Biomedical coatings by the covalent immobilization of polysaccharides onto gas-plasma-activated polymer surfaces

Dai, Liming; StJohn, Heather A. W.; Bi, Jing; Zientek, Paul; Chatelier, Ronald C.; Griesser, Hans J.

doi:10.1002/(sici)1096-9918(200001)29:1<46::aid-sia692>3.0.co;2-6

Cited by 106 publications

(73 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…XPS detected some oxygen in the as-deposited plasma polymers, although at a low concentration (O/C = 0.065), probably due to reactions with atmospheric oxygen and water vapour. Different authors have shown that for plasma-deposited films, oxygen is incorporated in the XPS probe depth within very short times upon contact with air [38,39,40,41]. In this work, the detected oxygen may analogously be assigned to reaction between long-lived radicals trapped in the fluorocarbon coating and in-diffusing atmospheric O 2 .…”

Section: Resultsmentioning

confidence: 65%

“…XPS analyses were performed at two different angles in order to have a better idea of the ageing process induced on the fluorocarbon film at different depths (Figure 2). Indeed, due to the electron attenuation length λ of photoelectrons for C (1s), O (1s) and F (1s), the depth from which 95% of the detected XPS signals originated were estimated to range between ~4.5–6.0 nm for normal emission (at 90°) and ~1.0–1.5 nm for grazing emission (at 15°) [38,39]. …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Toward High-Performance Coatings for Biomedical Devices: Study on Plasma-Deposited Fluorocarbon Films and Ageing in PBS

2010

View full text Add to dashboard Cite

High performance coatings tailored to medical devices represent a recognised approach to modulate surface properties. Plasma-deposited fluorocarbon films have been proposed as a potential stent coating. Previous studies have shown promising adhesion properties: the 35 nm-thick film sustained plastic deformation up to 25% such as induced during the clinical implantation. In this study, the compositional and morphological changes of plasma-deposited fluorocarbon films were examined during ageing in a pseudo-physiological medium, a phosphate buffer solution (PBS), by angle-resolved XPS, FT-IR data and AFM images. The evolution of the ageing process is discussed: defluorination and crosslinking yielded an oxidized protective top layer onto the films, which showed further degradation.

show abstract

Section: Resultsmentioning

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Toward High-Performance Coatings for Biomedical Devices: Study on Plasma-Deposited Fluorocarbon Films and Ageing in PBS

2010

View full text Add to dashboard Cite

show abstract

“…Plasma polymers fabricated using organo-silicon monomers have excellent thermal and chemical resistance and outstanding electrical, optical, and biomedical properties. The common organo-silicon precursors include silane, disilane (SiSi), disiloxane (SiOSi), disilazane (SiNHSi), and disilthiane (SiSSi) [37,47,48].…”

Section: Plasma Polymerizationmentioning

confidence: 99%

Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,424

652

View full text Add to dashboard Cite

Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering. This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposition, plasma spraying, and so on. The unique advantage of plasma modification is that the surface properties and biocompatibility can be enhanced selectively while the bulk attributes of the materials remain unchanged. Existing materials can, thus, be used and needs for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical devices. Recent work has spurred a number of very interesting applications in the biomedical field. This review article concentrates upon the current status of these techniques, new applications, and achievements pertaining to biomedical materials research. Examples described include hard tissue replacements, blood contacting prostheses, ophthalmic devices, and other products. #

show abstract

“…Previous studies demonstrated that surface-immobilized dextran reduces cell adhesion and spreading in vitro. [12][13][14][15][16] Further work developed methods for immobilizing bioactive peptides to low cell-adhesive dextran monolayer coatings. 17 The substrates were shown to promote biospecific cell adhesion for vascular implant applications.…”

Section: Introductionmentioning

confidence: 99%

In vitro assessment of bioactive coatings for neural implant applications

Massia

Holecko

Ehteshami

2003

J Biomedical Materials Res

View full text Add to dashboard Cite

Recent efforts in our laboratory have focused on developing methods for immobilizing bioactive peptides to low cell-adhesive dextran monolayer coatings and promoting biospecific cell adhesion for biomaterial implant applications. In the current study, this dextran-based bioactive coating technology was developed for silicon, polyimide, and gold, the base materials utilized to fabricate our prototype neural implants. Chemical composition of all modified surfaces was verified by X-ray photoelectron spectroscopy (XPS). We observed that surface-immobilized dextran supported very little cell adhesion in vitro (24-h incubation with serum-supplemented medium) on all base materials. Inactive nonadhesion-promoting Gly-Arg-Ala-Asp-Ser-Pro peptides immobilized on dextran-coated materials promoted adhesion and spreading at low levels not significantly different from dextran-coated substrates. Arg-Gly-Asp (RGD) peptide-grafted surfaces were observed to promote substantial fibroblast and glial cell adhesion with minimal PC12 (neuronal cell) adhesion. In contrast, dextran-coated materials with surface-grafted laminin-based, neurite-promoting Ile-Lys-Val-Ala-Val (IKVAV) peptide promoted substantial neuron cell adhesion and minimal fibroblast and glial cell adhesion. It was concluded that neuron-selective substrates are feasible using dextran-based surface chemistry strategies. The chemical surface modifications could be utilized to establish a stable neural tissue-implant interface for longterm performance of neural prosthetic devices.

show abstract

Biomedical coatings by the covalent immobilization of polysaccharides onto gas-plasma-activated polymer surfaces

Cited by 106 publications

References 31 publications

Toward High-Performance Coatings for Biomedical Devices: Study on Plasma-Deposited Fluorocarbon Films and Ageing in PBS

Toward High-Performance Coatings for Biomedical Devices: Study on Plasma-Deposited Fluorocarbon Films and Ageing in PBS

Plasma-surface modification of biomaterials

In vitro assessment of bioactive coatings for neural implant applications

Contact Info

Product

Resources

About