Biomimetic hollow mesoporous hydroxyapatite microsphere with controlled morphology, entrapment efficiency and degradability for cancer therapy

Qiao, Wei; Lan, Xinmiao; Tsoi, James Kit‐Hon; Chen, Zhuofan; Su, Yu‐xiong; Yeung, Kelvin Wai Kwok; Matinlinna, Jukka Pekka

doi:10.1039/c7ra09204k

Cited by 29 publications

(19 citation statements)

References 48 publications

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“…Recently, extensive studies have been concentrating on enhancing the drug delivery and release characteristics of CHA microsphere-based systems through granularity control. Many methods have been reported to synthesize flowerlike CHA microspheres, mostly including the hard template casting route [ 8 – 11 ] and soft template self-assembly route [ 12 , 13 ]. As to the former method, multi-step and complicated processes need to be carried out and thus one template is usually not enough to adjust the pore size.…”

Section: Introductionmentioning

confidence: 99%

Investigation of EDTA concentration on the size of carbonated flowerlike hydroxyapatite microspheres

Yao

Qi²,

Liang³

et al. 2021

R. Soc. open sci.

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Ethylenediamine tetraacetic acid (EDTA) is considered an effective crystal growth modifier for template-assisted hydrothermal synthesis of hydroxyapatite (HA) materials. In this work, flowerlike-carbonated HA (CHA) microspheres were synthesized using EDTA via a one-step hydrothermal route. The phase, functional groups, morphology and particle size distribution of the products were examined by X-ray diffraction, Fourier transform infrared spectrometer, field emission scanning electron microscopy as well as laser diffraction particle size analysis. Results show that the morphology of the products can be well controlled by adjusting the EDTA concentration. With an increase of the EDTA concentration, the particle size of flowerlike microspheres decreased from tens of microns down to a few microns. The underlying mechanism for the morphological transition of CHA microspheres with different concentrations of EDTA under hydrothermal conditions is proposed. This work provides a simple way to controllably fabricate CHA microspheres with various sizes using the same synthesis system for biomedical applications, such as cell carriers and drug delivery.

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Section: Introductionmentioning

confidence: 99%

Investigation of EDTA concentration on the size of carbonated flowerlike hydroxyapatite microspheres

Yao

Qi²,

Liang³

et al. 2021

R. Soc. open sci.

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“…[ 1–4 ] Recently, HAP nanoparticle has attracted more attention for NDDSs, owing to its biocompatible and noninflammatory properties. [ 3,5–9 ] Moreover, pH‐sensitive HAP nanoparticle can be degraded into calcium and phosphorous elements to ensure the effective release of the doped cargos under the slightly acidic conditions. [ 5,7,10 ] HAP as nanocarriers also have achieved targeted drugs delivery to promote the treatment efficiency and reduce side effects to the normal tissue and organs by the surface functionalization.…”

Section: Introductionmentioning

confidence: 99%

“…[ 3,5–9 ] Moreover, pH‐sensitive HAP nanoparticle can be degraded into calcium and phosphorous elements to ensure the effective release of the doped cargos under the slightly acidic conditions. [ 5,7,10 ] HAP as nanocarriers also have achieved targeted drugs delivery to promote the treatment efficiency and reduce side effects to the normal tissue and organs by the surface functionalization. [ 2,5,10–12 ] Our group succeeded in synthesizing biodegradable drug‐loaded hydroxyapatite nanoparticles modified with folic acid for targeted drug release [ 10 ] and ratiometric real‐time monitoring of nanodrug based on hydroxyapatite for tumor targeted chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Light‐triggered dePEGylation with decreasing the diameter of hydroxyapatite nanocarriers for enhanced cellular uptake and tumor penetration

Zhang

et al. 2021

Nano Select

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PEGylation of nano-drug delivery systems (NDDSs) has been investigated to overcome the side effect of conventional chemotherapy including improving pharmacokinetics by prolonging drug circulation, reducing immune clearance and premature drug leakage. Although, PEGylation of NDDSs can also disturb the tumor penetration and cellular uptake with the diameter enhancement. Therefore, in this work, we constitute a light-triggered dePEGylation strategy, which results in the decrease of diameter of the pH-responsive hydroxyapatite drug nanocarriers (DOX@HAP-PEG) for enhanced cellular uptake and tumor penetration. Under light irradiation (650 nm), PEG chains can be availably separated from the nanocarrier by cleaving the Cy linker. Moreover, the cellular

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“…Amongst them, nanoparticle-assembled hollow microspheres provide advantages to adsorbents because they have higher specific areas for adsorption in comparison with simple microspheres and are more convenient to handle in comparison with nanoparticles [5, 7, 8]. Hollow HA microspheres can be synthesized using various methods including spray drying [9], solvothermal/hydrothermal synthesis [6, 10, 11], conversion CaCO 3 microspheres [12, 13, 14] and Li 2 O-CaO-B 2 O 3 [15,16], and assembly approaches with organic/inorganic materials. In assembly approaches, surfactants [17, 18], amino acids [19], polymers [20, 21, 22], and yeast cells [23] have been used to form hollow microspherical structures.…”

Section: Introductionmentioning

confidence: 99%

Protein adsorption characteristics of nanoparticle-assembled hollow microspheres of hydroxyapatite and their composites with PLLA microporous membranes

Tanaka

Takai

Nagase

et al. 2019

Heliyon

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Nanoparticle-assembled hydroxyapatite (HA) hollow microspheres have a high surface area and are convenient to handle, owing to their characteristic structure. In this study we characterized the protein adsorption of HA hollow microspheres prepared from CaCl 2 and K 2 HPO 4 by a water-in-oil-in-water (W/O/W) emulsion method assisted by two surfactants: Span 80 and Tween 20. The HA hollow microspheres adsorbed bovine serum albumin, bovine γ-globulin, equine skeletal muscle myoglobin, and chicken egg white lysozyme in 10 mM sodium phosphate buffer (pH 6.8) in a Langmuir-type adsorption and desorbed the proteins in 800 mM sodium phosphate buffer (pH 6.8). The maximum adsorbed amounts of the HA hollow microspheres were 7.5–9.0 times higher than those of the microrods with a similar size range. The composite membranes of the HA microspheres and the poly( l -lactic acid) (PLLA) microporous membranes exhibited a high adsorption capacity for γ-globulin.

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Biomimetic hollow mesoporous hydroxyapatite microsphere with controlled morphology, entrapment efficiency and degradability for cancer therapy

Abstract: Hollow mesoporous carbonated hydroxyapatite microspheres produced via sodium dodecyl sulfate assisted precipitation can target cancer cells through acidic dependent release of loaded CDDP.

Cited by 29 publications

References 48 publications

Investigation of EDTA concentration on the size of carbonated flowerlike hydroxyapatite microspheres

Investigation of EDTA concentration on the size of carbonated flowerlike hydroxyapatite microspheres

Light‐triggered dePEGylation with decreasing the diameter of hydroxyapatite nanocarriers for enhanced cellular uptake and tumor penetration

Protein adsorption characteristics of nanoparticle-assembled hollow microspheres of hydroxyapatite and their composites with PLLA microporous membranes

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