Biometrics from the carbon isotope ratio analysis of amino acids in human hair

Jackson, Glen P.; An, Yan; Konstantynova, Kateryna I.; Rashaid, Ayat Hussein B.

doi:10.1016/j.scijus.2014.07.002

Cited by 23 publications

(25 citation statements)

References 44 publications

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“…Peninsula b -19.7 ±0.8 (116) (2,3); [4,32,36] Southeast Asia c -19.9 ±0.8 (36) (1-3); [4] China -20.1 ±1.3 (297) (3,5); [4,24,37,42,43] Central Asia incl. Mongolia d -20.3 ±0.7 (>29) (2,3); [34,42] Iran, Pakistan -20.4 ±0.4 (30) (3); [4,42] India incl.…”

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confidence: 99%

“…Northern Ireland 9.3 ±0.6 (≥128) (3,5); [4,9,11,17,20,36] Netherlands 9.4 ±0.5 (≥18) (3); [4,17,36,37] Belgium, Luxembourg 9.4 ±0.9 (≥19) + (2); [4,17,26,36] Portugal, Spain 9.4 ±0.6 (49) (1,3); [4,17] Norway 9.4 ±0.8 (≥13) (2,3); [4,36] Finland, Sweden 9.5 ±0.5 (16) (1-3); [4,17] Denmark 9.7 ±0.6 (57) + [4,14,17] Russia, Ukraine 9.9 ±0.9 (≥58) (2,3); [4,36] America Canada* 8.4 ±0.5 (16) [4,9] Costa Rica, Panama* 8.8 ±0.4 (19) (3); [4] Argentina, Chile, Uruguay 8.8 ±0.7 (10) (1-3); [4,9] USA 8. [4,32,36] Southeast Asia c 9.1 ±0.8 (36) (1-3); [4] Japan, Korea 9.5 ±0.7 (161) (1); [4,25,37,38] Central Asia incl. Mongolia d 9.9 ±1.0 (>29) (1-3); [34,42] Africa Western Africa h 9.4 ±0.8 (13) (1,3); [4] Eastern Africa f 9.4 ±1.1…”

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confidence: 99%

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Global spatial distributions of nitrogen and carbon stable isotope ratios of modern human hair

Hülsemann

Lehn

Schneiders

et al. 2015

Rapid Commun. Mass Spectrom.

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There are still a large proportion of countries, especially in Africa, where there are no available data for human carbon and nitrogen isotope ratios. Although the interpretation of modern human carbon isotope ratios at the global scale is quite possible, and correlates with the latitude, the potential influences of extrinsic and/or intrinsic factors on human nitrogen isotope ratios have to be taken into consideration.

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confidence: 99%

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confidence: 99%

Global spatial distributions of nitrogen and carbon stable isotope ratios of modern human hair

Hülsemann

Lehn

Schneiders

et al. 2015

Rapid Commun. Mass Spectrom.

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“…Regarding biometrics, carbon isotope ratio analysis of 15 amino acids in human hair can be used in a multivariate manner to classify donors into broad classes based on age group and body mass index. An example of the HPLC separation of amino acids from a hair hydrolysate and subsequent canonical discriminant analysis using amino acid isotope ratios as variables is provided in Figure 7 (147).…”

Section: Stable Isotope Analysismentioning

confidence: 99%

Forensic Mass Spectrometry

Hoffmann¹,

Jackson

2015

Annual Rev. Anal. Chem.

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Developments in forensic mass spectrometry tend to follow, rather than lead, the developments in other disciplines. Examples of techniques having forensic potential born independently of forensic applications include ambient ionization, imaging mass spectrometry, isotope ratio mass spectrometry, portable mass spectrometers, and hyphenated chromatography-mass spectrometry instruments, to name a few. Forensic science has the potential to benefit enormously from developments that are funded by other means, if only the infrastructure and personnel existed to adopt, validate, and implement the new technologies into casework. Perhaps one unique area in which forensic science is at the cutting edge is in the area of chemometrics and the determination of likelihood ratios for the evaluation of the weight of evidence. Such statistical techniques have been developed most extensively for ignitable-liquid residue analyses and isotope ratio analysis. This review attempts to capture the trends, motivating forces, and likely impact of developing areas of forensic mass spectrometry, with the caveat that none of this research is likely to have any real impact in the forensic community unless: (a) The instruments developed are turned into robust black boxes with red and green lights for positives and negatives, respectively, or (b) there are PhD graduates in the workforce who can help adopt these sophisticated techniques.

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“…11 Amino acids are the building blocks of keratin of hair, which is composed of 21 known amino acids. 11,14 Because the hair follicle uses circulating blood as the source of amino acids, hair growth can be influenced by the concentrations or isotope ratios of amino acids in blood. 12,14 There are relatively few studies associating diabetes and the amino acid composition of human scalp hair.…”

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confidence: 99%

“…11,14 Because the hair follicle uses circulating blood as the source of amino acids, hair growth can be influenced by the concentrations or isotope ratios of amino acids in blood. 12,14 There are relatively few studies associating diabetes and the amino acid composition of human scalp hair. For example, Oimomi et al found fructose-lysine (which is formed by binding glucose to lysine) is significantly higher in the hair of diabetic patients than in control subjects.…”

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confidence: 99%

Profiling Amino Acids of Jordanian Scalp Hair as a Tool for Diabetes Mellitus Diagnosis: A Pilot Study

2015

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Hair analysis is an area of increasing interest in the fields of medical and forensic sciences. Human scalp hair has attractive features in clinical studies because hair can be sampled easily and noninvasively from human subjects, and unlike blood and urine samples, it contains a chronological record of medication use. Keratin protein is the major component of scalp hair shaft material and it is composed of 21 amino acids. The method used herein for the amino acid determination in hair included keratin protein acid hydrolysis using 6 M hydrochloric acid (HCl), followed by amino acids derivatization using N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), and the determination of derivatized amino acids by gas chromatography/mass spectrometry (GC/MS). Amino acid profiles of scalp hair of 27 Jordanian subjects (15 diabetes mellitus (DM) type 2 patients and 12 control subjects) were analyzed. A fuzzy rule-building expert system (FuRES) classified the amino acid profiles into diabetic and control groups based on multivariate analyses of the abundance of 14 amino acids. The sensitivity and specificity were 100% for diabetes detection using leave-one-individual-out cross-validation. The areas under the receiver operative characteristics (ROC) curves were 1.0, which represents a highly sensitive and specific diabetes test. The nonessential amino acids Gly and Glu, and the essential amino acid Ile were more abundant in the scalp hair of diabetic patients compared to the hair of control subjects. The associations between the abundance of amino acids of human hair and health status may have clinical applications in providing diagnostic indicator or predicting other chronic or acute diseases.

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Biometrics from the carbon isotope ratio analysis of amino acids in human hair

Cited by 23 publications

References 44 publications

Global spatial distributions of nitrogen and carbon stable isotope ratios of modern human hair

Global spatial distributions of nitrogen and carbon stable isotope ratios of modern human hair

Forensic Mass Spectrometry

Profiling Amino Acids of Jordanian Scalp Hair as a Tool for Diabetes Mellitus Diagnosis: A Pilot Study

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