Biomimetic composite microspheres of collagen/chitosan/nano-hydroxyapatite: In-situ synthesis and characterization

Teng, Sheng; Liang, Mian-Hui; Wang, Peng; Luo, Yong

doi:10.1016/j.msec.2015.09.021

Cited by 29 publications

(21 citation statements)

References 14 publications

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“…[14,15]. Chitosan is one of the commonly used natural biopolymers with good sphere-forming capability, chemical stability, biocompatibility, and biodegradability [16,17]. However, when used as a drug carrier for bone tissue engineering, the poor mechanical strength and bioactivity of the chitosan microspheres have greatly limited their clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Niu

Teng

Zhou

et al. 2019

Journal of Nanomaterials

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Chitosan-silica (CS-SiO2) hybrid microspheres were prepared through the combined process of sol-gel and emulsification-crosslinking. Their composition, morphology, in vitro bioactivity, and drug release behavior were investigated. The results showed that, when 20 wt% SiO2 was incorporated, the as-prepared CS-SiO2 hybrid microspheres exhibited a regular spherical shape, a high dispersity, and a uniform microstructure. Their average particle diameter was determined to be about 24.0 μm. The in situ deposited inorganic phase of the hybrid microspheres was identified as amorphous SiO2, and its actual content was determined by the TG analysis. As compared with the pure chitosan microspheres, the CS-SiO2 hybrid microspheres displayed a greatly improved in vitro bioactivity. Vancomycin hydrochloride (VH) was selected as a model drug. It was demonstrated that the CS-SiO2 hybrid microspheres presented a good capacity for both loading and sustained release of VH. Moreover, the increase of the SiO2 content efficiently slowed down the drug release rate of the CS-SiO2 hybrid microspheres.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Niu

Teng

Zhou

et al. 2019

Journal of Nanomaterials

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“…(d)] was prepared by SPS process using an aqueous dispersion of FHA nanoparticles as feedstock. The composition and particle size of feedstock influences the phase composition, crystal structure, and crystallite size of the sprayed coating . Figure (a) presents the particle size and morphology of the as‐synthesized FHA nanoparticles by FE‐SEM measurement.…”

Section: Resultsmentioning

confidence: 99%

“…The composition and particle size of feedstock influences the phase composition, crystal structure, and crystallite size of the sprayed coating. 20 Figure 2(a) presents the particle size and morphology of the assynthesized FHA nanoparticles by FE-SEM measurement. The sample was prepared by putting several drops of FHA aqueous dispersion on the surface of a clean stainless steel sheet and the sheet was slowly dried up in air.…”

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confidence: 99%

Deposition of Nanostructured Fluorine‐Doped Hydroxyapatite Coating from Aqueous Dispersion by Suspension Plasma Spray

et al. 2016

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In this study, we prepared an aqueous dispersion of fluorine‐doped hydroxyapatite (FHA) nanoparticles by a wet chemical method. For the first time, the as‐prepared aqueous dispersion of FHA nanoparticles was directly used as suspension for depositing nanostructured FHA coating on stainless steel substrate by suspension plasma spray (SPS) method. Field‐emission scanning electron microscopy images confirm that the coating was nanostructured. X‐ray Diffraction pattern, Fourier‐transform infrared spectroscopy, and Raman spectra show that the as‐sprayed coating was FHA phases. The experimental result confirmed that OH− and F− ions have been well kept in FHA crystal lattice and structural integrity has been maintained during SPS process by using an aqueous dispersion of FHA nanoparticles. The potentiodynamic polarization and electrochemical impedance spectroscopy results prove that the nanostructured FHA coating can greatly enhance the anticorrosion performance of stainless steel in phosphate‐buffered saline solution.

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“…Both sponges and microspheres can be obtained based on blends of collagen and chitosan. The collagen/chitosan/hydroxyapatite composite microspheres with a good spherical form and a high dispersity were successfully obtained using an in situ synthesis method . The morphology of the composite microspheres was dependent on the hydroxyapatite content.…”

Section: Collagen/chitosan Compositesmentioning

confidence: 99%

Biopolymeric nanocomposites for potential biomedical applications

Sionkowska

2016

Polymer International

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This review reports recent advances in the field of biopolymeric composites and nanocomposites for potential biomedical applications. These materials have attracted both academic and, for several composites, industrial attention because they exhibit properties required in the biomedical field. Herein, the structure, preparation and properties of biopolymeric composite blends are discussed in general, and detailed examples are also drawn from the scientific literature and practical work. In this review the most common natural polymers collagen, chitosan and their composites and nanocomposites with inorganic particles are discussed.

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Biomimetic composite microspheres of collagen/chitosan/nano-hydroxyapatite: In-situ synthesis and characterization

Cited by 29 publications

References 14 publications

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Deposition of Nanostructured Fluorine‐Doped Hydroxyapatite Coating from Aqueous Dispersion by Suspension Plasma Spray

Biopolymeric nanocomposites for potential biomedical applications

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