For electrochemical biosensor, the PABA/PSS thin film was fabricated on fluorine doped tin oxide (FTO)-coated glass substrate using the layer-by-layer (LBL) self-assembly method. The optimized number of bilayers was achieved using SEM and cyclic voltammetry (CV) results. The electroactivity of the optimized LBL thin film toward detection of DA in neutral solution was studied by CV and amperometry. The PABA/PSS thin film showed good sensitivity for DA sensing with sensitivity of 6.922 nA.cm−2.µM−1 and linear range of 0.1–1.0 µM (R2 = 0.9934), with low detection limit of 0.0628 µM, long-term stability and good reproducibility. In addition, the selectivity of the PABA/PSS thin film for detection of DA under the common interferences (i.e., ascorbic acid, uric acid and glucose) was also presented. The prepared PABA/PSS thin film showed the powerful efficiency for future use as DA biosensor in real sample analysis.

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Biomedical Application of Electroactive Polymers in Electrochemical Sensors: A Review

Cited by 38 publications

References 121 publications

A Review of Nanocomposite-Modified Electrochemical Sensors for Water Quality Monitoring

A Review of Nanocomposite-Modified Electrochemical Sensors for Water Quality Monitoring

Current nanotechnology advances in diagnostic biosensors

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

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