Biomimetic glycopolymers tethered gold nanoparticles: Preparation, self-assembly and lectin recognition properties

Tailor-made glycopolymersviareversible deactivation radical polymerization: design, properties and applications

“…Besides, modification of AuNPs with glycopolymers further increases their colloidal stability and biocompatibility. 3,120,155,156 Glycopolymers prepared via RAFT polymerization are extensively used for the surface modification of AuNPs through Au–S bond formation (“grafting to” method) after reducing the chain ends. 3,120,156–158 Apart from the “grafting to” method, several authors reported the synthesis of glycopolymer–AuNPs using catechol chemistry without adding any reducing agent.…”

Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges

“…Functional gold surfaces to be used in SI-ATRP can be prepared from compounds having two functional groups: (i) thiol, which will be used to anchor the molecule to the gold surface and (ii) hydroxyl, that will allow esterification with the selected ATRP initiator precursor. If the ATRP initiator already possess a thiol functionality, it can be directly attached to the gold surface, thus avoiding the esterification step [ 24 , 25 ]. Glass and silicon substrates can be prepared by the esterification with the acyl bromide or chloride ATRP initiator derivatives or by silanization with ATRP initiators containing a silane reactive group [ 26 , 27 ].…”

“…N-methyl-d-glucamine and different glucose-and glucosamine-based acrylamide or (meth)acrylate monomers [30,33,43,[45][46][47][48][49][50][51], (Figure 4), either in their linear or ring form, have been synthesized and used for the preparation of well-defined polymer brushes by RDRP methods. The resultant materials have been extensively studied mainly for the specific binding and recognition by lectins [22,24,25,38,39,41,48,49,[51][52][53][54][55][56][57][58]. Very hydrophilic poly(2′-acrylamidoethyl-α-ᴅ-mannopyranoside) (PAAEM), poly(2′acrylamidoethyl-β-ᴅ-galactopyranoside) (PAAEGal) and poly(2′-acrylamidoethyl-β-ᴅglucopyranoside) (PAAEGlc) brushes, prepared by SI-ATRP from silicon substrates in water, exhibited a 149-, 172-, and 500-fold reduction of the non-specific adsorption of bovine serum albumin (BSA), respectively, as well as a 52-, 115-, and 135-fold fibrinogen (Fb) adsorption, respectively, in comparison to uncoated silicone surface [38].…”

“…On this matter, copolymer brushes containing both LBA and NIPAAm exhibited specific adsorption of RCA120 (KA of 1.86 × 10 5 M −1 for PLAMA brushes) [53] and adhesion of HepG2 cells at 37 °C [27]. Because of the thermo- Lactobionic acid (LBA) is a disaccharide composed of galactose and gluconic acid, which has been widely polymerized, in the form of vinyl monomer, to give materials for biomedical applications, mainly because of its ability to target HepG2 cells [24,103]. On this matter, copolymer brushes containing both LBA and NIPAAm exhibited specific adsorption of RCA 120 (K A of 1.86 × 10 5 M −1 for PLAMA brushes) [53] and adhesion of HepG2 cells at 37 • C [27].…”

Stereoisomerism effect on sugar–lectin binding of self-assembled glyco-nanoparticles of linear and brush copolymers

“…Considering the fact that many of the currently known CRDs only bind to the terminal oligosaccharides of glycans, glycopolymers with repeating pendent units show their great advantage in mimicking these terminal oligosaccharides [9][10][11][12], which is important to further exploration on both of the known and unknown carbohydrate-protein interactions. Meanwhile, the artificial glycopolymers and glyco-nanoparticles have show enhancement multivalent binding behavior of carbohydrate and lectins [13][14][15][16][17][18][19].…”